Cited by Investigate the Relationship between Thyroid Function and Cognitive Dysfunction in Patients with Type 2 Diabetes Mellitus

Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications DOI

Yan Sun,

Shouyang Gao,

Cong Ye

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 24, 2023

Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis PCOS complex has not yet been fully clarified. Gut microbiota associated with lipid, glucose, steroid hormone metabolish. A large body studies demonstrated gut could regulate synthesis secretion insulin, affect androgen metabolism follicle development, providing us a novel idea for unravelling PCOS. relationship between particularly important. This study reviewed recent research advances roles occurrence development It expected provide new direction treatment based on microbiota.

Language: Английский

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The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction DOI

Zi-han Li, Yayi Jiang,

Caiyi Long

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(S1), P. 59 - 73

Published: Jan. 4, 2023

Abstract Background Diabetic cognitive dysfunction (DCD) is one of the most insidious complications type 2 diabetes mellitus, which can seriously affect ability to self‐monitoring blood glucose and quality life in elderly. Previous pathological studies have focused on neuronal dysfunction, characterized by extracellular beta‐amyloid deposition intracellular tau hyperphosphorylation. In recent years, astrocytes been recognized as a potential therapeutic target for important participants central control metabolism. The disorder gut microbiota their metabolites linked series metabolic diseases such mellitus. imbalance intestinal flora has effect promoting occurrence deterioration several diabetes‐related complications. Gut microbes drive astrocyte activation. Aims We reviewed progress DCD related “gut microbiota‐astrocyte” axis terms peripheral inflammation, blood–brain barrier (BBB) systemic brain energy metabolism disorders deepen research explore targets. Conclusion “Gut axis, unique bidirectional crosstalk brain‐gut mediates intermediate process neurocognitive secondary

Language: Английский

Citations

The gut microbiota–brain axis in neurological disorders DOI

Mingming You,

Nan Chen, Yuanyuan Yang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Language: Английский

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Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis DOI

Yi Pan, Tong Bu, Xia Deng

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 84(1), P. 1 - 15

Published: Jan. 16, 2024

Language: Английский

Citations

Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF‐кB pathway through microbiota‐gut‐brain axis DOI

Zhi‐Tong Zhang,

Si‐Min Deng,

Chong Chen

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(8), P. 3522 - 3542

Published: April 10, 2023

Diabetic cognitive impairment (DCI) is a serious neurodegenerative disorder caused by diabetes, with chronic inflammation being crucial factor in its pathogenesis. Pterostilbene well-known natural stilbene derivative that has excellent anti-inflammatory activity, suggesting potential medicinal advantages for treating DCI. Therefore, this study to explore the beneficial effects of pterostilbene improving dysfunction DCI mice. A diabetic model was induced high-fat diet plus streptozotocin (40 mg·kg-1 ) consecutive 5 days. After animals were confirmed be state, they treated (20 or 60 , i.g.) 10 weeks. Pharmacological evaluation showed could ameliorate dysfunction, regulate glycolipid metabolism disorders, improve neuronal damage, and reduce accumulation β-amyloid alleviated neuroinflammation suppressing oxidative stress carbonyl astrocyte microglia activation, dopaminergic loss. Further investigations reduced level lipopolysaccharide, modulated colon brain TLR4/NF-κB signaling pathways, decreased release inflammatory factors, which turn inhibited intestinal neuroinflammation. Furthermore, also homeostasis microbiota, increase levels short-chain fatty acids their receptors, suppress loss tight junction proteins. In addition, results plasma non-targeted metabolomics revealed modulate differential metabolites metabolic pathways associated inflammation, thereby systemic Collectively, our found first time alleviate inhibiting pathway through microbiota-gut-brain axis, may one mechanisms neuroprotective effects.

Language: Английский

Citations

The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis DOI

Kangqin Yang,

Yang Liu, Min Zhang

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(2), P. 158 - 158

Published: Feb. 4, 2024

Astrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response pathological stimuli. This process results the loss of typical astrocyte functions acquisition neurotoxic or neuroprotective roles. A growing body research indicates that these astrocytes play a pivotal role pathogenesis amyotrophic lateral sclerosis (ALS), involving calcium homeostasis imbalance, mitochondrial dysfunction, abnormal lipid lactate metabolism, glutamate excitotoxicity, etc. review summarizes characteristics astrocytes, ALS, recent advancements astrocyte-targeting strategies.

Language: Английский

Citations

Fecal microbiota transplantation derived from mild cognitive impairment individuals impairs cerebral glucose uptake and cognitive function in wild-type mice: Bacteroidetes and TXNIP-GLUT signaling pathway DOI

Tao Wang, Ling Hao, Kexin Yang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 12, 2024

Gut microbiome dysbiosis has been widely implicated in cognitive impairment, but the identity of specific bacterial taxa and mechanisms are not fully elucidated. Brain glucose hypometabolism coincides with decline. This study explored link among cognition, gut microbiota uptake based on fecal transplantation from mild impairment individuals (MCI-FMT) investigated whether similar were involved 27-hydroxycholesterol (27-OHC)-induced Our results showed that MCI-FMT mice exhibited learning memory decline morphological lesions brain colon tissues. There reduced

Language: Английский

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Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy DOI

Xue Wen, Luming Qi, Kui Zhao

et al.

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the microbiome a new potential therapeutic focus. This commentary examines recent publication World Journal Diabetes . article explores association between T2DM microbiota, focus on pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted strategies evaluates challenges future directions such approaches. editorial summarizes key points their discussion role elaborates influence specific microbial species disease through host–microbiota metabolic axis. provides insights for research gut-microbiota-based interventions T2DM.

Language: Английский

Citations

Modulation of Glial Cell Functions by the Gut–Brain Axis: A Role in Neurodegenerative Disorders and Pain Transmission DOI

Giulia Magni, Benedetta Riboldi, Stefania Ceruti

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1612 - 1612

Published: June 13, 2023

Studies on host microbiota and their interactions with the central nervous system (CNS) have grown considerably in last decade. Indeed, it has been widely demonstrated that dysregulations of bidirectional gut–brain crosstalk are involved development several pathological conditions, including chronic pain. In addition, activation peripheral glial cells is also implicated pathogenesis progression pain other neurodegenerative disorders. Recent preclinical findings suggest gut plays a pivotal role regulating maturation, morphology function, possibly through action different microbial metabolites, most studied short-chain fatty acids (SCFAs). Moreover, altered composition reported CNS disorders characterized by cell activation. this review, we discuss recent studies showing effects its depletion modulating function (microglia astrocytes), hypothesize possible for glia–microbiota maintenance

Language: Английский

Citations

Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic Encephalopathy DOI

Xin Cheng, Yejun Tan, Hongli Li

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 8253 - 8278

Published: March 14, 2024

Language: Английский

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