Post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis DOI Creative Commons

Yuan Niu,

Zhang-Hong Lv,

Chunrong Sun

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 16, 2023

Background Post-acute coronavirus disease 2019 (COVID-19) symptoms occurred in most of the COVID-19 survivors. However, few studies have examined issue whether hospitalization results different post-acute symptom risks. This study aimed to compare potential long-term effects hospitalized and non-hospitalized Methods is designed as a systematic review meta-analysis observational studies. A search six databases was performed for identifying articles published from inception until April 20th, 2022, which compared risk survivors using predesigned strategy included terms SARS-CoV-2 (eg, COVID, , 2019-nCoV ), Syndrome post-COVID, post COVID conditions, chronic symptom, long long-haul sequelae, convalescence persistent ( hospitalized, hospital home-isolated ). The present conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020 statement R software 4.1.3 create forest plots. Q statistics I 2 index were used evaluate heterogeneity this meta-analysis. Results Six Spain, Austria, Switzerland, Canada, USA involving 419 742 included. number ranged 63 431, follow-up data collected through visits four another two an electronic questionnaire, visit telephone, respectively. Significant increase risks dyspnea (OR = 3.18, 95% CI 1.90–5.32), anxiety 3.09, 1.47–6.47), myalgia 2.33, 1.02–5.33), hair loss 2.76, 1.07–7.12) found with outpatients. Conversely, persisting ageusia significantly reduced than patients. Conclusion findings suggested that special attention patient-centered rehabilitation service based on needs survey should be provided who experienced high risk.

Language: Английский

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis DOI Open Access
Felicia Ceban, Susan Ling, Leanna M.W. Lui

et al.

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 101, P. 93 - 135

Published: Dec. 29, 2021

Language: Английский

Citations

1246
Characterising long COVID: a living systematic review DOI Creative Commons
Melina Michelen, Lakshmi Manoharan, Natalie Elkheir

et al.

BMJ Global Health, Journal Year: 2021, Volume and Issue: 6(9), P. e005427 - e005427

Published: Sept. 1, 2021

While it is now apparent clinical sequelae (long COVID) may persist after acute COVID-19, their nature, frequency and aetiology are poorly characterised. This study aims to regularly synthesise evidence on long COVID characteristics, help inform management, rehabilitation strategies interventional studies improve long-term outcomes.A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Research COVID-19 database, LitCovid Google Scholar were searched till 17 March 2021. Studies including at least 100 people with confirmed or clinically suspected 12 weeks more post onset included. Risk of bias was assessed using the tool produced by Hoy et al. Results analysed descriptive statistics meta-analyses estimate prevalence.A total 39 included: 32 cohort, 6 cross-sectional 1 case-control. Most showed high moderate risk bias. None set in low-income countries few included children. reported 10 951 (48% female) countries. previously hospitalised (78%, 8520/10 951). The longest mean follow-up time 221.7 (SD: 10.9) days onset. Over 60 physical psychological signs symptoms wide prevalence reported, most commonly weakness (41%; 95% CI 25% 59%), general malaise (33%; 15% 57%), fatigue (31%; 24% 39%), concentration impairment (26%; 21% 32%) breathlessness (25%; 18% 34%). 37% (95% 60%) patients reduced quality life; 26% (10/39) presented pulmonary function.Long a complex condition prolonged heterogeneous symptoms. nature precludes precise case definition evaluation. There an urgent need for prospective, robust, standardised, controlled into aetiology, factors biomarkers characterise different at-risk populations settings.CRD42020211131.

Language: Английский

Citations

786
Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021 DOI Open Access
Sarah Wulf Hanson, Cristiana Abbafati, Joachim G.J.V. Aerts

et al.

JAMA, Journal Year: 2022, Volume and Issue: 328(16), P. 1604 - 1604

Published: Oct. 10, 2022

Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).To estimate the proportion of males and females with COVID-19, younger or older than 20 years age, who had COVID in 2020 2021 their symptom duration.Bayesian meta-regression pooling 54 studies 2 medical record databases data for 1.2 million (from 22 countries) infection. Of studies, 44 were published 10 collaborating cohorts (conducted Austria, Faroe Islands, Germany, Iran, Italy, Netherlands, Russia, Sweden, Switzerland, US). The participant derived from (10 501 hospitalized 42 891 nonhospitalized individuals), cohort 526 1906), US electronic (250 928 846 046). Data collection spanned March January 2022.Symptomatic infection.Proportion at least 1 3 self-reported clusters (persistent fatigue bodily pain mood swings; cognitive problems; ongoing respiratory problems) months 2021, estimated separately aged by sex both sexes age.A total included (mean 4-66 years; males, 26%-88%). In modeled estimates, 6.2% (95% uncertainty interval [UI], 2.4%-13.3%) experienced including 3.2% UI, 0.6%-10.0%) swings, 3.7% 0.9%-9.6%) problems, 2.2% 0.3%-7.6%) problems adjusting health status before comprising an 51.0% 16.9%-92.4%), 60.4% 18.9%-89.1%), 35.4% 9.4%-75.1%), respectively, cases. more common women (10.6% [95% 4.3%-22.2%]) men (5.4% 2.2%-11.7%]). Both age be affected 2.8% 0.9%-7.0%) infections. mean cluster duration was 9.0 7.0-12.0 months) among 4.0 3.6-4.6 individuals. Among infection, 15.1% 10.3%-21.1%) continued 12 months.This study presents estimates

Language: Английский

Citations

654
Onset and frequency of depression in post-COVID-19 syndrome: A systematic review DOI Open Access

Olivier Renaud‐Charest,

Leanna M.W. Lui, Sherry Eskander

et al.

Journal of Psychiatric Research, Journal Year: 2021, Volume and Issue: 144, P. 129 - 137

Published: Sept. 30, 2021

Language: Английский

Citations

329
COVID-19 associated cognitive impairment: A systematic review DOI
José Wagner Leonel Tavares-Júnior, Ana Célia Caetano de Souza,

José W.P. Borges

et al.

Cortex, Journal Year: 2022, Volume and Issue: 152, P. 77 - 97

Published: April 18, 2022

Language: Английский

Citations

140
ESCMID rapid guidelines for assessment and management of long COVID DOI Creative Commons
Dana Yelin, Charalampos D. Moschopoulos, Ili Margalit

et al.

Clinical Microbiology and Infection, Journal Year: 2022, Volume and Issue: 28(7), P. 955 - 972

Published: Feb. 17, 2022

Language: Английский

Citations

113
Neurological outcomes 1 year after COVID‐19 diagnosis: A prospective longitudinal cohort study DOI Creative Commons
Verena Rass, Ronny Beer,

Alois Josef Schiefecker

et al.

European Journal of Neurology, Journal Year: 2022, Volume and Issue: 29(6), P. 1685 - 1696

Published: March 3, 2022

Neurological sequelae from coronavirus disease 2019 (COVID-19) may persist after recovery acute infection. Here, the aim was to describe natural history of neurological manifestations over 1 year COVID-19.A prospective, multicentre, longitudinal cohort study in COVID-19 survivors performed. At a 3-month and 1-year follow-up, patients were assessed for impairments by examination standardized test battery including assessment hyposmia (16-item Sniffin' Sticks test), cognitive deficits (Montreal Cognitive Assessment < 26) mental health (Hospital Anxiety Depression Scale Post-traumatic Stress Disorder Checklist 5).Eighty-one evaluated COVID-19, out which 76 (94%) completed follow-up. Patients 54 (47-64) years old 59% male. New persistent disorders found 15% (3 months) 12% (10/81; year). Symptoms at follow-up reported 48/81 (59%) patients, fatigue (38%), concentration difficulties (25%), forgetfulness sleep disturbances (22%), myalgia (17%), limb weakness headache (16%), impaired sensation (16%) (15%). revealed findings 52/81 (64%) without improvement time months, 61%, p = 0.230) objective (Sniffin' <13; 51%). apparent 18%, whereas signs depression, anxiety post-traumatic stress 6%, 29% 10% respectively These had not improved (all > 0.05).Our data indicate that significant patient number still suffer neuropsychiatric symptoms calling interdisciplinary management these patients.

Language: Английский

Citations

92
Characterization of autonomic symptom burden in long COVID: A global survey of 2,314 adults DOI Creative Commons
Nicholas Larsen, Lauren E. Stiles,

Ruba Shaik

et al.

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 19, 2022

Autonomic dysfunction is a known complication of post-acute sequelae SARS-CoV-2 (PASC)/long COVID, however prevalence and severity are unknown.To assess the frequency, severity, risk factors autonomic in PASC, to determine whether acute infection associated with dysfunction.Cross-sectional online survey adults PASC recruited through long COVID support groups between October 2020 August 2021.2,413 ages 18-64 years including patients who had confirmed positive test for COVID-19 (test-confirmed) participants were diagnosed based on clinical symptoms alone.The main outcome measure was Composite Symptom 31 (COMPASS-31) total score, used global dysfunction. Test-confirmed hospitalized vs. test-confirmed non-hospitalized compared if dysfunction.Sixty-six percent COMPASS-31 score >20, suggestive moderate severe scores did not differ [28.95 (15.62, 46.60) 26.4 (13.75, 42.10); p = 0.06].Evidence seen 66% our study, independent hospitalization status, suggesting that highly prevalent population illness.

Language: Английский

Citations

91
A systematic review on physical function, activities of daily living and health-related quality of life in COVID-19 survivors DOI Open Access
Katna de Oliveira Almeida, Iura Gonzalez Nogueira Alves, Rodrigo Santos de Queiroz

et al.

Chronic Illness, Journal Year: 2022, Volume and Issue: 19(2), P. 279 - 303

Published: April 11, 2022

To analyze the published studies that investigated physical function, activities of daily living and health-related quality life in COVID-19 survivors.Systematic review.We searched MEDLINE/PubMed, Scopus, SciELO, Cochrane Library for evaluated after from earliest date available to July 2021. Two independent reviewers screened selected studies. The Newcastle Ottawa Scale was used evaluate methodological quality.We included 35 this systematic review. Of included, 28 were cohort, 7 cross-sectional demonstrated survivors had reduced levels living, life. Furthermore, incomplete recovery performance observed 1 6 months post-infection.Physical disability reduction is a common condition post-COVID-19 impairments may persist up months. Researchers clinicians can use these findings understand potential disabilities rehabilitation needs people recovering COVID-19.

Language: Английский

Citations

89
Systematic Review of the Prevalence of Long COVID DOI Creative Commons
Mirembe Woodrow, Charles Carey, Nida Ziauddeen

et al.

Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 10(7)

Published: May 3, 2023

Abstract Background Long COVID occurs in those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whose symptoms persist or develop beyond the phase. We conducted a systematic review to determine prevalence of persistent symptoms, functional disability, pathological changes adults children at least 12 weeks postinfection. Methods searched key registers and databases from January 1, 2020 November 2, 2021, limited publications English studies 100 participants. Studies which all participants were critically ill excluded. was extracted as 1 symptom pathology, most common later. Heterogeneity quantified absolute terms proportion total variation explored across predefined subgroups (PROSPERO ID CRD42020218351). Results One hundred twenty 130 included. Length follow-up varied between months. Few had low risk bias. All complete subgroup analyses except I2 ≥90%, range 0%–93% (pooled estimate [PE], 42.1%; 95% prediction interval [PI], 6.8% 87.9%). using routine healthcare records tended report lower (PE, 13.6%; PI, 1.2% 68%) symptoms/pathology than self-report 43.9%; 8.2% 87.2%). However, systematically investigating pathology follow up highest estimates 3 51.7%; 12.3% 89.1%). hospitalized cases generally higher community-based studies. Conclusions The way is defined measured affects estimation. Given widespread nature SARS-CoV-2 infection globally, burden chronic illness likely be substantial even conservative estimates.

Language: Английский

Citations

81