DREADD activation of the lateral septum alters prosocial and antisocial behaviors, but not partner preferences in male prairie voles DOI Creative Commons
Lindsay L. Sailer, Ashley Park,

Abigail Galvez

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 27, 2022

Abstract Although much has been written on the topic of social behavior, many terms referring to different aspects behavior have become inappropriately conflated and specific mechanisms governing them remains unclear. It is therefore critical that we disentangle pro- anti-social elements associated with forms fully understand brain. The lateral septum (LS) mediates behaviors, emotional processes, stress responses necessary for individuals navigate day-to-day interactions. LS particularly important in general selective prosocial (monogamy) but its role how these two behavioral domains intersect Here, investigate effects chemogenetic-mediated activation male prairie voles when they are 1) sex-naïve generally affiliative 2) after pair-bonded display aggression. Amplifying neural activity augments same-sex approach behaviors. Despite partner preference formation remaining unaltered, males leads reduced aggression while increasing These results suggest alters within certain contexts, by behaviors reducing pair bonding-induced conspecifics, not altering bonding opposite-sex individuals.

Language: Английский

Reciprocal processes of sensory perception and social bonding: an integrated social‐sensory framework of social behavior DOI
Nora H. Prior, Ehren J. Bentz, Alexander G. Ophir

et al.

Genes Brain & Behavior, Journal Year: 2021, Volume and Issue: 21(3)

Published: Dec. 14, 2021

Abstract Organisms filter the complexity of natural stimuli through their individual sensory and perceptual systems. Such filtering is particularly important for social stimuli. A shared “social umwelt” allows individuals to respond appropriately expected diversity cues signals during interactions. In this way, behavioral neurobiological mechanisms sociality bonding cannot be disentangled from processing. While a degree embeddedness between processes clear, our dominant theoretical frameworks favor treating as distinct. An integrated social‐sensory framework has potential greatly expand understanding underlying variation in more broadly. Here we leverage what known about processing pair two common study systems with significant species differences umwelt (rodent chemosensation avian acoustic communication). We primarily highlight that (1) communication essential bond formation maintenance, (2) neural circuits perception, are integrated, (3) candidate neuromodulatory regulate also impact perception. Finally, propose approaches fully integrate processing, communication, across levels analysis: behavioral, neurobiological, genomic. This perspective raises key questions: how shaped by processing?, extent saliency interactions emerging relationships?

Language: Английский

Citations

25
Motherhood and DREADD manipulation of the nucleus accumbens weaken established pair bonds in female prairie voles DOI Creative Commons
Santiago A. Forero, Lindsay L. Sailer,

Aistė Girčytė

et al.

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 151, P. 105351 - 105351

Published: March 30, 2023

Language: Английский

Citations

9
Lateral septum DREADD activation alters male prairie vole prosocial and antisocial behaviors, not partner preferences DOI Creative Commons
Lindsay L. Sailer, Ashley Park,

Abigail Galvez

et al.

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: Nov. 26, 2022

Abstract Although much has been written on the topic of social behavior, many terms referring to different aspects behavior have become inappropriately conflated and specific mechanisms governing them remains unclear. It is therefore critical that we disentangle prosocial antisocial elements associated with forms fully understand brain. The lateral septum (LS) mediates behaviors, emotional processes, stress responses necessary for individuals navigate day-to-day interactions. LS particularly important in general selective (monogamy) but its role how these two behavioral domains intersect Here, investigate effects chemogenetic-mediated activation male prairie voles when they are 1) sex-naïve generally affiliative 2) after pair-bonded display aggression. Amplifying neural activity augments same-sex approach behaviors. Despite partner preference formation remaining unaltered, males leads reduced aggression while increasing These results suggest alters within certain contexts, by behaviors reducing pair bonding-induced conspecifics, not altering bonding opposite-sex individuals.

Language: Английский

Citations

14
Neuroendocrine Mechanisms Underlying Reproductive Decision Making Across Taxa DOI

Mary R. Elson,

Nora H. Prior, Alexander G. Ophir

et al.

Masterclass in neuroendocrinology, Journal Year: 2024, Volume and Issue: unknown, P. 157 - 191

Published: Jan. 1, 2024

Language: Английский

Citations

2
Social isolation: relationship with cardiovascular diseases DOI
Г. И. Лобов

Успехи физиологических наук, Journal Year: 2024, Volume and Issue: 55(1)

Published: March 15, 2024

Social and demographic changes in the recent decades have led to an increase prevalence of social isolation loneliness modern society. are common but underrated factors that determine health, especially cardiovascular health. In addition, results various studies shown negative impact leads dysfunction other systems. accompanied by development oxidative stress brain structures. This activates neurons prefrontal cortex limbic areas, which is prolonged increased production glucocorticoid hormones, eventually leading resistance glucocorticoids. At same time, sympathetic nervous system also activated, which, against backdrop glucocorticoids, causes a persistent blood pressure pro-inflammatory state. As result, lonely people experience peripheral vascular pressure. atherosclerotic arteries develop faster. Although molecular mechanisms responsible for risk socially isolated not well studied, these been proven contribute developing disease. Current measures fight potential reduce their on However, given limited use, effectiveness society as whole insufficient. order better understand more in-depth research effective interventions needed.

Language: Английский

Citations

2
The association between subjective cognitive decline and trajectories of objective cognitive decline: Do social relationships matter? DOI Creative Commons
Manacy Pai, Wentian Lu,

Miaoqi Chen

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2023, Volume and Issue: 111, P. 104992 - 104992

Published: March 8, 2023

We examine the association between subjective cognitive decline (SCD) and trajectories of objective (OCD); extent to which this is moderated by social relationships.Data come from waves 10 (2010) through 14 (2018) Health Retirement Study, a nationally representative panel survey individuals aged 50 above in United States. OCD measured using episodic memory, overall cognition. SCD assessed baseline measure self-rated memory. Social relationships are network size perceived positive negative support. Growth curve models estimate longitudinal link subsequent interactions relationship variables on OCD.SCD associated with OCD. A wider lower support linked slower None variables, however, moderate future OCD.Knowing that useful because at stage, deficits more manageable relative those stages Future work should consider additional dimensions relationships.

Language: Английский

Citations

6
Context-dependent activation of a social behavior brain network during learned vocal production DOI
Katherine L. Anderson,

Lionel Colón,

Violet Doolittle

et al.

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 228(7), P. 1785 - 1797

Published: Aug. 24, 2023

Language: Английский

Citations

5
Cupid’s quiver: Integrating sensory cues in rodent mating systems DOI Creative Commons
Nerissa E. G. Hoglen, Devanand S. Manoli

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 16

Published: July 25, 2022

In many animal species, males and females exploit different mating strategies, display sex-typical behaviors, use distinct systems to recognize ethologically relevant cues. Mate selection thus requires mutual recognition across diverse social interactions based on sensory signals. These sex differences in courtship behaviors correspond downstream neural substrates engaged respond rodents, tend rely heavily volatile olfactory pheromone cues, while appear be guided more by a combination of these chemosensory signals with acoustic cues the form ultrasonic vocalizations. The mechanisms which chemical are integrated control behavior understudied but known important maternal behaviors. Socially monogamous species constitute behaviorally group rodents. anatomic between outside nervous system less prominent than non-monogamous systems, both sexes engage symmetric attachments. Nevertheless, despite apparent similarities displayed females, circuitry supporting social, mating, attachment is increasingly thought differ sexes. Sex modalities most for mate particular interest present wealth questions yet answered. Here, we discuss how may drive differing roles specific eliciting displays or males.

Language: Английский

Citations

8
The parental umwelt: Effects of parenthood on sensory processing in rodents DOI Creative Commons
Kerianne M. Wilson, April M. Arquilla, Wendy Saltzman

et al.

Journal of Neuroendocrinology, Journal Year: 2023, Volume and Issue: 35(7)

Published: Jan. 24, 2023

Abstract An animal's umwelt, comprising its perception of the sensory environment, which is inherently subjective, can change across lifespan in accordance with major life events. In mammals, onset motherhood, particular, associated a neural and plasticity that alters mother's detection use information such as infant‐related stimuli. Although literature surrounding mammalian mothers well established, very few studies have addressed effects parenthood on fathers. this review, we summarize findings behavioural responses to stimuli from pups rodent mothers, focus olfactory, auditory, somatosensory systems, multisensory integration. We also review available Finally, discuss importance for effective parental care, hormonal modulation plasticity, an exploration temporal, ecological, life‐history considerations parenthood. The changes processing and/or care may both transient long‐lasting behaviour cognition fathers; such, several promising areas study, molecular/genetic, neurochemical, experiential underpinnings parenthood‐related determinants interspecific variation, remain potential avenues further exploration.

Language: Английский

Citations

4
Evidence for individual vocal recognition in a pair-bonding poison frog, Ranitomeya imitator DOI

Molly E. Podraza,

Jeanette B. Moss, Eva K. Fischer

et al.

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(3)

Published: Jan. 17, 2024

ABSTRACT Individually distinctive vocalizations are widespread in nature, although the ability of receivers to discriminate these signals has only been explored through limited taxonomic and social lenses. Here, we asked whether anuran advertisement calls, typically studied for their role territory defense mate attraction, facilitate recognition preferential association with partners a pair-bonding poison frog (Ranitomeya imitator). Combining no- two-stimulus choice playback experiments, evaluated behavioral responses females male acoustic stimuli. Virgin oriented approached speakers broadcasting calls independent caller identity, implying that generally attracted stimuli outside context pair bond. When pair-bonded were presented stranger, they showed significant preference mate. Moreover, varied breeding status: eggs faster approach than bonded but did not currently have eggs. Our study suggests potential individual vocal formation maintenance bonds raises new questions about how perceived monogamy biparental care.

Language: Английский

Citations

1