The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study DOI Creative Commons
Wei Fu, Junlong Zhao,

GuoBin Chen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 9, 2023

ABSTRACT Background The Triglyceride-glucose (TyG) index is an emerging marker for insulin resistance and metabolic syndrome. Helicobacter pylori, a bacterium associated with gastrointestinal diseases, may also influence risk profiles. This study aimed to investigate the relationship between TyG pylori infection among representative sample of adults. Methods A total 9965 participants from NHANES 1999-2000 cycle were involved March 1, 1999, December 2000.A cross-sectional analysis was conducted on 3797 participants. baseline characteristics according quartile evaluated.Multivariate binary logistic regression models constructed analyze independent effects infection. two-piecewise model used explore non-linear inflection point identified. Subgroup analyses performed assess trends effect sizes across different variables including age, sex, glucose levels, body mass (BMI), chronic kidney disease (CKD). Results Multivariate indicated linear infection, suggesting differential demonstrated significant interactions only few variables, all p-values interaction below 0.05. Conclusions suggests association infection.These findings have implications understanding influences guide targeted interventions at-risk populations.

Language: Английский

Research progress on Helicobacter pylori infection related neurological diseases DOI
Fan Wang,

Zhendong Yao,

Tao Jin

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102399 - 102399

Published: June 30, 2024

Language: Английский

Citations

9
The association between helicobacter pylori infection and Triglyceride-Glucose (TyG) index in US adults: A retrospective cross-sectional study DOI Creative Commons
Wei Fu, Junlong Zhao,

GuoBin Chen

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0295888 - e0295888

Published: Jan. 3, 2025

Background The Triglyceride-glucose (TyG) index is a marker for insulin resistance and metabolic syndrome, while Helicobacter pylori linked to gastrointestinal diseases may affect risks. This study examined the association between TyG H. infection in adults. Methods Data from 3797 participants NHANES 1999–2000 cycle were analyzed. relationship was assessed using multivariate logistic regression two-piecewise model explore non-linear effects. Subgroup analyses conducted based on age, sex, glucose levels, BMI, CKD. Results A linear found. revealed significant interactions with few variables. Conclusions indicates infection, suggesting influences potential targeted interventions at-risk groups.

Language: Английский

Citations

1
Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer DOI

Lingxiao Jin,

Yu-Peng Fang,

Chenmei Xia

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(24), P. 3076 - 3085

Published: June 25, 2024

infection is closely associated with gastrointestinal diseases. Our preliminary studies have indicated that

Language: Английский

Citations

4
Changes in gut microbiota affect DNA methylation levels and development of chicken muscle tissue DOI Creative Commons
Yibin Xu,

Yunpeng Huang,

Shenghua Wei

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104869 - 104869

Published: Feb. 6, 2025

The intestinal microbiome is essential in regulating host muscle growth and development. Antibiotic treatment commonly used to model dysbiosis of the microbiota, yet limited research addresses relationship between gut microbes yellow-feathered broilers. In this study, Xinghua chickens were administered broad-spectrum antibiotics for eight weeks induce suppression. We investigated relationships using 16S rRNA sequencing transcriptomic analysis. Results indicated that antibiotic significantly reduced body weight, dressed eviscerated breast leg weight. Microbial diversity richness duodenum, jejunum, ileum, cecum decreased. relative abundances Firmicutes, Actinobacteria, Bacteroidetes declined, while Proteobacteria increased. This microbial imbalance led 298 differentially expressed genes (DEGs) tissue, which 67 down-regulated enriched skeletal development, including MYF6, MYBPC1 METTL21C DEGs primarily involved MAPK signaling pathway, calcium ECM-receptor interaction, actin cytoskeleton regulation, nitrogen metabolism. Correlation analysis showed dysregulation cecal had most substantial effect on Furthermore, DNMT3b mRNA expression lowered overall DNA methylation SAM levels, induced changes impacted study demonstrates microbiota influence thereby associated with

Language: Английский

Citations

0
Relationship between Helicobacter pylori and hypertriglyceridemia in the population DOI
Yi Chen, Yi Wang,

Bingqian Ni

et al.

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Identification of Released Bacterial Extracellular Vesicles Containing Lpp20 from Helicobacter pylori DOI Creative Commons
Aoi Okamoto,

Tatsuki Shibuta,

N. Morita

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 753 - 753

Published: March 26, 2025

Helicobacter pylori is a pathogenic bacterium that causes gastric and extragastric diseases. We have previously demonstrated one of the mechanisms H. pylori-associated chronic immune thrombocytopenia involves complexes platelets, protein Lpp20 an anti-Lpp20 antibody. However, it remains unclear how enters body. hypothesize bacterial extracellular vesicles (bEVs) transport Lpp20. Thus, this study assessed in bEVs released from seven clinical isolates, using immunoprecipitation (IP), immunoblotting (IB), surface plasmon resonance imaging (SPRi), with anti-GroEL (a marker bEVs) antibodies. were each detected lysates all strains. IP–IB experiments containing produced by five strains (J99, SS1, HPK5, JSHR3, JSHR31). SPRi antibody significantly higher reflectance strain HPK5 than its lpp20-disrupted (p < 0.01), indicating localization on bEVs’ surface; may also be contained within bEVs. The not two (26695 JSHR6) or (26695ΔLpp20 HPK5ΔLpp20). Differences detection are likely due to variations bEV production resulting diversity.

Language: Английский

Citations

0
The influence of Helicobacter pylori infection on acute coronary syndrome and lipid metabolism in the Chinese ethnicity DOI Creative Commons

Yizhen Fang,

Chunming Fan,

Yun Li

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 3, 2024

Background Acute coronary syndrome (ACS) patients frequently present a relatively high prevalence of Helicobacter pylori ( H. ) infection. was previously hypothesized to induce ACS through the regulation lipid levels. However, risk -induced varies significantly among different ethnic groups, and associations between parameters remain unclear. This study aimed systematically assess in Chinese populations with infection while also evaluating effects on parameters. Materials methods A hospital-based case−control involving 280 participants conducted. Immunoblotting used for detection genotyping . The ACS, as well parameters, were analyzed via chi-square test multiple logistic regression model. Results increased all (adjusted odds ratio (OR) = 4.04, 95% confidence interval (CI): 1.76−9.25, P &lt; 0.05), no virulence factors cytotoxin-associated gene CagA or vacuole toxin geneA VacA )). Subgroup analysis revealed significant increase elderly population aged 56−64 years Additionally, substantial association observed acute myocardial infarction (AMI). No differences found including low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), total (TC), high-density (HDL-C), LDL/HDL ratio, individuals positive negative Similar results group control group. Conclusions Our has demonstrated first time that does not impact metabolism but increases fourfold (OR CI: 1.76−9.25). Furthermore, may be involved mechanisms by which they promote development ACS. finding provides additional evidence groups refutes biological mechanism affects regulation. Regular screening eradication treatment those at effective measures reducing incidence Future research should include multicenter randomized controlled trials explore host genetics gut microbiota potential pathways linking

Language: Английский

Citations

3
Azobenzenesulfonamide Carbonic Anhydrase Inhibitors as New Weapons to Fight Helicobacter pylori: Synthesis, Bioactivity Evaluation, In Vivo Toxicity, and Computational Studies DOI Creative Commons
Letizia Giampietro, Beatrice Marinacci,

Alice Della Valle

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1027 - 1027

Published: Aug. 5, 2024

Research into novel anti-

Citations

1
Oxidized yeast glucan alleviates lead-induced toxicity in mice by improving intestinal health to inhibit Pb absorption and reducing kidney oxidative stress DOI
Shuai Chen, Xinyi Zhu,

Yujie Guo

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139205 - 139205

Published: Dec. 1, 2024

Language: Английский

Citations

0
The Association between Helicobacter pylori Infection and Triglyceride-Glucose (TyG) Index in US Adults: a restrospective cross-sectional study DOI Creative Commons
Wei Fu, Junlong Zhao,

GuoBin Chen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 9, 2023

ABSTRACT Background The Triglyceride-glucose (TyG) index is an emerging marker for insulin resistance and metabolic syndrome. Helicobacter pylori, a bacterium associated with gastrointestinal diseases, may also influence risk profiles. This study aimed to investigate the relationship between TyG pylori infection among representative sample of adults. Methods A total 9965 participants from NHANES 1999-2000 cycle were involved March 1, 1999, December 2000.A cross-sectional analysis was conducted on 3797 participants. baseline characteristics according quartile evaluated.Multivariate binary logistic regression models constructed analyze independent effects infection. two-piecewise model used explore non-linear inflection point identified. Subgroup analyses performed assess trends effect sizes across different variables including age, sex, glucose levels, body mass (BMI), chronic kidney disease (CKD). Results Multivariate indicated linear infection, suggesting differential demonstrated significant interactions only few variables, all p-values interaction below 0.05. Conclusions suggests association infection.These findings have implications understanding influences guide targeted interventions at-risk populations.

Language: Английский

Citations

0