Development of Skin Diseases Treatment based on Exosome Derived from Plants, Humans, Medicinal Algae and Fungi DOI Open Access

Maria Beihaghia,

Reza Sahebi,

Mohammad Reza Beihaghi

et al.

Published: Dec. 1, 2023

Annually, millions of people worldwide are affected by skin diseases, and current therapeutic approaches have limited efficacy. Advances in the treatment exosomes led to development new methods that hold promising potential for improving options diseases. The aim this study is produce pharmaceutical cosmetic compounds based on conditions such as eczema, pigmentation disorders, sagging aging, cellular regeneration, increased moisture, prevention shedding, among others. This examines effects derived from plants, humans, medicinal algae, fungi treat Spectrophotometric analysis reveals presence nucleic acids proteins exosome samples, indicating their cargo composition. TEM micrographs demonstrate isolation process preserves integrity membrane crucial spherical structure functionality. DLS confirms isolated a size similar typical dimensions. MTT assays indicate concentration-dependent cytotoxic cells, with calculated IC50 representing significant decrease cell viability. Real-time PCR shows higher gene expression levels collagen I III, enhance synthesis. Tyrosinase enzyme demonstrates influence treatments pathways related melanin production. use various sources provides platform developing drugs Additionally, can be utilized autoimmune diseases cancer, transforming them into hopeful field research. Plant-derived environmentally friendly serve next generation drug delivery systems treating

Language: Английский

β-Glucan extracts as high-value multifunctional ingredients for skin health: A review DOI
Pedro Sousa, Diana Tavares‐Valente, Manuela Amorim

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 322, P. 121329 - 121329

Published: Aug. 23, 2023

Language: Английский

Citations

23
The efficacy of a novel tomato extracts formulation on skin aging and pigmentation: A randomized, double-blind, parallel-controlled trial DOI Creative Commons
Silu Zhang, Shan Lü, Yun Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100005 - 100005

Published: Jan. 30, 2024

Oxidative stress is a significant factor in skin aging and pigmentation, which can be precipitated by various circumstances. Antioxidants tyrosinase inhibitors, such as carotenoids, yeast extract (glutathione), sodium hyaluronate, astaxanthin, niacin, individually protect the against through distinct mechanisms. These mechanisms potentially enhance barrier improve signs of pigmentation. However, synergistic effects these compounds, found golden tomato formulation, have been scarcely explored. In this study, out all participants, 62 volunteers completed experiment were included statistical analysis. The results indicated that after eight weeks consuming research product, there no changes indicators within placebo group. contrast, treatment group receiving sample formulation exhibited 35.63% increase stratum corneum hydration 29.39% reduction transepidermal water loss (TEWL), suggesting enhanced hydration. Visual assessments revealed improvements color gloss index 15.03% 11.41%, respectively, Furthermore, individual typology angle (ITA) value increased 18.59% 6.36%, leading to lighter tone. Significant enhancements also observed uniformity, redness. After intervention with sample, blood levels superoxide dismutase (SOD) glutathione peroxidase (GPx) increased, while malondialdehyde (MDA) decreased. findings confirm continuous intake over effectively improved volunteers' whitening hydration, visibly brightened tone an antioxidant mechanism.

Language: Английский

Citations

5
Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil DOI Creative Commons
Suvimol Somwongin, Wantida Chaiyana

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 724 - 724

Published: April 20, 2024

This study aimed to assess natural oils for their antioxidant and anti-hyaluronidase properties select the most effective candidate development into nanoemulsions (NE) clinical evaluations. The were assessed using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+) ferric thiocyanate assays an enzyme-substrate reaction assay activity. potent oil was formulated conventional emulsions (CE) NE, which characterized evaluated stability, both in accelerated long-term conditions. irritation potential hen’s eggs chorioallantoic membrane test a trial. Skin hydration enhancement skin wrinkle reduction efficacy clinically assessed. Macadamia integrifolia exhibited significant potency as ABTS•+ radical scavenger, lipid peroxidation inhibitor, hyaluronidase inhibitor (p < 0.05). Both CE comprising 15% w/w oil, 5% Tween® 80 Span® 80, 80% DI water, found be optimal. NE with internal droplet size of 112.4 ± 0.8 nm, polydispersity index 0.17 0.01, zeta −31.5 1.0 mV, had good stability induced no irritation. enhanced reduced wrinkles human volunteers, while outstanding enhancement.

Language: Английский

Citations

4
Heteroatom-doped carbon dots from medicinal plants as novel biomaterials for as-use biomedical applications in comparison with synthetic drug, zaltoprofen DOI Creative Commons
K. Sobha,

Pradeep Dumpala,

S. Radhika

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 7, 2024

Abstract FN-doped carbon dots were synthesized using powdered leaves of Moringa oleifera L./ Chromolaena odorata Tridax procumbens Tinospora cordifolia and Lantana camara L., along with a precursor called 4,5-difluoro-1,2-benzenediamine (DFBD) compared against the drug zaltoprofen derived dots. They assessed for their optical structural characteristics photoluminescence (optimal emission λ 600 nm), vibrational (FTIR) spectroscopy (characteristic wave numbers 1156 1269 cm −1 C–F), as well X-ray diffraction (XRD) (highest intensity at 27.56°) high-resolution transmission electron microscopy (HR-TEM) (particles in size range 15–20 nm). Further, field scanning (FESEM) / energy dispersive (EDX) indicated FN doping oval/oblong Membrane protection percent is found to be 55.3 80.4 FN-CDs Z-FN-CDs respectively. The DPPH-free radical scavenging activity by was 69.4%, while Z-FN-CDs, it 54.2%. When tested on six bacterial strains (three each gram-positive gram-negative), displayed halo (ZOI) between 9 19 mm, whereas clearance zone 17 mm. showed significant emission-red-shift effects demonstrated concentration-dependent biocompatibility viability neuroblastoma beta-TC6-cell lines.

Language: Английский

Citations

4
Microemulsions Improve the Cutaneous Co-Localization of Lipoic Acid and Quercetin and Antioxidant Effects in Cutaneous Cells and Tissue DOI

Maria Isabella da Silva,

Julia S. Passos, Regina G. Daré

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)

Published: Feb. 26, 2025

Language: Английский

Citations

0
Foam-Based Drug Delivery Systems for Skin Disorders: A Comprehensive Review DOI
Syrsulu Myrzagulova,

Zhexenova Azhar N,

Mohit Kumar

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: April 4, 2025

Language: Английский

Citations

0
Three-channel imaging reveals the comprehensive protein modifications and their impact on skin appearance induced by multiple stimuli DOI
Wenjuan Liu, Shanshan Zhang, Yibin Wang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111182 - 111182

Published: April 1, 2025

Language: Английский

Citations

0
Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3: Efficient Combination of Bio-Stimulation Properties with Hydrogel System Resilience Enhancement DOI Creative Commons
Alexandre Porcello,

Michèle Chemali,

Cíntia Marques

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(6), P. 361 - 361

Published: May 24, 2024

Hyaluronic acid (HA) hydrogels are commonly used for facial dermal filling and alternative medical aesthetic purposes. High diversity exists in commercial formulations, notably the optimization of finished product stability, functionality, performance. Polyvalent ingredients such as calcium hydroxylapatite (CaHA) or vitamin B3 (niacinamide) bio-stimulants to improve skin quality attributes at administration site. The aim present study was perform multi-parametric characterization two novel cross-linked filler formulas (HAR-1 “Instant Refine” HAR-3 “Maxi Lift”) elucidation various functional impacts incorporation. Therefore, HAR products were firstly comparatively characterized terms vitro rheology, cohesivity, injectability, resistance chemical enzymatic degradation (exposition H2O2, AAPH, hyaluronidases, xanthine oxidase). Then, assessed cytocompatibility bio-stimulation a primary fibroblast model. results showed enhanced resilience cohesive compared JUVÉDERM® VOLBELLA® VOLUMA® reference controlled assay panel. Furthermore, significant induction total collagen synthesis cultures recorded HAR-1 HAR-3, denoting intrinsic bio-stimulatory effects comparable superior those Radiesse® Sculptra™ products. Original high translational relevance generated herein using robust orthogonal experimental methodologies (hydrogel degradation, benchmarking) designs. Overall, reported confirmed dual functionalization role HA fillers, with enhancement hydrogel system stability deployment potent capacities.

Language: Английский

Citations

3
The therapeutic potential of chia seeds as medicinal food: a review DOI
Peerzada Gh Jeelani, Bruce Joshua Sinclair,

Gopi Krishna Perinbarajan

et al.

Nutrire, Journal Year: 2023, Volume and Issue: 48(2)

Published: Aug. 2, 2023

Language: Английский

Citations

7
Plant Extract-Derived Carbon Dots as Cosmetic Ingredients DOI Creative Commons
Le Thi Nhu Ngoc,

Ju‐Young Moon,

Young‐Chul Lee

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(19), P. 2654 - 2654

Published: Sept. 27, 2023

Plant extract-derived carbon dots (C-dots) have emerged as promising components for sustainability and natural inspiration to meet consumer demands. This review comprehensively explores the potential applications of C-dots derived from plant extracts in cosmetics. paper discusses synthesis methodologies generation precursors, including pyrolysis carbonization, chemical oxidation, hydrothermal, microwave-assisted, ultrasonic methods. offer distinct advantages over conventional synthetic materials by taking advantage inherent properties plants, such antioxidant, anti-inflammatory, UV protective properties. These outstanding are critical novel cosmetic controlling skin aging, treatment inflammatory conditions, sunscreen. In conclusion, combine cutting-edge nanotechnology sustainable innovation, presenting an opportunity revolutionize industry offering enhanced while embracing eco-friendly practices.

Language: Английский

Citations

7