Interleukin-18 in Health and Disease

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(3), P. 649 - 649

Published: Feb. 2, 2019

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing which increase response to stimulation. Therefore, IL-12 is commitment induces development cells. In contrast, proinflammatory cytokine facilitates type 1 responses. However, without but IL-2, stimulates NK CD4+ NKT and established produce IL-3, IL-9, IL-13. Furthermore, together mast basophils IL-4, IL-13, chemical mediators such histamine. various cell types has pleiotropic functions. member IL-1 family cytokines. demonstrates unique function by binding specific expressed on this review article, we will focus features health disease experimental animals humans.

Language: Английский

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Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

Gastroenterology, Journal Year: 2016, Volume and Issue: 151(4), P. 616 - 632

Published: July 18, 2016

Language: Английский

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Physicochemical properties of mucus and their impact on transmucosal drug delivery

International Journal of Pharmaceutics, Journal Year: 2017, Volume and Issue: 532(1), P. 555 - 572

Published: Sept. 14, 2017

Mucus is a selective barrier to particles and molecules, preventing penetration the epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery have recently been made emphasized that an understanding basic structure, viscoelastic properties, interactions mucus great value design efficient systems. Mucins, primary non-aqueous component mucus, are polymers carrying complex heterogeneous structure with domains undergo variety molecular interactions, such as hydrophilic/hydrophobic, hydrogen bonds electrostatic interactions. These properties directly relevant numerous mucin-associated diseases, well delivering drugs across barrier. Therefore, this review we discuss regional differences composition, physicochemical pore size, viscoelasticity, pH, ionic strength. factors also discussed respect changes function disease state. Collectively, seeks provide state art roadmap for researchers who must contend critical delivery.

Language: Английский

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Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 106, P. 256 - 276

Published: Aug. 4, 2016

In this contribution, we review the molecular and physiological barriers to oral delivery of peptides nanoparticles. We discuss opportunities predictivity various in vitro systems with special emphasis on human intestine Ussing chambers. First, constraints peptide absorption are discussed. Then examined. These include gastric intestinal environment, mucus barrier, tight junctions between epithelial cells, enterocytes epithelium, subepithelial tissue. Recent data from proteome studies used provide information about protein expression profiles different nanoparticle absorption. Strategies that have been employed increase across each Special consideration is given attempts at utilizing endogenous transcytotic pathways. To reliably translate or permeability vivo situation a subject, experimental system needs realistically capture central aspects mentioned barriers. Therefore, characteristics common cell culture discussed compared those tissues. Attempts use tissue models for vitro–in extrapolation reviewed.

Language: Английский

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Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Microorganisms, Journal Year: 2021, Volume and Issue: 9(2), P. 353 - 353

Published: Feb. 11, 2021

The microbiome plays an important role in a wide variety of skin disorders. Not only is the altered, but also surprisingly many diseases are accompanied by altered gut microbiome. key regulator for immune system, as it aims to maintain homeostasis communicating with tissues and organs bidirectional manner. Hence, dysbiosis and/or associated response, promoting development diseases, such atopic dermatitis, psoriasis, acne vulgaris, dandruff, even cancer. Here, we focus on associations between microbiome, diet, metabolites, responses pathologies. This review describes exhaustive list common conditions well current body evidence dysbiosis, dietary links, their interplay conditions. An enhanced understanding local including underlying mechanisms necessary shed light microbial involvement human develop new therapeutic approaches.

Language: Английский

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Microscopic examination of spatial transcriptome using Seq-Scope

Cell, Journal Year: 2021, Volume and Issue: 184(13), P. 3559 - 3572.e22

Published: June 1, 2021

Language: Английский

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Current state and challenges in developing oral vaccines

Advanced Drug Delivery Reviews, Journal Year: 2017, Volume and Issue: 114, P. 116 - 131

Published: April 22, 2017

Language: Английский

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Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Gut, Journal Year: 2021, Volume and Issue: 71(4), P. 734 - 745

Published: May 18, 2021

Objective Programmed death 1 and its ligand (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be improved. Gut microbiota plays a crucial role in sensitisation Panax ginseng has been shown possess immunomodulatory potential. In this study, we aimed investigate whether combination treatment of polysaccharides (GPs) αPD-1 monoclonal antibody (mAb) could sensitise by modulating gut microbiota. Design Syngeneic mouse models were administered GPs mAb, sensitising antitumour effects therapy on assessed faecal transplantation (FMT) 16S PacBio single-molecule real-time (SMRT) sequencing. To assess immune-related metabolites, metabolomics analysis plasma samples was performed. Results We found increased mAb increasing microbial metabolites valeric acid decreasing L-kynurenine, as well ratio Kyn/Trp, which contributed suppression regulatory T cells induction eff after treatment. Besides, indicated that abundance Parabacteroides distasonis Bacteroides vulgatus higher responders anti-PD-1 blockade than non-responders clinic. Furthermore, sensitised PD-1 inhibitor mice receiving microbes FMT from six reshaping towards responders. Conclusion Our results demonstrate combined with may new strategy non-small cell patients immunotherapy. The can used novel biomarker predict

Language: Английский

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Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 19(2), P. 275 - 293

Published: July 28, 2023

Abstract The intestine is the largest interface between internal body and external environment. intestinal barrier a dynamic system influenced by composition of microbiome activity intercellular connections, regulated hormones, dietary components, inflammatory mediators, enteric nervous (ENS). Over years, it has become increasingly evident that maintaining stable crucial to prevent various potentially harmful substances pathogens from entering Disruption referred as 'leaky gut' or leaky gut wall syndrome seems be characterized release bacterial metabolites endotoxins, such lipopolysaccharide (LPS), into circulation. This condition, mainly caused infections, oxidative stress, high-fat diet, exposure alcohol chronic allergens, dysbiosis, appear highly connected with development and/or progression several metabolic autoimmune systemic diseases, including obesity, non-alcoholic fatty liver disease (NAFLD), neurodegeneration, cardiovascular disease, bowel type 1 diabetes mellitus (T1D). In this review, starting description mechanisms enable homeostasis analyzing relationship complex ecosystem pathological conditions, we explore role in driving inflammation, also shedding light on current future therapeutic interventions.

Language: Английский

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Intestinal Barrier in Human Health and Disease

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(23), P. 12836 - 12836

Published: Dec. 6, 2021

The intestinal mucosa provides a selective permeable barrier for nutrient absorption and protection from external factors. It consists of epithelial cells, immune cells their secretions. gut microbiota participates in regulating the integrity function homeostatic balance. Pathogens, xenobiotics food can disrupt barrier, promoting systemic inflammation tissue damage. Genetic factors predispose individuals to dysfunction, changes composition are central this process. progressive identification these has led development concept ‘leaky syndrome’ ‘gut dysbiosis’, which underlie relationship between impairment, metabolic diseases autoimmunity. Understanding mechanisms underlying process is an intriguing subject research diagnosis treatment various extraintestinal diseases.

Language: Английский

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