Emerging Innovations in Nanomedicine for Cancer Immunotherapy DOI
Jaimin R. Shah, Devesh U. Kapoor, Bhupendra G. Prajapati

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 104, P. 106584 - 106584

Published: Dec. 29, 2024

Language: Английский

Programmed cell death in tumor immunity: mechanistic insights and clinical implications DOI Creative Commons

Man Wang,

Fei Yu, Yuan Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 12, 2024

Programmed cell death (PCD) is an evolutionarily conserved mechanism of suicide that controlled by various signaling pathways. PCD plays important role in a multitude biological processes, such as turnover, development, tissue homeostasis and immunity. Some forms PCD, including apoptosis, autophagy-dependent death, pyroptosis, ferroptosis necroptosis, contribute to carcinogenesis cancer thus have attracted increasing attention the field oncology. Recently, research-based evidence has demonstrated acts critical modulator tumor can affect function innate adaptive immune cells, which leads distinct immunological consequences, priming tumor-specific T immunosuppression evasion. Targeting alone or combination with conventional immunotherapy may provide new options enhance clinical efficacy anticancer therapeutics. In this review, we introduce characteristics mechanisms ubiquitous pathways (e.g., pyroptosis ferroptosis) explore complex interaction between these immunity based on currently available evidence. We also discuss therapeutic potential PCD-based approaches outlining trials targeting treatment. Elucidating immune-related effects pathogenesis will likely improved understanding oncoimmunology allow be exploited for

Language: Английский

Citations

9
Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hot DOI Creative Commons

Yiman Han,

Xin Tian,

Jiaqi Zhai

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: May 7, 2024

Immunotherapy has emerged as a promising cancer treatment option in recent years. In immune “hot” tumors, characterized by abundant cell infiltration, immunotherapy can improve patients’ prognosis activating the function of cells. By contrast, “cold” tumors are often less sensitive to owing low immunogenicity tumor cells, an inhibitory microenvironment, and series immune-escape mechanisms. Immunogenic death (ICD) is cellular process facilitate transformation eliciting innate adaptive responses through release (or exposure to) damage-related molecular patterns. Accumulating evidence suggests that various traditional therapies induce ICD, including chemotherapy, targeted therapy, radiotherapy, photodynamic therapy. this review, we summarize biological mechanisms hallmarks ICD introduce some newly discovered technologically innovative inducers activate system at level. Furthermore, also discuss clinical applications combing with immunotherapy. This review will provide valuable insights into future development ICD-related combination therapeutics potential management for tumors.

Language: Английский

Citations

9
Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer DOI Creative Commons

Yuwei Yao,

Jiarui Zhang,

Kexin Huang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 5, 2025

The efficacy of current therapies for ovarian cancer is limited due to the multilevel and complex tumor microenvironment (TME), which induces drug resistance progression in a single treatment regimen. Additionally, poor targeting insufficient tissue penetration are important constraints treatment. We constructed PH20-overexpressing cancer-associated fibroblast (CAF)-cancer hybrid-cell membrane vesicles (PH20/CCM) dual-targeted delivery carboplatin (CBP) siRNA p65 (sip65) loaded on poly (dimethyl diallyl ammonium chloride) (PDDA)-modified MXene (PMXene), named PMXene@CBP-sip65 (PMCS). nanoparticle PH20/CCM@PMCS could penetrate extracellular matrix tissues target both cells CAFs. After cell internalization, these nanoparticles significantly inhibited proliferation, generated reactive oxygen species, induced endoplasmic reticulum stress, triggered immunogenic death. CAF they pro-tumor factor release activated immune effects, promoting system infiltration. In an experiment with ID8 homograft-carrying mice, improved inhibition enhanced infiltration tissues. These new therapeutic can simultaneously cells, CAFs, matrix, thereby increasing sensitivity improving TME. Therefore, TME-regulating nanoparticles, combining specificity, efficiency, effectiveness, provide insights into

Language: Английский

Citations

1
Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death DOI
Rama Rao Malla,

Seema Kumari,

Swapna Priya Ganji

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189154 - 189154

Published: July 15, 2024

Language: Английский

Citations

7
Immunogenic cell stress and death in the treatment of cancer DOI Creative Commons
Hui Pan, Peng Liu, Liwei Zhao

et al.

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 156, P. 11 - 21

Published: Nov. 16, 2023

Language: Английский

Citations

11
Shifting cold to hot tumors by nanoparticle-loaded drugs and products DOI
Irfan Ahmad,

Kamil K. Atiyah Altameemi,

Mohaned Mohammed Hani

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Language: Английский

Citations

4
DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications DOI Open Access
Bingyu Lin, Yanfei Liu, Qi‐Wen Chen

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Current tumor vaccines suffer from inadequate immune responsive due to the insufficient release of antigens, low infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability precisely engineer, controlled release, biocompatibility, capability augment immunogenicity microenvironment, have gained significant attention for potential revolutionize vaccine designing. This review summarizes various applications in construction situ cancer vaccines, which can generate tumor‐associated antigens directly damaged tumors immune‐stimulation. The mechanisms components are listed, specific strategies constructing using explored underlying action elucidated. immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic (PDT), radiation (RT) related building systematically summarized. different immunotherapy elaborated, exerts precise, long‐lasting, robust responses. current challenges future prospectives proposed. provides a holistic understanding evolving role development.

Language: Английский

Citations

0
Impact of radiation therapy on the immunological tumor microenvironment DOI
Emma Guilbaud,

Flavie Naulin,

Lydia Meziani

et al.

Cell chemical biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Immunological signatures from irradiated cancer-associated fibroblasts DOI Creative Commons

Rodrigo Berzaghi,

Kristian Gundersen,

Brede Dille Pedersen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 6, 2024

Cancer-associated fibroblasts (CAFs) are abundant and influential elements of the tumor microenvironment (TME), giving support to development in multiple ways. Among other mechanisms, CAFs important regulators immunological processes occurring tumors. However, CAF-mediated immunomodulation context radiotherapy remains poorly understood. In this study, we explore effects radiation on CAF-derived immunoregulatory signals TME.

Language: Английский

Citations

3
Innovative hydrogel-based delivery systems for immunotherapy: A review of pre-clinical progress DOI
Narsimha Mamidi, Michael J. Poellmann,

Kaila Javius-Jones

et al.

Nano Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

Citations

2