The role of ageing and oxidative stress in intervertebral disc degeneration DOI Creative Commons
Pengfei Wen,

Bolong Zheng,

Bin-Fei Zhang

et al.

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 7, 2022

Intervertebral disc degeneration (IDD) is the primary cause of intervertebral (IVD) disease. With increased ageing society, an increasing number patients are plagued by Ageing not only accelerates decreased vitality and functional loss cells but also increases intracellular oxidative stress. Moreover, speed linked to high levels reactive oxygen species (ROS) production. Not production ROS in cells, antioxidant degenerative discs decrease. In addition disc, structural components matrix vulnerable damage. After chronic mitochondrial dysfunction, can be produced large quantities, while autophagy eliminate these impaired mitochondria reduce ROS. Oxidative stress has a marked impact on occurrence IDD. future, IDD treatment aiming improve regulating redox balance cells. summary, promote IVD, further basic clinical trials needed determine how treat At present, although there many in-depth studies relationship between specific mechanism been elucidated. this paper, main causes diseases studied summarized, studied.

Language: Английский

Mitochondrial quality control in intervertebral disc degeneration DOI Creative Commons
Yu Song, Saideng Lu, Wen Geng

et al.

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(7), P. 1124 - 1133

Published: July 1, 2021

Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the human lifespan that can increase risk of low back pain. More clarification molecular mechanisms associated with onset progression IDD likely to help establish novel preventive therapeutic strategies. Recently, mitochondria have been increasingly recognized as participants regulating glycolytic metabolism, which has historically regarded main metabolic pathway intervertebral discs due their avascular properties. Indeed, mitochondrial structural functional disruption observed degenerated nucleus pulposus (NP) cells discs. Multilevel well-orchestrated strategies, namely, quality control (MQC), are involved maintenance integrity, proteostasis, antioxidant system, dynamics, mitophagy, biogenesis. Here, we address key evidence current knowledge role function process consider how MQC strategies contribute protective detrimental properties NP cell function. The relevant potential treatments targeting for intervention also summarized. Further synergistic among may provide useful clues use developing treatments.

Language: Английский

Citations

76
Mitochondrial Dysfunction in Oxidative Stress‐Mediated Intervertebral Disc Degeneration DOI

D. Wang,

Huo‐Liang Zheng,

Wen‐Sheng Zhou

et al.

Orthopaedic Surgery, Journal Year: 2022, Volume and Issue: 14(8), P. 1569 - 1582

Published: June 8, 2022

Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain (LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) play an important role in IVDD. As a by‐product of aerobic respiration, ROS mainly produced mitochondria by electron transport chain other mitochondrial located proteins. With excessive accumulation ROS, are also primary target attack cells. A disrupted balance between intracellular production antioxidant capacity will lead stress, which key cell apoptosis, senescence, autophagy, dysfunction. pivotal ingredient dysfunction manifests as imbalanced dynamics dysregulated mitophagy. Mitochondria can alter their own through process fusion fission, so disabled be separated from pool. Moreover, mitophagy participates clearing these dysfunctional mitochondria. Abnormality any processes either increases or decreases clearance leading vicious cycle results death intervertebral cells large quantities, combined with degradation extracellular matrix overproduction metalloproteinase. In this review, we explain changes morphology function during stress‐mediated IVDD highlight process. Eventually, summarize therapeutic strategies targeting based on current understanding

Language: Английский

Citations

53
The potential influence of melatonin on mitochondrial quality control: a review DOI Creative Commons
Xudan Lei,

Zhenni Xu,

Lingxiao Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Mitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of homeostasis functional recovery after injury coordinated by biogenesis, dynamics autophagy, which collectively referred to as quality control. There increasing evidence that mitochondria important targets melatonin exert protective effects under pathological conditions. Melatonin, an evolutionarily conserved tryptophan metabolite, can be synthesized, transported metabolized in mitochondria. In this review, we summarize the role damaged elimination energy supply regulating control, may provide new strategies clinical treatment mitochondria-related diseases.

Language: Английский

Citations

11
Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies DOI Creative Commons
Hao Zhou,

Chenyu Wu,

Yuxin Jin

et al.

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 49, P. 181 - 206

Published: Oct. 16, 2024

Language: Английский

Citations

11
MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression DOI Creative Commons
Liang Ma, Xiangyu Meng,

Tuerhongjiang Abudurexiti

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

Citations

1
Mfn2 is involved in intervertebral disc degeneration through autophagy modulation DOI Creative Commons

Y Chen,

Jialiang Lin, Junhui Chen

et al.

Osteoarthritis and Cartilage, Journal Year: 2020, Volume and Issue: 28(3), P. 363 - 374

Published: Jan. 8, 2020

Language: Английский

Citations

64
<p>Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells</p> DOI Creative Commons
Jinjing Wu, Yanli Yang, Yafen Gao

et al.

Drug Design Development and Therapy, Journal Year: 2020, Volume and Issue: Volume 14, P. 2047 - 2060

Published: May 1, 2020

Autophagy caused by ischemia/reperfusion (I/R) increases the extent of cardiomyocyte damage. Melatonin (Mel) diminishes cardiac injury through regulating autophagy and mitochondrial dynamics. However, illustrating specific role mitophagy in cardioprotective effects melatonin remains a challenge. The aim our research was to investigate impact underlying mechanisms connection with during anoxia/reoxygenation (A/R) H9c2 cells.H9c2 cells were pretreated or without membrane receptor 2 (MT2) antagonist 4-P-PDOT, MT2 agonist IIK7 sirtuin 3 (SIRT3) inhibitor 3-TYP for 4 hours then subjected A/R injury. Cell viability, cellular apoptosis, necrosis levels oxidative markers assessed. expression SIRT3 forkhead box O3a (FoxO3a), function mitophagy-related proteins also evaluated.A/R provoked enhanced myocytes. In addition, increased correlated decreased stress dysfunction cells. pretreatment notably cell survival apoptosis response after injury, accompanied restored function. inhibition excessive is involved melatonin, as shown molecules Parkin, Beclin1, BCL2-interacting protein 3-like (BNIP3L, best known NIX) light chain II/light I (LC3 II/LC3 I) ratio upregulation p62 expression. Moreover, FoxO3a A/R-injured abrogated but these beneficial attenuated 4-P-PDOT IIK7.These results indicate that protects suppressing activating MT2/SIRT3/FoxO3a pathway. may be useful candidate alleviating myocardial (MI/R) future, might become therapeutic target.

Language: Английский

Citations

62
Sleep-Wake Disorders: Definition, Contexts and Neural Correlations DOI Open Access
Perrotta Giulio

Journal of Neurology and Psychology, Journal Year: 2019, Volume and Issue: 7(1), P. 01 - 09

Published: Dec. 12, 2019

Starting from the macro-category "sleep-wake disorders", as defined in DSM-V, individual pathological conditions were defined, focusing on contextual and clinical aspects, to continue analysis neural correlates strategic therapy be used solve problems encountered.

Language: Английский

Citations

58
Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19 DOI Creative Commons
Dun‐Xian Tan, Rüdiger Hardeland

Molecules, Journal Year: 2020, Volume and Issue: 25(19), P. 4410 - 4410

Published: Sept. 25, 2020

Fighting infectious diseases, particularly viral infections, is a demanding task for human health. Targeting the pathogens or targeting host are different strategies, but with an identical purpose, i.e., to curb pathogen’s spreading and cure illness. It appears that increase tolerance against can be of substantial advantage strategy used in evolution. Practically, it has broader protective spectrum than only specific pathogens, which differ terms susceptibility. Methods applied one pandemic even effective upcoming pandemics pathogens. This more urgent if we consider possible concomitance two respiratory diseases potential multi-organ afflictions such as Coronavirus disease 2019 (COVID-19) seasonal flu. Melatonin molecule enhance host’s pathogen invasions. Due its antioxidant, anti-inflammatory, immunoregulatory activities, melatonin capacity reduce severity mortality deadly virus infections including COVID-19. synthesized functions mitochondria, play critical role infections. Not surprisingly, synthesis become target strategies manipulate mitochondrial status. For example, infection switch energy metabolism from respiration widely anaerobic glycolysis plenty oxygen available (the Warburg effect) when cell cannot generate acetyl-coenzyme A, metabolite required biosynthesis. Under some conditions, aging, gender, predisposed health already compromised exposed further challenges, lose their producing sufficient amounts melatonin. leads reduced support makes these individuals vulnerable diseases. Thus, maintenance function by supplementation expected beneficial effects on outcome

Language: Английский

Citations

55
Natural ingredients-derived antioxidants attenuate H2O2-induced oxidative stress and have chondroprotective effects on human osteoarthritic chondrocytes via Keap1/Nrf2 pathway DOI

Junjun Yang,

Xiongbo Song,

Yong Feng

et al.

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 152, P. 854 - 864

Published: Jan. 31, 2020

Language: Английский

Citations

54