SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 106957 - 106957

Published: Oct. 10, 2023

SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD

Language: Английский

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Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3370 - 3370

Published: March 16, 2024

Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had renewed interest in natural-products-based drug discovery. The quest new potential secondary metabolites or enhanced activities existing molecules remains pertinent topic research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin seeds, are primary of this compound. is known possess potent anti-inflammatory, antiproliferative, immunoregulatory properties. Among notable bioactivities associated with resveratrol, its pivotal role safeguarding intestinal barrier highlighted capacity prevent inflammation regulate gut microbiome. A better understanding how oxidative stress can be controlled using resveratrol capability protect microbiome perspective shed more light on physiological conditions. Additionally, exhibits antitumor activity, proving cancer treatment prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, neuroprotective benefits also reported. pharmaceutical industry continues encounter difficulties administering owing inadequate bioavailability poor solubility, which must addressed simultaneously. This report summarizes currently available literature unveiling pharmacological effects resveratrol.

Language: Английский

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Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level

Journal of Cellular and Molecular Medicine, Journal Year: 2022, Volume and Issue: 26(15), P. 4216 - 4229

Published: July 5, 2022

Myocardial ischemia/reperfusion injury (MI/RI) is the main cause of deaths in worldwide, leading to severe cardiac dysfunction. Resveratrol (RSV) a polyphenol plant-derived compound. Our study aimed elucidate underlying molecular mechanism preconditioning RSV protecting against MI/RI. Mice were ligated and re-perfused by left anterior descending branch with or without (30 mg/kg·ip) for 7 days. Firstly, we found that pretreatment significantly alleviated myocardial infarct size, improved function decreased oxidative stress. Furthermore, activated p-AMPK SIRT1, ameliorated inflammation including level TNF-α IL-1β, promoting autophagy level. Moreover, neonatal rat ventricular myocytes (NRVMs) H9c2 cells knockdown expression AMPK, SIRT1 FOXO1 used uncover cardio-protection RSV. In NRVMs, increased cellular viability, LDH release reduced Importantly, Compound C(CpC) EX527 reversed effect MI/RI vivo vitro counteracted induced Together, our indicated could alleviate stress cardiomyocytes through activating AMPK/SIRT1-FOXO1 signallingpathway enhanced level, thus presenting high potential protection on

Language: Английский

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Pharmacological effects of salidroside on central nervous system diseases

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113746 - 113746

Published: Oct. 10, 2022

Language: Английский

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Resveratrol as a privileged molecule with antioxidant activity

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100539 - 100539

Published: Nov. 21, 2023

Oxidative stress has a significant impact on the occurrence of many chronic diseases. Antioxidants have ability to prevent, postpone or treat effects free radicals. Resveratrol is polyphenol from class stilbenes. The importance this compound determined by its numerous biological properties. strong antioxidant potential special significance, because way it acts in prevention and treatment action direct, inhibiting production reactive species, indirect, influencing activity enzymes. In case analyzing known methods, was observed that RSV had higher capacity than standard used. Also, vitro vivo studies demonstrate neurodegenerative, cardiovascular renal addition, active preeclampsia infertility. An important aspect fact reduce counteract adverse some anticancer agents.

Language: Английский

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Resveratrol inhibits autophagy against myocardial ischemia-reperfusion injury through the DJ-1/MEKK1/JNK pathway

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 951, P. 175748 - 175748

Published: May 5, 2023

Language: Английский

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Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway

Biogerontology, Journal Year: 2024, Volume and Issue: 25(4), P. 649 - 664

Published: April 9, 2024

Abstract Skin photoaging is mostly caused by ultraviolet A (UVA), although active medications to effectively counteract UVA-induced have not yet been created. Resveratrol, a naturally occurring polyphenol found in the skin of grapes, has shown various biological functions such as anti-inflammatory and antioxidant characteristics. However, role resveratrol clarified. We investigated mechanism action UVA irradiation human fibroblasts (HSF) innovatively modified mouse model photoaging. The results demonstrated that promoted AMP-activated protein kinase (AMPK) phosphorylation activate autophagy, reduce reactive oxygen species (ROS) production, inhibit apoptosis, restore normal cell cycle alleviate In addition, subcutaneous injection only improved symptoms roughness, erythema, increased wrinkles photodamaged mice, but also alleviated epidermal hyperkeratosis hyperpigmentation, reduced inflammatory responses, inhibited collagen fiber degradation. conclusion, our studies proved can treat elucidated possible molecular mechanisms involved, providing new therapeutic strategy for future anti-aging.

Language: Английский

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Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 971, P. 176524 - 176524

Published: March 30, 2024

Language: Английский

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Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 915 - 915

Published: Jan. 22, 2025

Polyphenols are micronutrients found in fruits, vegetables, tea, coffee, cocoa, medicinal herbs, fish, crustaceans, and algae. They can also be synthesized using recombinant microorganisms. Interest plant-derived natural compounds has grown due to their potential therapeutic effects with minimal side effects. This is particularly important as the aging population faces increasing rates of chronic diseases such cancer, diabetes, arthritis, cardiovascular, neurological disorders. Studies have highlighted polyphenols’ capacity reduce risk factors linked onset illnesses. narrative review discusses polyphenol families metabolism, cardioprotective polyphenols evidenced from vitro studies, well vivo on different animal models cardiac disease. study explores molecular mechanisms underlying these benefits. Current research suggests that may protect against ischemia, hypertension, hypertrophy, heart failure, myocardial injury through complex mechanisms, including epigenetic genomic modulation. However, further studies under nutritionally physiologically relevant conditions, untargeted multigenomic approaches, needed more comprehensively elucidate firmly prove polyphenols.

Language: Английский

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Revisiting Resveratrol as an Osteoprotective Agent: Molecular Evidence from In Vivo and In Vitro Studies

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1453 - 1453

Published: May 16, 2023

Resveratrol (RSV) (3,5,4′-trihydroxystilbene) is a stilbene found in abundance berry fruits, peanuts, and some medicinal plants. It has diverse range of pharmacological activities, underlining the significance illness prevention health promotion. The purpose this review was to delve deeper into RSV’s bone-protective properties as well its molecular mechanisms. Several vivo studies have effects RSV postmenopausal, senile, disuse osteoporosis rat models. been shown inhibit NF-κB RANKL-mediated osteoclastogenesis, oxidative stress, inflammation while increasing osteogenesis boosting differentiation mesenchymal stem cells osteoblasts. Wnt/β-catenin, MAPKs/JNK/ERK, PI3K/AKT, FoxOs, microRNAs, BMP2 are among possible kinases proteins involved underlying also be most potent SIRT1 activator cause stimulatory on osteoblasts inhibitory osteoclasts. may, thus, represent novel therapeutic strategy for bone growth reducing loss elderly postmenopausal population.

Language: Английский

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