Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(9), P. 2236 - 2252
Published: Jan. 1, 2024
Plant-derived exosomes (PDEs) show promising potential to be developed as a therapeutic agent against cancer, owing their multiple advantages such low toxicity, biocompatibility, availability, affordability, etc.
Language: Английский
Citations
27Cancer diagnosis using label-free SERS-based exosome analysis
Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 1966 - 1981
Published: Jan. 1, 2024
Exosomes, carrying distinctive biomolecules reflective of their parent cell's status and origin, show promise as liquid biopsy biomarkers for cancer diagnosis. However, clinical translation remains challenging due to relatively low concentration in body fluids. Surface-Enhanced Raman spectroscopy (SERS) has recently gained significant attention a label-free sensitive technique exosome analysis. This review explores SERS detection, covering isolation characterization methods, advancements substrates, fingerprint analysis techniques using machine learning. Furthermore, we emphasize the challenges offer insights into future prospects SERS-based enhance
Language: Английский
Citations
24Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 13, 2025
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.
Language: Английский
Citations
16Exosome and
Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(11), P. 1603 - 1607
Published: May 15, 2023
This short communication will enlighten the readers about exosome and epithelial-mesenchymal transition (EMT) related to several complicated events. It also highlighted therapeutic potential of exosomes against EMT. Exosome toxicology, heterogeneity, a single profiling approach are covered in this article. In future, could help us get closer cancer vaccine precision oncology.
Language: Английский
Citations
25Clinical Impact of Exosomes in Colorectal Cancer Metastasis
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 2576 - 2590
Published: June 14, 2023
Cancer is a complex deadly disease that has caused global health crisis in recent epochs. Colorectal cancer (CRC) the third most common malignant gastrointestinal disease. It led to high mortality due early diagnostic failure. Extracellular vesicles (EVs) come with promising solutions for CRC. Exosomes (a subpopulation of EVs) play vital role as signaling molecules CRC tumor microenvironment. secreted from all active cells. Exosome-based molecular transport (DNA, RNA, proteins, lipids, etc.) transforms recipient cell's nature. In CRC, cell-derived exosomes (TEXs) regulate multiple events development and progression such immunogenic suppression, angiogenesis, epithelial–mesenchymal transitions (EMT), physical changes extracellular matrix (ECM), metastasis. Biofluid-circulated tumor-derived are potential tool liquid biopsy. colorectal detection creates great impact biomarker research. The exosome-associated theranostics approach state-of-the-art method. this review, we address associated progression, on screening (diagnostic prognostic biomarkers), also highlight several clinical trials, well future directions exosome-based Hopefully, it will encourage researchers develop theranostic fight
Language: Английский
Citations
25Exosomes Barcoding: A smart approach for cancer liquid biopsy
The Journal of Liquid Biopsy, Journal Year: 2023, Volume and Issue: 2, P. 100129 - 100129
Published: Nov. 26, 2023
Cancer is an unsolved health crisis worldwide. Extracellular vesicles (EVs) address this problem in a new way. In cancer, early detection highly challenging, exosomes (a subpopulation of EVs, originating from endosomes) overcome limitation. tumor-derived (TEXs) play role as signaling molecules cancer development and progression. TEXs required more detailed investigation for specific biomarkers research. Exosome heterogeneity (some the facts regulate it such exosome size, origin, inner molecular diversity) made complication liquid biopsy. Single profiling barcoding support overcoming limitation developing precision oncology. interdisciplinary approach screening specifically.
Language: Английский
Citations
25Decoding of exosome heterogeneity for cancer theranostics
Clinical and Translational Medicine, Journal Year: 2023, Volume and Issue: 13(6)
Published: June 1, 2023
Extracellular Vesicles (EVs) discovery establishes a new milestone in cancer research. It explains biology way. EVs classified some significant subclasses such as macrovesicle (originated from plasma membrane), apoptotic bodies the membrane and endoplasmic reticulum), exosomes endosomes).1 The theranostic signature of healing is impressive, but its heterogeneity leads most complicated domain Therefore we comment on decoding exosome for future efficiency effective theranostics development. are cell-secreted one important entities. attracted much attention due to versatile uses. Overall, participation intercellular communication inner cargos (DNA, RNA, proteins, lipids glycan)2 can reprogram recipient cells. In addition, it also shows healthy or pathologic complication status parent cancer, tumor interlink complex chapter biology. Exosomes play an role accelerated growth, immune cell reprogramming,2 angiogenesis,3 extracellular matrix remodelling,4, 5 metastasis,4, epithelial-mesenchymal transition (EMT),4, organ-specific metastasis,5, 6 drug resistance stem development.3, 4 Clinically aspect, source biomarkers.7-9 Exosome heterogeneity1 evolving into major conflict biomarker therapeutic research.10 (Figure 1) based several facts origin, size, quantity, internal molecular diversity.1 size distribution side tumor-derived (TEXs). Scientific evidence that same cells release differently-sized exosomes. This size-oriented biodiversity reflected using different isolation methods.9, 10 more compared higher depends factors, exposures, hypoxic conditions, senescence. functional diversity related surface expression All these complicated/complex parameters lead challenging ecosystem development exosome-based theragnostics (combination biomarkers therapeutics research). scenario requires solution solve challenges. Based innovative nano platform-based approaches transform challenges opportunity researcher detailed exploration exosome.11 isolation, quantity solved via microfluidic device, fluorescence antibody tracking, Nanoparticle tracking analysis (NTA) (above 60 nm application),12, 13 magnetic resonance principle single screening,1 advanced sensitive flow cytometry (it capable separation subpopulation) electrophoresis chip. Molecular profiling critical tasks revealing bioactive cargo molecules Droplet digital polymerase chain reaction detection rear mutations exosomes),1 technology combined with chip system, electrochemical principle-based micro RNA explain dimension.1 downstream process needs muti-omics approach proper understand.1 combines machine learning precision marker development.14 technological advancements support constructing next-generation promising era exosomes.15, 16 Finally, opens door medicine17 vaccines18 cancer. We hope this article encourages large-scale EV research explore medicine Not applicable. authors declare no interest. There funding study.
Language: Английский
Citations
24Exosome DNA: An untold story of cancer
Clinical and Translational Discovery, Journal Year: 2023, Volume and Issue: 3(4)
Published: June 29, 2023
Abstract Exosome is nanosized tiny membrane‐bound vesicles and a subpopulation of extracellular (EVs). In general, it participates in intercellular communication acts as messenger several pathological complications. cancer interlink the most exciting domain current research. The internal molecular cargos (proteins, lipids, metabolites, miRNA, DNA) tumor derived exosomes (TEXs) are capable transforming normal cells into phenotypes. DNA less explored area EVs It involved events progression such uncontrol cell growth, reprogramming immune cells, metastasis, therapeutic resistance. Exo‐DNA also epigenetic alteration, which promotes cancer. has great impact on theranostics (biomarker therapeutics) Exo‐DNA‐based examination supports more detailed
Language: Английский
Citations
24Theranostic signature of tumor-derived exosomes in cancer
Medical Oncology, Journal Year: 2023, Volume and Issue: 40(11)
Published: Oct. 5, 2023
Language: Английский
Citations
24Fusion of Exosomes and Nanotechnology: Cutting-Edge Cancer Theranostics
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8489 - 8506
Published: April 15, 2024
Cancer is the most challenging health complication worldwide. Scientific society has tried to decode its complications and developing a smart solution for mankind. Extracellular vesicles (EVs) are an emerging frontier in cancer research. EVs provide fresh insight into understanding of released from all active cells. classified some major classes, such as apoptotic bodies, microvesicles, exosomes. Exosomes among exciting tools current research they work cellular messengers (which reflects cell's healthy or pathological conditional status). In tumor microenvironment, regulate several complicated events uncontrolled cell growth, immune suppression, angiogenesis, extracellular matrix remodeling, metastasis, organ-specific drug therapeutic resistance, stem development. also source promising biomarkers involved both diagnosis prognosis performs role. Exosomes-based nanomedicine which application nanosize theranostics sensor orientation, supports overcoming management limitations, early therapeutics specific, effective, affordable. this review, we have highlighted integration exosomes nanotechnology cutting-edge approach precision oncology.
Language: Английский
Citations
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