Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155747 - 155747
Published: Nov. 28, 2024
Language: Английский
The Journal of Liquid Biopsy, Journal Year: 2024, Volume and Issue: 3, P. 100138 - 100138
Published: Jan. 4, 2024
Extracellular vesicles (EVs) are the cell's secreted component. It is majorly classified into microvesicles, apoptotic bodies, and exosomes. Exosomes play a significant role in cancer development progression. Its molecular signature (DNA, RNA, Proteins, lipids) has more priority profiling current decade. In prevention, most challenging part early detection. EVs-based screening develops promising platform. Multi-Omics exosomes profiling-based liquid biopsy support detection efficient way. This approach provides detailed expression data (it may be inner cargos or surface express molecules). article highlited multi-omic exosome theranostics applications cancer, technical challenges, improvisation for future improvement.
Language: Английский
Citations
16
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8489 - 8506
Published: April 15, 2024
Cancer is the most challenging health complication worldwide. Scientific society has tried to decode its complications and developing a smart solution for mankind. Extracellular vesicles (EVs) are an emerging frontier in cancer research. EVs provide fresh insight into understanding of released from all active cells. classified some major classes, such as apoptotic bodies, microvesicles, exosomes. Exosomes among exciting tools current research they work cellular messengers (which reflects cell's healthy or pathological conditional status). In tumor microenvironment, regulate several complicated events uncontrolled cell growth, immune suppression, angiogenesis, extracellular matrix remodeling, metastasis, organ-specific drug therapeutic resistance, stem development. also source promising biomarkers involved both diagnosis prognosis performs role. Exosomes-based nanomedicine which application nanosize theranostics sensor orientation, supports overcoming management limitations, early therapeutics specific, effective, affordable. this review, we have highlighted integration exosomes nanotechnology cutting-edge approach precision oncology.
Language: Английский
Citations
14
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3657 - 3675
Published: April 1, 2024
Abstract: Exosomes are extracellular vesicles that originate from various cells and mediate intercellular communication, altering the behavior or fate of recipient cells. They carry diverse macromolecules, such as lipids, proteins, carbohydrates, nucleic acids. Environmental stressors can change exosomal contents many cells, making them useful for diagnosing chronic disorders, especially neurodegenerative, cardiovascular, cancerous, diabetic diseases. Moreover, exosomes be engineered therapeutic agents to modulate disease processes. State-of-art techniques employed separate including ultracentrifugation, size-exclusion chromatography immunoaffinity. However, modern technologies aqueous two-phase system well microfluidics gaining attention in recent years. The article highlighted composition, biogenesis, implications exosomes, standard novel methods isolating applying biomarkers cargo carriers. Keywords: Exosomes, vesicles, biomarkers, carriers, separation
Language: Английский
Citations
12
Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(1)
Published: Jan. 28, 2024
Abstract The epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing central role the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into complexities EMT, process where cancer cells gain exceptional mobility, facilitating their invasion distant organs and establishment secondary malignancies. We thoroughly examine myriad factors influencing encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions intricate dynamics tumour microenvironment. Particularly, emphasises advanced stages crucial for development highly aggressive phenotypes. During this phase, penetrate vascular barrier exploit bloodstream to propagate life‐threatening metastases through mesenchymal–epithelial transition. also explore EMT's significant fostering dormancy, senescence, emergence stem formidable challenge therapeutic resistance. Our transcends mere inventory EMT‐inducing elements; it critically assesses current state EMT‐focused clinical trials, revealing both hurdles breakthroughs. Highlighting potential EMT research, we project its transformative impact on future therapy. exploration is aimed at paving way towards an era effectively managing relentless disease, positioning forefront innovative research strategies.
Language: Английский
Citations
11
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2128 - 2139
Published: April 3, 2024
Cancer research has made significant progress in recent years, and extracellular vesicles (EVs) based cancer investigation reveals several facts about cancer. Exosomes are a subpopulation of EVs. In the present decade, exosomes is mostly highlighted for theranostic research. Tumor cell derived (TEXs) promote but there multiple sources that can be used as therapeutic agents (plant exosomes, stem cell-derived modified or synthetic exosomes). Stem cells regenerative medicine faces numerous challenges, such tumor development, cellular reprogramming etc., therefore addressing these complications becomes essential. serves an answer to problems offers better solution. Global indicates also play dual role system by either inhibiting promoting Modified which genetically engineered surface increase efficacy properties considered target above concerns. However, difficulties associated with include variations heterogenity, isolation protocols, large scale production, have managed effectively. this review, we explore biogenesis, exosome sources, drug delivery, clinical trial related challenges domain future orientation. This article may encourage researchers develop effective affordable
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 152067 - 152067
Published: May 9, 2024
Language: Английский
Citations
9
The Journal of Liquid Biopsy, Journal Year: 2024, Volume and Issue: 3, P. 100139 - 100139
Published: Jan. 5, 2024
Recent advances in cancer treatment emphasize the pivotal role of extracellular vesicles (EVs), especially exosomes (a subpopulation EVs, originating from endosomes). Exosomes are signaling molecules cellular system. Its molecular signature displays status cell (cell healthy or undergoing any clinical complication). frontiers upcoming theranostics era. This article highlighted exosome complex interlink, advantage exosome-base liquid biopsy, effectiveness exosome-based cell-free therapy compared to therapy, complications research, and its solution. Hope, this motivated researchers explore precision oncology
Language: Английский
Citations
6
Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(4)
Published: July 17, 2024
Abstract Exosomes are nano‐scale vesicles involved in intercellular communication and have a significant role cancer progression. Tetraspanins, transmembrane proteins enriched exosomes. These exosome biogenesis, cargo sorting,and target‐cell interactions, influencing tumor development therapeutic response. Exosomal tetraspanins, including CD9, CD63, CD81, Tspan8, contribute to cell proliferation, angiogenesis, extracellular matrix remodelling, immune evasion, promote metastasis. Their ability prepare distant organ sites for colonization highlights their establishing the premetastatic niche. Expression profiling of exosomal tetraspanin become promising diagnostic prognostic biomarker. also be an effective target cancer.This article highlighted impactful ofexosomal Proteins Cancer.
Language: Английский
Citations
6
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 1400 - 1415
Published: Feb. 23, 2024
Exosomes are a subpopulation of extracellular vesicles (EVs) secreted by cells. In cancer, they key cellular messengers during cancer development and progression. Tumor-derived exosomes (TEXs) promote oral the major complication is squamous cell carcinoma (OSCC). show strong participation in several OSCC-related activities such as uncontrolled growth, immune suppression, angiogenesis, metastasis, drug therapeutic resistance. It also potential biomarker source for cancer. Some exosome sources stem cells, plants (it more effective compared to others), engineered reduce development. This approach because its specificity, biocompatibility, cell-free therapy reduced side effects treatment). article highlights exosome-based theranostics signatures clinical trials, challenges research, future improvements. future, may become an affordable solution
Language: Английский
Citations
5
Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(4)
Published: April 1, 2024
Abstract Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease‐specific biomarkers. This feature provides profound insights into the progression of diseases responses patients to treatments. For example, leukemia, exosomes convey critical information through carriage specific proteins nucleic acids. In case human papillomavirus (HPV)‐mediated cervical cancer, are particularly useful noninvasive detection they transport high‐risk HPV DNA biomolecules, which can be indicators disease. Despite their vast potential, there several challenges associated with use medical diagnostics. These include inherent heterogeneity, need enhanced sensitivity methods, establishment standardization protocols, requirement cost‐effective scalability application. Addressing these is effective implementation exosome‐based Future research development geared towards overcoming obstacles. Efforts concentrated on refining processes biomarker discovery, establishing comprehensive regulatory frameworks, developing convenient point‐of‐care devices, exploring methods multimodal detection, conducting extensive clinical trials. The ultimate goal efforts inaugurate new era precision diagnostics within healthcare. would significantly improve patient outcomes reduce burden such leukemia HPV‐mediated cancer. integration cutting‐edge technology holds promise reinforcing foundations healthcare, leading diagnostic accuracy, better disease monitoring, more personalized therapeutic approaches.
Language: Английский
Citations
5