Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(1)
Published: Jan. 28, 2024
Abstract The epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing central role the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into complexities EMT, process where cancer cells gain exceptional mobility, facilitating their invasion distant organs and establishment secondary malignancies. We thoroughly examine myriad factors influencing encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions intricate dynamics tumour microenvironment. Particularly, emphasises advanced stages crucial for development highly aggressive phenotypes. During this phase, penetrate vascular barrier exploit bloodstream to propagate life‐threatening metastases through mesenchymal–epithelial transition. also explore EMT's significant fostering dormancy, senescence, emergence stem formidable challenge therapeutic resistance. Our transcends mere inventory EMT‐inducing elements; it critically assesses current state EMT‐focused clinical trials, revealing both hurdles breakthroughs. Highlighting potential EMT research, we project its transformative impact on future therapy. exploration is aimed at paving way towards an era effectively managing relentless disease, positioning forefront innovative research strategies.
Language: Английский
Citations
11Stem Cell-Derived Exosomes: An Advanced Horizon to Cancer Regenerative Medicine
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2128 - 2139
Published: April 3, 2024
Cancer research has made significant progress in recent years, and extracellular vesicles (EVs) based cancer investigation reveals several facts about cancer. Exosomes are a subpopulation of EVs. In the present decade, exosomes is mostly highlighted for theranostic research. Tumor cell derived (TEXs) promote but there multiple sources that can be used as therapeutic agents (plant exosomes, stem cell-derived modified or synthetic exosomes). Stem cells regenerative medicine faces numerous challenges, such tumor development, cellular reprogramming etc., therefore addressing these complications becomes essential. serves an answer to problems offers better solution. Global indicates also play dual role system by either inhibiting promoting Modified which genetically engineered surface increase efficacy properties considered target above concerns. However, difficulties associated with include variations heterogenity, isolation protocols, large scale production, have managed effectively. this review, we explore biogenesis, exosome sources, drug delivery, clinical trial related challenges domain future orientation. This article may encourage researchers develop effective affordable
Language: Английский
Citations
11Landscape of exosomes to modified exosomes: a state of the art in cancer therapy
RSC Advances, Journal Year: 2024, Volume and Issue: 14(42), P. 30807 - 30829
Published: Jan. 1, 2024
Modified exosomes are a smart tool for the upcoming precision cancer therapeutic era.
Language: Английский
Citations
9Clinical Impact of Exosome Chemistry in Cancer
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.
Language: Английский
Citations
1Role of Exosomes in Epithelial–Mesenchymal Transition
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 7(1), P. 44 - 58
Published: Dec. 18, 2023
Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into motile population that migrates to distant organs and forms secondary tumors. In recent years, research has revealed strong connection between exosomes the EMT. Exosomes, subpopulation of extracellular vesicles, facilitate cellular communication dynamically regulate various aspects including immune cell suppression, matrix remodeling, metastasis initiation, EMT organ-specific metastasis. Tumor-derived (TEXs) their molecular cargo, comprising proteins, lipids, nucleic acids, carbohydrates, are essential components promote in cancer. TEXs miRNAs play crucial role reprogramming tumor microenvironment, while TEX surface integrins contribute Exosome-based offers deeper understanding about an effective theranostic platform development. Additionally, therapeutic sources paving way for innovative treatment this Review, we spotlight impact, aiming inspire researchers worldwide explore fascinating field more ways.
Language: Английский
Citations
21Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis
ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(9), P. 5205 - 5221
Published: Aug. 14, 2023
Glioblastoma (GBM) is an aggressive type of cancer that has led to the death a large population. The traditional approach fails develop solution for GBM's suffering life. Extensive research into tumor microenvironments (TME) indicates TME extracellular vesicles (EVs) play vital role in development and progression. EVs are classified microvacuoles, apoptotic bodies, exosomes. Exosomes most highlighted domains research. GBM cell-derived exosomes participate multiple progression events such as immune suppression, angiogenesis, premetastatic niche formation (PMN), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), metastasis, stem cell therapeutic drug resistance. also carry signature glioblastoma-related status. exosome-based examination part new generation liquid biopsy. It solved early diagnostic limitations GBM. Traditional approaches do not cross blood–brain barrier (BBB). game changer treatment it emerging potential platform effective, efficient, specific development. In this review, we have explored exosome–GBM interlink, clinical impact on biomarkers, therapeutics GBM, challenges, future directions Therefore, GBM-derived offer unique opportunities, which currently under preclinical testing.
Language: Английский
Citations
16Exosomal miRNAs and breast cancer: a complex theranostics interlink with clinical significance
Biomarkers, Journal Year: 2023, Volume and Issue: 28(6), P. 502 - 518
Published: June 24, 2023
Breast cancer (BC) remains the most challenging global health crisis of current decade, impacting a large population females annually. In field research, discovery extracellular vesicles (EVs), specifically exosomes (a subpopulation EVs), has marked significant milestone. general, are released from all active cells but tumour cell-derived (TDXs) have great impact (TDXs miRNAs, proteins, lipid molecules) on development and progression. TDXs regulate multiple events in breast such as microenvironment remodelling, immune cell suppression, angiogenesis, metastasis (EMT-epithelial mesenchymal transition, organ-specific metastasis), therapeutic resistance. BC, early detection is event, exosome-based BC screening solved problem. Exosome-based treatment sign transforming era liquid biopsy, it also promising tool for cancer. Exosome research goes to closer precision oncology via single exosome profiling approach. Our hope that this review will serve motivation researchers explore develop an efficient, affordable theranostics approach
Language: Английский
Citations
15Unlocking Exosome-Based Theragnostic Signatures: Deciphering Secrets of Ovarian Cancer Metastasis
ACS Omega, Journal Year: 2023, Volume and Issue: 8(40), P. 36614 - 36627
Published: Oct. 1, 2023
Ovarian cancer (OC) is a common gynecological worldwide. Unfortunately, the lack of early detection methods translates into substantial cohort women grappling with pressing health crisis. The discovery extracellular vesicles (EVs) (their major subpopulation exosomes, microvesicles, and apoptotic bodies) has provided new insights understanding cancer. Exosomes, EVs, play crucial role in cellular communication reflect status under both healthy pathological conditions. Tumor-derived exosomes (TEXs) dynamically influence ovarian progression by regulating uncontrolled cell growth, immune suppression, angiogenesis, metastasis, development drug therapeutic resistance. In field OC diagnostics, TEXs offer potential biomarkers various body fluids. On other hand, have also shown promising abilities to cure this review, we address interlink between explore their theragnostic signature. Finally, highlight future directions exosome-based research.
Language: Английский
Citations
14Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 1400 - 1415
Published: Feb. 23, 2024
Exosomes are a subpopulation of extracellular vesicles (EVs) secreted by cells. In cancer, they key cellular messengers during cancer development and progression. Tumor-derived exosomes (TEXs) promote oral the major complication is squamous cell carcinoma (OSCC). show strong participation in several OSCC-related activities such as uncontrolled growth, immune suppression, angiogenesis, metastasis, drug therapeutic resistance. It also potential biomarker source for cancer. Some exosome sources stem cells, plants (it more effective compared to others), engineered reduce development. This approach because its specificity, biocompatibility, cell-free therapy reduced side effects treatment). article highlights exosome-based theranostics signatures clinical trials, challenges research, future improvements. future, may become an affordable solution
Language: Английский
Citations
5Exosome-mediated CRISPR/Cas delivery: A cutting-edge frontier in cancer gene therapy
Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149296 - 149296
Published: Jan. 1, 2025
Language: Английский
Citations
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