Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 129 - 156

Published: Nov. 10, 2023

Maxillofacial bone defects caused by congenital malformations, trauma, tumors, and inflammation can severely affect functions aesthetics of maxillofacial region. Despite certain successful clinical applications biomaterial scaffolds, ideal regeneration remains a challenge in region due to its irregular shape, complex structure, unique biological functions. Scaffolds that address multiple needs are under development optimize capacity, costs, operational convenience. etc. In this review, we first highlight the special considerations provide an overview scaffolds for examination their efficacy, which basis directions future scaffold design. Latest advances these then discussed, as well perspectives challenges. Deepening our understanding will help foster better innovations improve outcome tissue engineering.

Language: Английский

---

Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

International Journal of Implant Dentistry, Journal Year: 2021, Volume and Issue: 7(1)

Published: Dec. 1, 2021

To address the focused question: in patients with freshly extracted teeth, what is efficacy of platelet-rich fibrin (PRF) prevention pain and regeneration soft tissue bone compared to respective control without PRF treatment?After an electronic data search PubMed database, Web Knowledge Thomson Reuters hand relevant journals, a total 20 randomized and/or controlled studies were included.66.6% showed that significantly reduced postoperative pain, especially first 1-3 days after tooth extraction. Soft healing was improved group spontaneous wound 1 week (75% evaluated studies). Dimensional loss lower 8-15 weeks but not 6 months. Socket fill 85% higher healing.Based on analyzed studies, most effective early period 2-3 months A longer may provide any benefits. The currently available do allow statement regarding long-term implant success sockets treated or its combination biomaterials. Due heterogeneity no meta-analysis performed.

Language: Английский

---

Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 16, 2024

Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of fibrin scaffold and its internal loading growth factors, platelets, leukocytes, with the gradual degradation slow release physiological doses factors. PRF promotes vascular regeneration, proliferation migration osteoblast-related cells such as mesenchymal cells, osteoblasts, osteoclasts while having certain immunomodulatory anti-bacterial effects. has excellent osteogenic potential been widely used in field bone tissue engineering dentistry. However, there are still some limitations PRF, improvement biological properties is one most important issues to be solved. Therefore, it often combined scaffolds enhance mechanical delay degradation. In this paper, we present systematic review development platelet-rich derivatives, structure mechanisms, applications, optimization broaden their clinical applications provide guidance for translation.

Language: Английский

---

Introduction of a Semi-Quantitative Image-Based Analysis Tool for CBCT-Based Evaluation of Bone Regeneration in Tooth Extraction Sockets

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 301 - 301

Published: March 16, 2025

After tooth extraction, resorptive changes in extraction sockets and the adjacent alveolar ridge can affect subsequent replacement implantation. Several surgical concepts, including application of autologous blood concentrate platelet-rich fibrin (PRF), aim to reduce these changes. While PRF’s wound-healing pain-relieving effects are well-documented, its impact on bone regeneration is less clear due varying PRF protocols measurement methods for regeneration. This study aimed develop a precise, easy-to-use non-invasive radiological evaluation method that examines entire socket assess using CBCT data from clinical trials. The method, based freely available Image J-based software “Fiji”, proved be reproducible, transferable. As limitation remains time requirement exclusive focus Nevertheless, presented here more precise than ones currently described literature, as it evaluates rather partial areas. novel measure mineralized volume density newly formed randomized, controlled trial assessing solid preservation premolar molar showed only slight, statistically non-significant trends toward better group compared natural healing.

Language: Английский

---

Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Journal of Periodontology, Journal Year: 2022, Volume and Issue: 93(12), P. 1827 - 1847

Published: July 16, 2022

Abstract Background The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), implant site development (ISD). present systematic review aimed to analyze the effect autologous blood‐derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB), bone morphogenetic protein‐2 (rhBMP‐2), on outcomes ARP/ARR ISD therapy (i.e., augmentation [ARA] maxillary sinus floor [MSFA]). Methods An electronic search eligible articles published from January 2000 October 2021 was conducted. Randomized clinical trials evaluating efficacy ABPs, EMD, rhBMP‐2, rhPDGF‐BB were included according pre‐established eligibility criteria. Data linear volumetric dimensional changes, histomorphometric findings, a variety secondary clinical, implant‐related, digital imaging, safety, patient‐reported outcome measures [PROMs]) extracted critically analyzed. Risk bias assessment selected investigations also Results A total 39 analyzed qualitatively. Due high level heterogeneity across studies, quantitative analyses not feasible. Most studies in topic revealed that rendered similar results compared with conventional protocols. However, when juxtaposed unassisted healing or socket filling using collagen sponges, application did contribute attenuate post‐extraction atrophy most investigations. Additionally, positively influenced by biologics. ARA interventions yield superior radiographic control therapies. Nevertheless, ABPs enhanced new formation reduced likelihood early wound dehiscence. MSFA translate into outcomes. It observed, though, some promote during earlier stages healing. Only four evaluated PROMs reported modest beneficial impact pain swelling. No severe adverse events association this noted. Conclusions Outcomes after edentulous ridges comparable among different therapeutic modalities review. PRF, rhPDGF‐BB, rhBMP‐2) combination graft material generally faster groups.

Language: Английский

---

Growth Factor Release within Liquid and Solid PRF

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(17), P. 5070 - 5070

Published: Aug. 29, 2022

Aim: The purpose of this study was to obtain data concerning growth factor release within liquid and solid platelet-rich fibrin (PRF) matrices estimate the amount potential interindividual variations as a basis for further preclinical clinical trials. Therefore, we aimed determine possible differences in factors between PRF. Materials Methods: Blood samples obtained from four subjects were processed both PRF using standard centrifugation protocol. Five (vascular endothelial factor, VEGF; epidermal EGF; platelet-derived factor-BB, PDGF-BB; transforming factor-β1, TGF-β1; matrix metallopeptidase 9, MMP-9) have been evaluated at six time points by ELISA over total observation period 10 days (1 h, 7 1 d, 2 d). Results: Growth could be measured all each point. Comparing matrices, no significant detected (p > 0.05). mean VEGF, TGFβ-1, PDGF-BB, MMP-9 raised peak point five (day 7) matrices. VEGF lower than PRF, whereas those PDGF-BB higher points. EGF had its already two after h (hour solid: = 180 pg/mL, SD 81; liquid: 218 64), declined rapidly until day 2, second slight on groups 182 189; 81 70). Conclusions: This with little variations. Further trials are needed precisely analyze larger better understand their effects wound healing different indications.

Language: Английский

---

Platelet-Rich Fibrin Decreases the Inflammatory Response of Mesenchymal Cells

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11333 - 11333

Published: Oct. 20, 2021

Chronic inflammation is a pathological process where cells of the mesenchymal lineage become major source inflammatory mediators. Platelet-rich fibrin (PRF) has been shown to possess potent anti-inflammatory activity in macrophages, but its impact on not investigated. The aim this study was, therefore, expose cytokines together with lysates generated from liquid platelet-poor plasma (PPP), cell-rich buffy coat layer (BC; concentrated-PRF or C-PRF), and remaining red clot (RC), following centrifugation blood. Heating PPP generates an albumin gel (Alb-gel) that when mixed back C-PRF produces Alb-PRF. Membranes prepared solid PRF were also subjected lysis. We report here PPP, BC, decreased cytokine-induced expression interleukin 6 (IL6) nitric oxide synthase (iNOS) bone marrow-derived ST2 cells. Consistently, greatly phosphorylation nuclear translocation p65 response caused by Pam3CSK4 was reduced accordingly. Moreover, enhanced mediators IL6 iNOS 3T3-L1 pre-adipocyte cells, CCL5 murine calvarial Surprisingly, effective reducing human gingival fibroblasts HSC2 epithelial data present suggest both exert

Language: Английский

---

Effect of the use of platelet concentrates on new bone formation in alveolar ridge preservation: a systematic review, meta-analysis, and trial sequential analysis

Clinical Oral Investigations, Journal Year: 2023, Volume and Issue: 27(8), P. 4131 - 4146

Published: July 13, 2023

Abstract Objectives To investigate the histomorphometric changes occurring in alveolar ridge preservation (ARP) based on use of different plasma concentrates (PCs) randomized clinical trials (RCT). There is controversy whether placement PCs ARP effective formation new bone. Materials and methods A systematic review search was conducted PubMed, Scopus, Web Science, Cochrane Database to answer PICO question: In patients undergoing tooth extraction followed by ARP, do alone post-extraction socket comparison with spontaneous healing improve vital bone percentage analysis after more than 10 weeks? The risk bias assessed a meta-analysis conducted. Results Of 3809 results, 8 studies were considered suitable for inclusion. total 255 teeth extracted 250 patients. Regarding used, performed platelet- leukocyte-rich fibrin (L-PRF) 120 sockets, pure platelet-rich (P-PRP) 31 sockets 104 controlled. improved respect group (SMD = 1.77, 95%C.I. 1.47–2.06, p -value < 000.1). no differences between (L-PRF P-PRP). Conclusion results this support efficacy ARP. With types studied, observed. Clinical relevance When planning implant surgery extraction, treatment should be Any PC increases compared healing.

Language: Английский

---

Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta‐analyses

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract In order to evaluate the therapeutic advantages of various autologous platelet concentrates (APC) as a single biomaterial during alveolar ridge preservation (ARP), systematic review with meta‐analyses was conducted. PubMed, EMBASE, Web Science, and Scopus were screened for randomized controlled trials (RCTs) that released prior 2024. The selected papers compared an APC either unassisted healing (blood clot) or another ARP (third molars not included). outcome parameters included bone dimension alterations, soft tissue healing, post‐op pain intensity. search yielded 35 (33 studies), one applying platelet‐rich plasma (PRP), six using rich in growth factors (PRGF), 28 leukocyte‐ fibrin (L‐PRF). These studies showed large heterogeneity (e.g., parameters, timing, surgical approach, inclusion criteria), which hindered drawing strong conclusions. most studies, however, PRP, PRGF, L‐PRF alone produced faster less post‐extraction pain, resorption, more socket fill, higher density when (spontaneous) healing. ultimate benefit appears be significantly influenced by approach. Limited literature exists comparing other biomaterials ARP, resulting inconclusive data. application is promising strategy improve hard reduce pain.

Language: Английский

---

Efficacy of the application of leukocyte and platelet‐rich fibrin (L‐PRF) on alveolar ridge preservation. A randomized controlled clinical trial

Clinical Implant Dentistry and Related Research, Journal Year: 2023, Volume and Issue: 25(3), P. 592 - 604

Published: April 23, 2023

Abstract Introduction Alveolar ridge preservation (ARP) is a well‐defined treatment performed to reduce bone dimensional changes occurring during the healing of post‐extraction sockets allow for adequate implant placement. Leukocyte and platelet‐rich fibrin (L‐PRF) has been showing potentially promote tissue regeneration wound healing. Therefore, aim this study evaluate its efficacy ARP when applied fresh extraction sockets, in comparison with spontaneous Materials Methods Twenty‐seven patients hopeless non‐molar teeth were treated. After randomization, either filled L‐PRF or allowed heal spontaneously. CBCTs intraoral scans obtained immediately after at 4 months. Through superimposition images, horizontal width, height, buccal volume, contour measured, as well patient‐reported outcome measures (PROM's). Results The dimensions changed similarly both groups. Although less reduction occurred test group 1 mm from crest, differences not statistically significant ( p > 0.05). Application did prevent reductions contours, neither linear vertical aspect nor volumetric changes. There no between groups need placing implants. Patients reported similar outcomes terms bleeding, pain, inflammation, function weeks postoperatively. Conclusion minimized resorption tooth sites reduced Furthermore, use improve PROM's.

Language: Английский

---