Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe)

Journal Of Clinical Periodontology, Journal Year: 2023, Volume and Issue: 50(6), P. 819 - 841

Published: March 20, 2023

Abstract Aim To explore the implications for dentists and family doctors of association between periodontal systemic diseases role in managing non‐communicable (NCDs) promoting healthy lifestyles. Materials Methods The consensus reports previous Focused Workshops on associations periodontitis diabetes (2017) cardiovascular (2019) formed technical reviews to underpin discussions both topics. For with respiratory diseases, a systematic review was specifically commissioned Workshop discussions. Working groups prepared proposals independently, then were discussed approved at plenary meetings. Results Periodontitis is independently associated diabetes, chronic obstructive pulmonary disease (COPD), sleep apnea COVID‐19 complications. Dentists should collaborate NCDs, implementing strategies early detection primary care centres or dental settings. Family be informed about their consequences, oral health professionals (OHPs) relevance NCDs risk factors. Conclusions Closer collaboration OHPs important management Pathways case medicine practices developed evaluated.

Language: Английский

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Periodontal diseases and cardiovascular diseases, diabetes, and respiratory diseases: Summary of the consensus report by the European Federation of Periodontology and WONCA Europe

European Journal of General Practice, Journal Year: 2024, Volume and Issue: 30(1)

Published: March 21, 2024

Periodontitis is a chronic inflammatory non-communicable disease (NCD) characterised by the destruction of tooth-supporting apparatus (periodontium), including alveolar bone, presence periodontal pockets, and bleeding on probing.

Language: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

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Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Periodontitis: An often-neglected complication of diabetes

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 15(3), P. 318 - 325

Published: March 15, 2024

The bidirectional association between type 2 diabetes mellitus (T2DM) and periodontitis is now well established, resulting in periodontal disease being considered as the 6th major complication of (DM) after car-diovascular disease, eye neuropathy, nephropathy, peripheral vascular disease. DM can worsen virulence invasiveness pathogenic oral microbial flora aggravating local inflammation infection those with On other hand, chemical immunological mediators released into circulation part systemic insulin resistance worsening T2DM. Periodontitis if undiagnosed or left untreated also result eventual tooth loss. A study by Xu et al World Journal Diabetes examined predictive factors associated Chinese patients prevalence was found to be 75.7% this study. Based on logistic regression analysis, for higher risk were low brushing frequency [odds ratio (OR) = 4.3], high triglycerides (TG; OR 3.31), total cholesterol (TC; 2.87), glycated hemoglobin (HbA1c; 2.55), age (OR 1.05) while education level protective 0.53). However, most influential variables HbA1c followed age, TC, TG, level, frequency, sex random forest model (this showed sensitivity predicting risk). good understanding predictors T2DM important prevention, early detection susceptible patients, intervention improve health enable long-term glycaemic control observed .

Language: Английский

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Unveiling the Resistome Landscape in Peri-Implant Health and Disease

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 931 - 931

Published: Jan. 31, 2025

Background: The human oral microbiome is a critical reservoir for antibiotic resistance; however, subgingival peri-implant biofilms remain underexplored in this context. We aimed to explore the prevalence and distribution of resistance genes (ARGs) metagenomes derived from saliva biofilms. Methods: A total 100 metagenome datasets 40 individuals were retrieved Sequence Read Archive (SRA) database. Of these, 20 had exclusively healthy implants both affected with peri-implantitis. ARGs their taxonomic assignments identified using ABRicate tool, plasmid detection was performed PlasmidFinder. Results: Four replicons 72 metagenomes, 55 distinct 13 classes detected 89 metagenomes. conferring macrolides-lincosamides-streptogramins, tetracyclines, beta-lactams, fluoroquinolones most prevalent. msr(D) mef(A) showed highest prevalence, except samples implants, where ranked fourth. pairwise PERMANOVA principal coordinate analysis based on Jaccard distances revealed that exhibited significantly greater ARG diversity than biofilm (p < 0.05). However, no significant differences observed between peri-implantitis-affected groups > origins also analyzed understand potential impact microbial communities. Conclusions: Resistome profiles associated health disease higher salivary abundance compared samples.

Language: Английский

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Periodontal Treatment to Improve General Health and Manage Systemic Diseases

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 245 - 260

Published: Jan. 1, 2025

Language: Английский

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The relationship between periodontal disease and cancer: Insights from a Systematic Literature Network Analysis

Cancer Epidemiology, Journal Year: 2024, Volume and Issue: 91, P. 102595 - 102595

Published: June 14, 2024

Language: Английский

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Associations between different triglyceride glucose index-related obesity indices and periodontitis: results from NHANES 2009–2014

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 5, 2024

Abstract Background This study aimed to explore the associations between triglyceride glucose (TyG) index-related obesity indices and periodontitis within American population. Methods cross-sectional investigation utilized data from National Health Nutrition Examination Survey (NHANES) for 2009–2014. The association TyG–waist-to-height ratio (TyG-WHtR), TyG–weight-adjusted-waist index (TyG-WWI), TyG–waist circumference (TyG-WC), or TyG–body mass (TyG-BMI) was investigated utilizing multivariable logistic regression model, subgroup, dose-response curve analyses. Results enrolled 4,808 adult participants. Except TyG-BMI, which did not exhibit a relationship with periodontitis, TyG-WHtR, [odds (OR) (95% confidence interval (CI))] = 2.83 [1.58–5.10], P 0.002], TyG-WWI [OR CI) 7.50 (3.06–18.34), < 0.001], TyG-WC 2.12 (1.23–3.64), 0.011] were all associated periodontitis. Participants in highest quartile displayed an elevated risk of relative their counterparts lowest quartile, as evidenced 1.72 (1.26–2.33), 0.001] 1.50 (1.13–1.99), 0.009] full adjustment model. Subgroup analyses suggested more pronounced positive these participants who 60 years old, had BMI ≥ 25, have diabetes. indicated linear responses associations. Conclusions identified significant stable TyG-WWI, implies robust correlation high insulin resistance susceptibility

Language: Английский

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Periodontal Disease and Obstructive Sleep Apnea: Shared Mechanisms, Clinical Implications, and Future Research Directions

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 542 - 542

Published: Jan. 8, 2025

This review explores the emerging relationship between obstructive sleep apnea (OSA) and periodontal disease (PD), emphasizing shared inflammatory pathways, overlapping risk factors, potential systemic health implications. Both conditions are characterized by chronic inflammation oxidative stress, which independently contribute to cardiovascular disease, diabetes, other disorders. Evidence suggests a bidirectional relationship, with OSA-related hypoxia exacerbating tissue breakdown PD-induced potentially influencing OSA severity. However, causative nature of PD remains uncertain, largely due inconsistencies in diagnostic criteria, methodological variability, study heterogeneity. highlights essential role systematic reviews (SRs) synthesizing current evidence, identifying research gaps, guiding future studies. To maximize their impact, SRs should adhere rigorous quality standards, improve transparency data reporting, address heterogeneity included Future focus on longitudinal interventional designs, standardize protocols, investigate biomarkers, oral microbiome profiles, mediators elucidate mechanisms linking PD. Multidisciplinary collaboration dental specialists is crucial advancing evidence-based strategies that patient outcomes broader implications these often coexisting conditions.

Language: Английский

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