Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities DOI Creative Commons
Charlotte A. M. Cecil, Alexander Neumann, Esther Walton

et al.

JCPP Advances, Journal Year: 2022, Volume and Issue: 3(1)

Published: Dec. 23, 2022

Epigenetic processes are fast emerging as a promising molecular system in the search for both biomarkers and mechanisms underlying human health disease risk, including psychopathology.In this review, we discuss application of epigenetics (specifically DNA methylation) to research child adolescent mental health, with focus on use developmentally sensitive datasets, such prospective, population-based cohorts. We look back at lessons learned date, highlight current developments field areas priority future research. also reflect why epigenetic currently lags behind other what can do overcome existing barriers.To move forward, advocate need large-scale, harmonized, collaborative efforts that explicitly account time-varying nature data across development.We conclude perspective may hold terms translational applications more robust signals emerge from health.

Language: Английский

Attention-deficit hyperactivity disorder DOI
Jonathan Posner, Guilherme V. Polanczyk, Edmund Sonuga‐Barke

et al.

The Lancet, Journal Year: 2020, Volume and Issue: 395(10222), P. 450 - 462

Published: Jan. 23, 2020

Language: Английский

Citations

607
Diet and depression: exploring the biological mechanisms of action DOI
Wolfgang Marx, Melissa M. Lane, Meghan Hockey

et al.

Molecular Psychiatry, Journal Year: 2020, Volume and Issue: 26(1), P. 134 - 150

Published: Nov. 3, 2020

Language: Английский

Citations

461
Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study DOI
Erin C. Dunn, Thomas W. Soare, Yiwen Zhu

et al.

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 85(10), P. 838 - 849

Published: Jan. 21, 2019

Language: Английский

Citations

276
Early environmental influences on the development of children's brain structure and function DOI Open Access
Patrícia Maidana Miguel, Lenir Orlandi Pereira, Patrícia Pelufo Silveira

et al.

Developmental Medicine & Child Neurology, Journal Year: 2019, Volume and Issue: 61(10), P. 1127 - 1133

Published: Feb. 11, 2019

The developing brain in utero and during the first years of life is highly vulnerable to environmental influences. Experiences occurring this period permanently modify structure function through epigenetic modifications (alterations DNA chromatin function) consequently affect susceptibility mental disorders. In review, we describe evidence linking adverse variation early (from fetal childhood) long‐term changes volume, microstructure, connectivity, especially amygdala hippocampal regions. We also genetic variations that moderate impact conditions on child neurodevelopment, such as polymorphisms brain‐derived neurotrophic factor catechol‐O‐methyltransferase genes, well pathways related glutamate monoaminergic signaling. Lastly, have depicted positive experiences could benefit childhood neurodevelopment reverse some detrimental effects adversity offspring. What paper adds Prenatal, peripartum, postnatal adversities influence behavior neurodevelopment. Exposure enrichment influences may revert these effects. Putative mechanisms involve alterations factors neurotransmitter systems. New tools/big data improved understanding how alters This permits better translation/application findings from animal models humans.

Language: Английский

Citations

272
The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions DOI
Boadie W. Dunlop,

Andrea W. Wong

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2018, Volume and Issue: 89, P. 361 - 379

Published: Oct. 17, 2018

Language: Английский

Citations

201
Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum DOI
Robert F. Krueger, Kelsey A. Hobbs, Christopher Conway

et al.

World Psychiatry, Journal Year: 2021, Volume and Issue: 20(2), P. 171 - 193

Published: May 18, 2021

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations traditional mental disorder diagnoses. These include arbitrary boundaries between and normality, co‐occurrence in the modal case, heterogeneity presentation within dis­orders, instability diagnosis patients. This paper reviews evidence on validity utility disinhibited externalizing antagonistic spectra HiTOP, which together constitute a broad superspectrum. are composed elements subsumed variety disorders described recent DSM nosologies, including most notably substance use “Cluster B” personality disorders. superspectrum ranges from normative levels impulse control self‐assertion, maladaptive disinhibition antagonism, extensive polysubstance involvement psychopathology. A rich literature supports superspectrum, spectra. encompasses common genetic influences, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, treatment response. structure these validators mirrors phenotypic with some correlates more specific or spectra, others relevant entire underlining hierarchical domain. Compared diagnostic categories, conceptualization shows improved utility, reliability, explanatory capacity, clinical applicability. one aspect general approach psychopathology offered by HiTOP can make classification useful both research clinic.

Language: Английский

Citations

199
Childhood maltreatment and DNA methylation: A systematic review DOI Creative Commons
Charlotte A. M. Cecil, Yuning Zhang, Tobias Nolte

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 112, P. 392 - 409

Published: Feb. 17, 2020

DNA methylation (DNAm) - an epigenetic process that regulates gene expression may represent a mechanism for the biological embedding of early traumatic experiences, including childhood maltreatment. Here, we conducted first systematic review human studies linking maltreatment to DNAm. In total, 72 were included in (2008-2018). The majority extant (i) based on retrospective data adults, (ii) employed candidate approach (iii) focused global maltreatment, (iv) easily accessible peripheral tissues, typically blood; and (v) cross-sectional. Two-thirds (n = 48) also examined maltreatment-related outcomes, such as stress reactivity psychiatric symptoms. While findings generally support association between altered patterns DNAm, factors lack longitudinal data, low comparability across well potential genetic 'pre-exposure' environmental confounding currently limit conclusions can be drawn. Key challenges are discussed concrete recommendations future research provided move field forward.

Language: Английский

Citations

141
Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis DOI Creative Commons
Alexander Neumann, Esther Walton, Silvia Alemany

et al.

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: Nov. 12, 2020

Attention-deficit and hyperactivity disorder (ADHD) is a common childhood with substantial genetic component. However, the extent to which epigenetic mechanisms play role in etiology of unknown. We performed epigenome-wide association studies (EWAS) within Pregnancy And Childhood Epigenetics (PACE) Consortium identify DNA methylation sites associated ADHD symptoms at two assessment periods: birth school age. examined associations both cord blood repeatedly assessed (age 4-15 years) 2477 children from 5 cohorts age concurrent 7-11 2374 9 cohorts, 3 participating timepoints. CpGs identified nominal significance (p < 0.05) either EWAS were correlated between timepoints (ρ = 0.30), suggesting overlap associations; however, top signals very different. At birth, we nine that predicted later 1 × 10-7), including ERC2 CREB5. Peripheral one these (cg01271805 promoter region ERC2, regulates neurotransmitter release) was previously brain methylation. Another (cg25520701) lies gene body CREB5, neurite outgrowth an diagnosis. In contrast, age, no p 10-7. conclusion, found evidence this study ADHD. Future are needed confirm utility variation as biomarker its involvement causal pathways.

Language: Английский

Citations

84
The role of epigenetics in psychological resilience DOI
Demelza Smeeth, Stephan Beck, Elie G. Karam

et al.

The Lancet Psychiatry, Journal Year: 2021, Volume and Issue: 8(7), P. 620 - 629

Published: April 27, 2021

Language: Английский

Citations

64
Mechanisms of neuroplasticity linking early adversity to depression: developmental considerations DOI Creative Commons
Tiffany C. Ho, Lucy S. King

Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)

Published: Oct. 9, 2021

Abstract Early exposure to psychosocial adversity is among the most potent predictors of depression. Because depression commonly emerges prior adulthood, we must consider fundamental principles developmental neuroscience when examining how experiences childhood adversity, including abuse and neglect, can lead Considering that both environment brain are highly dynamic across period spanning gestation through adolescence, purpose this review discuss integrate stress-based models center processes. We offer a general framework for understanding in early life disrupts or calibrates biobehavioral systems implicated Specifically, propose sources nature environmental input shaping brain, mechanisms neuroplasticity involved, change development. contend effects largely depend on stage organism. First, summarize leading neurobiological focus risk mental disorders, In particular, highlight allostatic load, acceleration maturation, dimensions sensitive critical s. Second, expound evidence formulation distinct depending timing adverse experiences, inherent within certain windows development constraints these experiences. Finally, other important facets (e.g., unpredictability, perceptions one’s experiences) before discussing promising research directions future field.

Language: Английский

Citations

62