Human milk microbiome: associations with maternal diet and infant growth DOI Creative Commons

Tamara T. Ajeeb,

Emmanuel González,

Noel W. Solomons

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 11, 2024

Introduction Ingestion of human milk (HM) is identified as a significant factor associated with early infant gut microbial colonization, which has been health and development. Maternal diet the HM microbiome (HMM). However, few studies have explored associations among maternal diet, HMM, growth during first 6 months lactation. Methods For this cross-sectional study, Mam -Mayan mother-infant dyads ( n = 64) were recruited from 8 rural communities in Western Highlands Guatemala at two stages lactation: (6–46 days postpartum, 29) or late (109–184 35). Recruited mothers had vaginally delivered singleton births, no subclinical mastitis antibiotic treatments, breastfed their infants. Data collected both lactation included 24-h recalls, samples, status indicators: head-circumference-for-age-z-score (HCAZ), length-for-age-z-score (LAZ), weight-for-age-z-score (WAZ). Infants divided into subgroups: normal weight (WAZ ≥ −1SD) mildly underweight < −1SD), non-stunted (LAZ −1.5SD) stunted −1.5SD), head-circumference (HCAZ smaller −1SD). HMM was using 16S rRNA gene sequencing; amplicon analysis performed high-resolution ANCHOR pipeline, DESeq2 differentially abundant (DA) species-level between groups (FDR 0.05) Results Using cluster univariate analyses, we (a) positive correlations clusters dietary clusters, (b) negative macronutrient micronutrient intakes species level (c) distinct DA taxa nutrient z-scores that differed breast-fed infants experiencing faltering Conclusion Collectively, these findings provide important evidence potential influence on early-life via modulation HMM.

Language: Английский

The Influence of Dietary Factors on the Gut Microbiota DOI Creative Commons
Esther Nova, Sonia Gómez‐Martínez, Rocío González-Soltero

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1368 - 1368

Published: July 7, 2022

There is increasing evidence that diet influences the relationship between gut microbiota and individual health outcomes. Nutrient intake affects composition of microbial community provides metabolites influence host physiology. Dietary patterns, including macronutrient balance feeding/fasting cycles which may be manipulated with dietary regimens based on caloric restriction periods, homeostasis through its impact ecosystem. Along same line, prebiotic probiotic ingredients additives in foods, as well degree food processing have consequences related immune metabolic response human host. Acquiring knowledge these aspects, especially an -omics-integral approach, might provide basis for personalized nutritional interventions directed to avoid dysbiosis contribute prevention major chronic degenerative diseases. Despite vast scientific supporting factors function, underlying mechanisms their potential are far from clear. a lack well-designed longitudinal studies performed target population groups whose patterns can particularly relevant future health, case infants, pregnant women, or athletes.

Language: Английский

Citations

77
Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis DOI

Elizabeth Schneider,

Kenneth J. O’Riordan, Gerard Clarke

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(8), P. 1454 - 1478

Published: Aug. 22, 2024

Language: Английский

Citations

33
Neutrophils Actively Contribute to Obesity-Associated Inflammation and Pathological Complications DOI Creative Commons
Eileen Uribe‐Querol, Carlos Rosales

Cells, Journal Year: 2022, Volume and Issue: 11(12), P. 1883 - 1883

Published: June 10, 2022

Obesity is characterized by an increase in body weight associated with exaggerated enlargement of the adipose tissue. has serious negative effects because it multiple pathological complications such as type 2 diabetes mellitus, cardiovascular diseases, cancer, and COVID-19. Nowadays, 39% world population obese or overweight, making obesity 21st century epidemic. also a mild, chronic, systemic inflammation. Accumulation fat tissue causes stress malfunction adipocytes, which then initiate Next, infiltrated cells innate immune system. Recently, become evident that neutrophils, most abundant leukocytes blood, are first infiltrating Neutrophils get activated release inflammatory factors recruit macrophages other cells. These cells, turn, perpetuate inflammation state producing cytokines chemokines can reach parts body, creating condition. In this review, we described recent findings on role neutrophils during initiation addition, discuss involvement generation obesity-related using prime example.

Language: Английский

Citations

61
Dietary Polysaccharides as Modulators of the Gut Microbiota Ecosystem: An Update on Their Impact on Health DOI Open Access
Ana I. Álvarez‐Mercado, Julio Plaza‐Díaz

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 4116 - 4116

Published: Oct. 3, 2022

A polysaccharide is a macromolecule composed of more than ten monosaccharides with wide distribution and high structural diversity complexity in nature. Certain polysaccharides are immunomodulators play key roles the regulation immune responses during progression some diseases. In addition to stimulating growth certain intestinal bacteria, may also promote health benefits by modulating gut microbiota. last years, studies about triad microbiota–polysaccharides–health have increased exponentially. consequence, present review, we aim summarize recent knowledge function dietary on microbiota composition how these effects affect host health.

Language: Английский

Citations

40
Gut microbiota dysbiosis -associated obesity and its involvement in cardiovascular diseases and type 2 diabetes. A systematic review DOI
Nadia Hamjane, Mohcine Bennani Mechita,

Naima Ghailani Nourouti

et al.

Microvascular Research, Journal Year: 2023, Volume and Issue: 151, P. 104601 - 104601

Published: Sept. 9, 2023

Language: Английский

Citations

26
Alterations in gut microbiome and metabolite profiling during in vitro fermentation of duckweed (Wolffia globosa) and its extracts by gut bacteria from obese adults DOI Creative Commons

Sirajit Dhamaratana,

Pawadee Methacanon, Paiboon Tunsagool

et al.

Future Foods, Journal Year: 2025, Volume and Issue: unknown, P. 100608 - 100608

Published: March 1, 2025

Language: Английский

Citations

1
Polysaccharides influence human health via microbiota-dependent and -independent pathways DOI Creative Commons

Liping Gan,

JinRong Wang, Yuming Guo

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 9, 2022

Polysaccharides are the most diverse molecules and can be extracted from abundant edible materials. Increasing research has been conducted to clarify structure composition of polysaccharides obtained different materials their effects on human health. Humans only directly assimilate very limited polysaccharides, which conveyed distal gut fermented by intestinal microbiota. Therefore, main mechanism underlying bioactive health involves interaction between Recently, interest in role health, obesity, related disorders increased due wide range valuable biological activities polysaccharides. The known roles include mechanisms that microbiota-dependent involve microbiota-derived metabolites microbiota-independent. In this review, we discuss metabolic diseases mechanisms. findings review provide information functional facilitate dietary recommendations for people with issues. To uncover more clinical trials should confirm therapeutic disease. Greater attention directed toward polysaccharide extraction by-products or derived food processing unsuitable direct consumption, rather than extracting them advanced understanding mutualistic microbes, microbiota-fermenting subsequent outcomes insight into proper application improving

Language: Английский

Citations

30
Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease DOI Open Access
Curtis L. Gabriel, Jane F. Ferguson

Circulation Research, Journal Year: 2023, Volume and Issue: 132(12), P. 1674 - 1691

Published: June 8, 2023

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction underlies the leading causes of morbidity mortality, both within United States worldwide. Commensal microbiota are implicated in development cardiometabolic disease. Evidence suggests that microbiome is relatively variable during infancy early childhood, becoming more fixed later childhood adulthood. Effects microbiota, development, life, may induce changes host metabolism modulate risk mechanisms predispose toward In this review, we summarize factors influence gut composition function life explore how microbial throughout life. We highlight limitations current methodology approaches outline state-of-the-art advances, which improving research building refined diagnosis treatment options microbiome-targeted therapies.

Language: Английский

Citations

21
Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome DOI Open Access
Rocío Redondo‐Castillejo, Alba Garcimartín, Marina Hernández-Martín

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5369 - 5369

Published: March 10, 2023

The metabolic syndrome (MS) is a cluster of risk factors, such as central obesity, hyperglycemia, dyslipidemia, and arterial hypertension, which increase the probability causing premature mortality. consumption high-fat diets (HFD), normally referred to high-saturated fat diets, major driver rising incidence MS. In fact, altered interplay between HFD, microbiome, intestinal barrier being considered possible origin Consumption proanthocyanidins (PAs) has beneficial effect against disturbances in However, there are no conclusive results literature about efficacy PAs improving This review allows comprehensive validation diverse effects on dysfunction HFD-induced MS, differentiating preventive therapeutic actions. Special emphasis placed impact gut microbiota, providing system facilitate comparison studies. can modulate microbiome toward healthy profile strength integrity. Nevertheless, date, published clinical trials verify preclinical findings scarce. Finally, MS-associated dysbiosis induced by HFD seems more successful than treatment strategy.

Language: Английский

Citations

17
Role of the Intestine and Its Gut Microbiota in Metabolic Syndrome and Obesity DOI
Celine B.E. Busch, Jacques Bergman, Max Nieuwdorp

et al.

The American Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 119(6), P. 1038 - 1046

Published: Feb. 19, 2024

The metabolic syndrome (MetSyn) is currently one of the biggest global health challenges because its impact on public health. MetSyn includes cluster disorders including obesity, high blood pressure, hyperglycemia, triglyceride levels, and hepatic steatosis. Together, these abnormalities increase cardiovascular risk individuals pose a threat to healthcare systems worldwide. To better understand address this complex issue, recent research has been increasingly focusing unraveling delicate interplay between intestines more specifically our gut microbiome. microbiome entails all microorganisms inhabiting gastrointestinal tract plays pivotal role in processes overall host. Emerging evidence proves an association composition aspects MetSyn, such as obesity. Understanding relationships crucial they offer valuable insights into mechanisms underlying development progression possible treatment options. Yet, how should we interpret relationship? This review focuses MetSyn. In addition, have reviewed existing with disorders, attempt interactions nature association. We also explored potential therapeutic options targeting modify

Language: Английский

Citations

6