Informing the Cannabis Conjecture: From Life’s Beginnings to Mitochondria, Membranes and the Electrome—A Review DOI Open Access
Alistair V.W. Nunn,

Geoffrey W. Guy,

Jimmy D. Bell

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13070 - 13070

Published: Aug. 22, 2023

Before the late 1980s, ideas around how lipophilic phytocannabinoids might be working involved membranes and bioenergetics as these disciplines were “in vogue”. However, interest in genetics pharmacology grew, mitochondria (and membranes) waned. The discovery of cognate receptor for tetrahydrocannabinol (THC) led to classification endocannabinoid system (ECS) conjecture that “working” through this system. “why” they beneficial, especially compounds like CBD, remains unclear. Given centrality complex organisms, their evolutionary heritage from beginnings life, revisiting phytocannabinoid action light could enlightening. For example, life can described a self-organising replicating far equilibrium dissipating system, which is defined by movement charge across membrane. Hence building evidence, at least animals, THC CBD modulate mitochondrial function highly informative. In paper, we offer unique perspective question, why do potentially work medicines so many different conditions? answer, suggest, membrane fluidity number ways thus dissipation engender homeostasis, particularly under stress. To understand this, need embrace origins theories, role plants explanations disease ageing an adaptive thermodynamic perspective, well quantum mechanics.

Language: Английский

Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer’s Disease DOI Creative Commons
Kamila Gabrieli Dallabrida, Jeane Maria de Oliveira,

Ellen Schavarski Chade

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 592 - 592

Published: June 10, 2024

The endocannabinoid system has been linked to various physiological and pathological processes, because it plays a neuromodulator role in the central nervous system. In this sense, cannabinoids have used off-label for neurodevelopmental disorders, such as autism spectrum disorder (ASD) attention-deficit/hyperactivity (ADHA), well Alzheimer's disease (AD), more prevalent neurodegenerative disease. Thus, study aims, through comprehensive literature review, arrive at better understanding of impact therapeutic treatment patients with ASD, ADHD, (AD). Overall, cannabis products rich CBD displayed higher potential ASD children, while THC tested AD therapy. For clinical studies are incipient inconclusive, but promising. general, main limitations lack standardization cannabis-based consumed by participants, scientific rigor, small number participants.

Language: Английский

Citations

6
Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial DOI Open Access

N.G. Kim,

Brenda Parolin,

Derek Renshaw

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 489 - 489

Published: Feb. 8, 2024

Background: Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator which naturally produced in the body and found certain foods. The aim of this study was to assess effect a bioavailable formulated form PEA (Levagen+®) on serum BDNF levels parameters cognitive function healthy adults. Methods: A randomised double-blinded placebo-controlled cross-over trial implemented measure effects 6-week 700 mg/day course supplementation versus placebo. Participants (n = 39) completed pre- post-assessments lab-based test. Serum samples were collected concentrations using immunoassay. Results: significant increase following compared with placebo (p 0. 0057, d 0.62). cognition test battery demonstrated improved memory through better first success 0.142, 0.54) fewer errors 0.0287; −0.47) Paired Associates Learning Conclusion: This report direct beneficial Levagen+® improvement as well corresponding increases circulating neurotrophic marker levels. suggests that holds promise innovative practical intervention for health enhancement.

Language: Английский

Citations

4
The role of cannabinoid-mediated signaling pathways and mechanisms in brain disorders DOI
Shunfeng Liu, Zegang Ma

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111653 - 111653

Published: Feb. 1, 2025

Language: Английский

Citations

0
Anxiety Modulation by Cannabinoids—The Role of Stress Responses and Coping DOI Open Access
József Haller

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15777 - 15777

Published: Oct. 30, 2023

Endocannabinoids were implicated in a variety of pathological conditions including anxiety and are considered promising new targets for anxiolytic drug development. The optimism concerning the potentials this system anxiolysis is probably justified. However, complexity mechanisms affected by endocannabinoids, discrepant findings obtained with various experimental approaches makes interpretation research results difficult. Here, we review anxiety-related effects three main interventions used to study endocannabinoid system: pharmacological agents active at endocannabinoid-binding sites present on both cell membrane cytoplasm, genetic manipulations targeting cannabinoid receptors, function-enhancers represented inhibitors degradation transport. Binding-site ligands provide inconsistent because they activate multitude concomitantly. More robust particularly function enhancers, which heighten ongoing activation rather than affecting all indiscriminately. enhancement activity appears ameliorate stress-induced without consistent general. Limited evidence suggests that effect achieved promoting coping styles critical situations. These suggest functional signaling development target stress-related disorders.

Language: Английский

Citations

10
The Interplay between 2-Arachidonoylglycerol and Anandamide Amidohydrolase in Neuropathy DOI Open Access
Iddrisu Ibrahim, Joseph Ayariga,

Junhuan Xu

et al.

Published: May 13, 2024

The endocannabinoid system (ECS) is a complex neuromodulatory network in the human body that have enormous impact developing central nervous system, as well modulates various physiological processes. ECS made up of anandamide, 2-arachidonoylglycerol (2-AG), which are responsible for synthesis and degradation endocannabinoids, enzymes such FAAH MAGL ensures precise control over levels. relies on CB1 receptors found (CNS), CB2 peripheral immune cells. Dysregulation has been associated with several health conditions, prompting investigations into its association phytocannabinoids to harness their therapeutic potential. intricately linked it known modulate neuronal activities CNS, influencing pain mood modulation. also neuropathies-peripheral nerve damage leading symptoms weakness, numbness evidenced diabetic neuropathy, Guillain-Barré Syndrome, carpal tunnel syndrome, postherpetic neuralgia. focus this review interplay between anandamide amidohydrolase elucidating roles regulation, inflammation, specific neuropathies. knowledge generated expected broad implications, providing comprehensive insights neuropathic conditions how improve them. Ultimately, understanding may lead more effective treatments improved quality life individuals affected by these conditions.

Language: Английский

Citations

3
Preface: Special issue: 14th International Conference on Brain Energy Metabolism: Energy substrates and microbiome govern brain bioenergetics and cognitive function with aging DOI Open Access
Mary C. McKenna, In‐Young Choi, Arne Schousboe

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 168(5), P. 443 - 449

Published: April 12, 2024

Abstract This Preface introduces the Special Issue entitled, “Energy Substrates and Microbiome Govern Brain Bioenergetics Cognitive Function with Aging”, which is comprised of manuscripts contributed by invited speakers program/organizing committee members who participated in 14th International Conference on Energy Metabolism (ICBEM) held October 24–27, 2022 Santa Fe, New Mexico, USA. The conference covered latest developments research related to neuronal energetics, emerging roles for glycogen higher brain functions, impact dietary intervention aging, memory, Alzheimer's disease, microbiome gut‐brain signaling, astrocyte‐neuron interactions cognition novel mitochondria their metabolites, metabolic neuroimaging aging neurodegeneration. special issue contains 25 these topics plus three tributes outstanding scientists have made important contributions energy metabolism numerous ICBEM conferences. In addition, two describe directions rationale future many thematic areas conference. image

Language: Английский

Citations

1
Informing the Cannabis Conjecture: From Life’s Beginnings to Mitochondria, Membranes and the Electrome—A Review DOI Open Access
Alistair V.W. Nunn,

Geoffrey W. Guy,

Jimmy D. Bell

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13070 - 13070

Published: Aug. 22, 2023

Before the late 1980s, ideas around how lipophilic phytocannabinoids might be working involved membranes and bioenergetics as these disciplines were “in vogue”. However, interest in genetics pharmacology grew, mitochondria (and membranes) waned. The discovery of cognate receptor for tetrahydrocannabinol (THC) led to classification endocannabinoid system (ECS) conjecture that “working” through this system. “why” they beneficial, especially compounds like CBD, remains unclear. Given centrality complex organisms, their evolutionary heritage from beginnings life, revisiting phytocannabinoid action light could enlightening. For example, life can described a self-organising replicating far equilibrium dissipating system, which is defined by movement charge across membrane. Hence building evidence, at least animals, THC CBD modulate mitochondrial function highly informative. In paper, we offer unique perspective question, why do potentially work medicines so many different conditions? answer, suggest, membrane fluidity number ways thus dissipation engender homeostasis, particularly under stress. To understand this, need embrace origins theories, role plants explanations disease ageing an adaptive thermodynamic perspective, well quantum mechanics.

Language: Английский

Citations

1