Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis

Neuropsychopharmacology, Journal Year: 2015, Volume and Issue: 41(1), P. 103 - 125

Published: June 22, 2015

Language: Английский

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Role of the bed nucleus of the stria terminalis in aversive learning and memory

Learning & Memory, Journal Year: 2017, Volume and Issue: 24(9), P. 480 - 491

Published: Aug. 16, 2017

Surviving threats in the environment requires brain circuits for detecting (or anticipating) danger and coordinating appropriate defensive responses (e.g., increased cardiac output, stress hormone release, freezing behavior). The bed nucleus of stria terminalis (BNST) is a critical interface between "affective forebrain"-including amygdala, ventral hippocampus, medial prefrontal cortex-and hypothalamic brainstem areas that have been implicated neuroendocrine, autonomic, behavioral to actual or anticipated threats. However, precise contribution BNST behavior unclear, both terms antecedent stimuli mobilize activity consequent reactions. For example, it well known essential contextual fear conditioning, but dispensable conditioning discrete conditioned (CSs), at least as indexed by behavior. recent evidence suggests there are circumstances which may persist independent BNST. Furthermore, involved reinstatement relapse) extinguished CSs. As such, gaps understanding how contributes fundamental processes Pavlovian conditioning. Here, we attempt provide an integrative account function We discuss distinctions unconditioned role organizing behaviors associated with these states. propose mediates responses-not based on modality duration threat response threat-but rather consequence ability stimulus predict when aversive outcome will occur (i.e., its temporal predictability). argue not uniquely mobilized sustained responses. In contrast, poorly

Language: Английский

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From Stress to Anhedonia: Molecular Processes through Functional Circuits

Trends in Neurosciences, Journal Year: 2018, Volume and Issue: 42(1), P. 23 - 42

Published: Oct. 13, 2018

Language: Английский

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The intersection of stress and reward: BNST modulation of aversive and appetitive states

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2018, Volume and Issue: 87, P. 108 - 125

Published: Jan. 9, 2018

Language: Английский

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Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 103, P. 50 - 59

Published: June 15, 2019

Language: Английский

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Activating Corticotropin-Releasing Factor Systems in the Nucleus Accumbens, Amygdala, and Bed Nucleus of Stria Terminalis: Incentive Motivation or Aversive Motivation?

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 89(12), P. 1162 - 1175

Published: Jan. 22, 2021

Language: Английский

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Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies—potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST)

Cell and Tissue Research, Journal Year: 2018, Volume and Issue: 375(1), P. 143 - 172

Published: July 28, 2018

Language: Английский

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Cell-type specific parallel circuits in the bed nucleus of the stria terminalis and the central nucleus of the amygdala of the mouse

Brain Structure and Function, Journal Year: 2019, Volume and Issue: 224(3), P. 1067 - 1095

Published: Jan. 4, 2019

Language: Английский

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Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis

Handbook of behavioral neuroscience, Journal Year: 2020, Volume and Issue: unknown, P. 63 - 100

Published: Jan. 1, 2020

Language: Английский

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The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 30, 2023

The bed nucleus of the stria terminalis (BNST), as part extended amygdala, has become a region increasing interest regarding its role in numerous human stress-related psychiatric diseases, including post-traumatic stress disorder and generalized anxiety amongst others. BNST is sexually dimorphic highly complex structure already evident by anatomy consisting 11 to 18 distinct sub-nuclei rodents. Located ventral forebrain, anatomically functionally connected many other limbic structures, hypothalamic nuclei, basal ganglia, hippocampus. Given this extensive connectivity, thought play central critical integration information on hedonic-valence, mood, arousal states, processing emotional information, general shape motivated stress/anxiety-related behavior. Regarding regulating behavior anterolateral group (BNSTALG) been extensively studied contains wide variety neurons that differ their electrophysiological properties, morphology, spatial organization, neuropeptidergic content input output synaptic organization which activity function. In addition great diversity, further species-specific differences are multiple levels. For example, classic studies performed adult rat brain identified three neuron types (Type I-III) based properties ion channel expression. Whilst similar have animal species, such mice non-human primates macaques, cross-species comparisons revealed intriguing comparative prevalence BNSTALG well morphological differences. tremendous complexity levels, comprehensive elucidation circuitry major challenge. present Review we bring together highlight key structure, functional profiles between species with aim facilitate future important relation disease.

Language: Английский

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