Cerebral Palsy: Early Markers of Clinical Phenotype and Functional Outcome

Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 8(10), P. 1616 - 1616

Published: Oct. 4, 2019

The Prechtl General Movement Assessment (GMA) has become a cornerstone assessment in early identification of cerebral palsy (CP), particularly during the fidgety movement period at 3–5 months age. Additionally, motor repertoire, such as antigravity movements and postural patterns, which form Motor Optimality Score (MOS), may provide insight into an infant’s later function. This study aimed to identify specific markers for ambulation, gross function (using Gross Function Classification System, GMFCS), topography (unilateral, bilateral), type (spastic, dyskinetic, ataxic, hypotonic) CP large worldwide cohort 468 infants. We found that 95% children with did not have movements, 100% having non-optimal MOS. GMFCS level was strongly correlated An MOS > 14 most likely associated outcomes I or II, whereas IV V were hardly ever 8. A number different patterns more severe functional impairment (GMFCS III–V), including atypical arching persistent cramped-synchronized movements. Asymmetrical segmental unilateral CP. Circular arm dyskinetic demonstrated use contributes understanding prognosis, severity.

Language: Английский

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A Review on Recent Advances of Cerebral Palsy

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 20

Published: July 30, 2022

This narrative review summarizes the latest advances in cerebral palsy and identifies where more research is required. Several studies on were analyzed to generate a general idea of prevalence of, risk factors associated with, classification (CP). Different systems used for CP functional basis also analyzed. Diagnosis along with prevention techniques discussed. State-of-the-art treatment strategies Statistical distribution was performed based selected studies. Prevalence found be 2-3/1000 lives; that can correlated are gestational age birth weight. The identified preconception, prenatal, perinatal, postnatal categories. According evidence, classified into spastic (80%), dyskinetic (15%), ataxic (5%) forms. approaches clinical investigation neurological examinations include magnetic resonance imaging (MRI), biomarkers, cranial ultrasound. procedures medical surgical interventions, physiotherapy, occupational therapy, umbilical milking, nanomedicine, stem cell therapy. Technological advancements most common neuromotor disability lives. highest contributing factor prematurity being underweight. preventions diagnostic like MRI ultrasound used. Treatment cord blood nanomedicine therapy needs investigated further future apply practice. Future indicated context technological among children.

Language: Английский

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Early intervention evidence for infants with or at risk for cerebral palsy: an overview of systematic reviews

Developmental Medicine & Child Neurology, Journal Year: 2021, Volume and Issue: 63(7), P. 771 - 784

Published: April 6, 2021

To perform an overview of systematic reviews and more recent randomized controlled trials (RCTs) on early motor interventions in infants aged 0 to 3 years with or at risk cerebral palsy inform current clinical research efforts provide a benchmark assess future ideally initiated within the first 6 months.Standardized searches PubMed, Embase, Scopus, Web Science databases were conducted for (2009-2020) RCTs (2015-2020).From 840 unique records, 31 full texts reviewed, yielding three encompassing 46 studies, 16 comparison groups, six additional that met criteria. Two enrichment- activity-based approaches had medium effect sizes development, only one low bias; two others large task-specific but some bias concerns; enriched environment studies concerns cognitive development. Most small no sizes, concerns, uncertain diagnostic determinations.Data synthesis revealed limited data quantity quality, suggest, although not yet confirmed, greater benefit from versus later intervention. Research precision earlier intervention are accelerating, which may transform outcomes practices. What this paper adds For over 50% reviews, was compared standard care showing efficacy. Similar results older children, constraint-induced movement therapy (CIMT) emerged as efficacious high sizes. CIMT superior similarly intense bimanual training occupational therapy. Goals-Activity-Motor Enrichment before 5 months age equally care. Several other strategies promoted and/or

Language: Английский

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Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(9), P. 2075 - 2075

Published: April 27, 2019

The etiology of cerebral palsy (CP) is complex and remains inadequately understood. Early detection CP an important clinical objective as this improves long term outcomes. We performed genome-wide DNA methylation analysis to identify epigenomic predictors in newborns investigate disease pathogenesis. Methylation newborn blood using Illumina HumanMethylation450K array was 23 cases 21 unaffected controls. There were 230 significantly differentially-methylated CpG loci 258 genes. Each locus had at least 2.0-fold change versus controls with a FDR p-value ≤ 0.05. level for each area under the receiver operating curve (AUC) ≥ 0.75 detection. Using Artificial Intelligence (AI) platforms/Machine Learning (ML) analysis, levels combination genes 95% sensitivity 94.4% specificity prediction CP. pathway multiple canonical pathways plausibly linked neuronal function over-represented. Altered biological processes functions included: neuromotor damage, malformation major brain structures, growth, neuroprotection, development de-differentiation, cranial sensory neuron development. In conclusion, leucocyte epigenetic changes analyzed AI/ML techniques appeared accurately predict provided plausible mechanistic information on

Language: Английский

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Advances in cerebral palsy biomarkers

Advances in clinical chemistry, Journal Year: 2020, Volume and Issue: unknown, P. 139 - 169

Published: May 23, 2020

Language: Английский

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Clinical Phenotype of Cerebral Palsy Depends on the Cause: Is It Really Cerebral Palsy? A Retrospective Study

Journal of Child Neurology, Journal Year: 2021, Volume and Issue: 37(2), P. 112 - 118

Published: Dec. 13, 2021

Cerebral palsy is the most common motor disability in childhood. Still, precise definition terms of causes and timing brain damage remains controversial. Several studies examine clinical phenotype cerebral types. The aim our study was to determine what extent patients depends on underlying cause. We retrospectively evaluated phenotype, abnormalities during pregnancy, cause 384 patients, treated at Charité-Medicine University, between 2015 2017. identified 79.9% cases. Causes prior perinatal period were, compared damage, associated significantly with different comorbidities. term does not describe a single disease but an umbrella covering many diseases. Depending cause, varying can be found, which offers great potential individual treatment preventing

Language: Английский

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Cerebral palsy: current status of the problem (review of literature)

Russian Journal of Child Neurology, Journal Year: 2025, Volume and Issue: 19(4), P. 20 - 28

Published: Jan. 22, 2025

The article presents an overview of current literature data on the description risk factors, epidemiology, etiology, clinical presentation, diagnosis, prevention and treatment cerebral palsy (CP). Cerebral is most common pathology that leads to disability in childhood, with impaired motor function as a result damage central nervous system. With CP, there wide range disorders disrupt daily activities child. In addition, cognitive behavioral problems, communication disorders, appearance epileptic seizures are possible. Previously it was believed cause CP lack oxygen at birth. However, modern research has established that, along this, many other causes factors together brain during ontogenesis contribute development pathological process. This review aims highlight developments field identify new avenues for future this area.

Language: Английский

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Remote screening protocol for functioning and contextual factors (e-Followkids) in Brazilian children with biological risk in the first 2 years: A longitudinal prospective study

Infant Behavior and Development, Journal Year: 2025, Volume and Issue: 79, P. 102054 - 102054

Published: March 30, 2025

Language: Английский

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Early Diagnosis and Differential Diagnosis of Cerebral Palsy

Published: Jan. 1, 2025

Language: Английский

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A Call for Early Detection of Cerebral Palsy

NeoReviews, Journal Year: 2023, Volume and Issue: 25(1), P. e1 - e11

Published: Dec. 31, 2023

Abstract Cerebral palsy (CP) is the most common physical disability across lifespan, but historically, CP has not been diagnosed before age of 2 years. Barriers to early diagnosis ranged from lack available biomarkers, absence curative treatments, perceived stigma associated with a lifelong diagnosis, and desire rule out other diagnoses first. Most importantly, fundamental question that remained was whether children would benefit earlier detection intervention given paucity research. However, evidence-based guidelines published in 2017 demonstrated General Movements Assessment, Hammersmith Infant Neurological Examination, neuroimaging can be combined elements such as clinical history standardized motor assessments provide highest predictive value for diagnosing 3 months high-risk newborns. Implementation these successful decreasing at particularly infant follow-up clinics expertise performing assessments. Early allows research opportunities investigating interventions during critical period neuroplasticity, goal improving developmental trajectories their families. New are now being developed focus on early, targeted continue studied, along global initiatives.

Language: Английский

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