Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis DOI Creative Commons
Xintong Wang, Zixu Wang, Jing Cao

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: July 16, 2021

Objectives: Memory decline caused by insufficient sleep is a critical public health issues and currently lacks effective treatments. This study objective was to explore alleviative effect of melatonin on deprivation (SD)-induced deficiencies in learning memory. Materials Methods: A continuous 72 h SD mouse model, with or without Fer-1 supplementation were established. The changes cognitive function, iron homeostasis, lipid peroxidation intracellular signal pathways mice detected Morris water maze, antioxidant assay, immunohistochemistry, western blot, RT-PCR Prussian blue staining. In vitro , we treated HT-22 cells ferroptosis inducer (Erastin) further the specific mechanism ferroptosis. Results: Mice subjected had significantly elevated latency path length reach hidden platform, as well decrease number entries time spent target zone when platform removed ( p < 0.05). Nevertheless, inhibitor (Fer-1) mitigated memory impairment associated SD. Further evaluation revealed an up-regulation accumulation, transferrin receptor 1 divalent metal transporter expression ROS MDA production, down-regulation ferroportin enzyme (GPX4 SOD) mice. decreased MT2 rather than MT1, inhibited ERK/Nrf2 signaling activation hippocampus contrast, aforementioned SD-inductions reversed using 20 40 mg/kg pretreatment Erastin-induced ferroptosis, abnormalities protein suppression cells, however this protective blocked MT2-, ERK- Nrf2-specific antagonists Conclusion: Our finding suggested may induce turn leading deficits. Melatonin alleviated loss hippocampal acute through binding activate signaling.

Language: Английский

Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities DOI Creative Commons
Runyu Miao, Xinyi Fang, Yanjiao Zhang

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(3)

Published: March 8, 2023

Abstract The maintenance of iron homeostasis is essential for proper endocrine function. A growing body evidence suggests that imbalance a key factor in the development several diseases. Nowadays, ferroptosis, an iron-dependent form regulated cell death, has become increasingly recognized as important process to mediate pathogenesis and progression type 2 diabetes mellitus (T2DM). It been shown ferroptosis pancreas β cells leads decreased insulin secretion; liver, fat, muscle induces resistance. Understanding mechanisms concerning regulation metabolism T2DM may lead improved disease management. In this review, we summarized connection between metabolic pathways molecular T2DM. Additionally, discuss potential targets treating analysis current limitations future directions these novel treatment targets.

Language: Английский

Citations

85
Evidence for the Benefits of Melatonin in Cardiovascular Disease DOI Creative Commons
Mohammad Tobeiha, Ameneh Jafari, Sara Fadaei

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: June 20, 2022

The pineal gland is a neuroendocrine which produces melatonin, hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle. Melatonin has been shown to possess anti-oxidant activity neuroprotective properties. Numerous studies have that melatonin significant functions cardiovascular disease, may anti-aging ability of decrease primary hypertension needs be more extensively evaluated. benefits reducing cardiac pathology, preventing death muscle response ischemia-reperfusion rodent species. Moreover, also prevent hypertrophy heart under some circumstances, turn would lessen development failure. Several currently used conventional drugs show cardiotoxicity as an adverse effect. Recent acts effective suppressing damage mediated by pharmacologic drugs. Therefore, cardioprotective multiple animal human studies. Herein, we summarize most established system focus on molecular mechanisms action.

Language: Английский

Citations

78
Mechanistic insights on melatonin-mediated plant growth regulation and hormonal cross-talk process in solanaceous vegetables DOI
Muhammad Ahsan Altaf, Nitin Sharma,

Jagmohan Singh

et al.

Scientia Horticulturae, Journal Year: 2022, Volume and Issue: 308, P. 111570 - 111570

Published: Oct. 14, 2022

Language: Английский

Citations

74
Melatonin as a key regulator in seed germination under abiotic stress DOI Open Access
Lei Wang, Mohsin Tanveer, Hongling Wang

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(1)

Published: Jan. 1, 2024

Abstract Seed germination (SG) is the first stage in a plant's life and has an immense importance sustaining crop production. Abiotic stresses reduce SG by increasing deterioration of seed quality, reducing potential, vigor. Thus, to achieve sustainable level yield, it important improve under abiotic stress conditions. Melatonin (MEL) biomolecule that interplays developmental processes regulates many adaptive responses plants, especially stresses. this review specifically summarizes discusses mechanistic basis MEL‐mediated MEL regulating some stress‐specific common responses. For instance, induced specific include regulation ionic homeostasis, hydrolysis storage proteins salinity stress, C‐repeat binding factors signaling cold starch metabolism high temperature heavy metal activation aquaporins accumulation osmolytes drought stress. On other hand, mediated gibberellins biosynthesis abscisic acid catabolism, redox Ca 2+ are amongst Nonetheless such as endogenous contents, plant species, growth conditions also influence above‐mentioned In conclusion, interacting with different physiological mechanisms.

Language: Английский

Citations

22
Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management DOI

K. B. Megha,

A. Arathi,

Saini Shikha

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5541 - 5571

Published: Jan. 11, 2024

Language: Английский

Citations

19
Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans DOI Creative Commons
Bahare Salehi, Farukh Sharopov, Patrick Valère Tsouh Fokou

et al.

Cells, Journal Year: 2019, Volume and Issue: 8(7), P. 681 - 681

Published: July 5, 2019

Melatonin is a widespread molecule among living organisms involved in multiple biological, hormonal, and physiological processes at cellular, tissue, organic levels. It well-known for its ability to cross the blood-brain barrier, renowned antioxidant effects, acting as free radical scavenger, up-regulating enzymes, reducing mitochondrial electron leakage, interfering with proinflammatory signaling pathways. Detected various medicinal food plants, concentration widely variable. Plant generative organs (e.g., flowers, fruits), especially seeds, have been proposed having highest melatonin concentrations, markedly higher than those found vertebrate tissues. In addition, seeds are also rich other substances (lipids, sugars, proteins), constituting energetic reserve potentially growing seedling beneficial human diet. Thus, given that dietary absorbed gastrointestinal tract transported into bloodstream, ingestion of plant foods by mammals source may be conceived key step serum modulation and, consequently, health promotion.

Language: Английский

Citations

144
Melatonin as Master Regulator in Plant Growth, Development and Stress Alleviator for Sustainable Agricultural Production: Current Status and Future Perspectives DOI Open Access

Khadija Nawaz,

Rimsha Chaudhary,

Ayesha Sarwar

et al.

Sustainability, Journal Year: 2020, Volume and Issue: 13(1), P. 294 - 294

Published: Dec. 30, 2020

Melatonin, a multifunctional signaling molecule, is ubiquitously distributed in different parts of plant and responsible for stimulating several physiochemical responses against adverse environmental conditions various systems. Melatonin acts as an indoleamine neurotransmitter primarily considered antioxidant agent that can control reactive oxygen nitrogen species plants. being agent, induces specific physiological plants might serve to enhance photosynthesis, growth, carbon fixation, rooting, seed germination defense biotic abiotic stressors. It also works important modulator gene expression related hormones such the metabolism indole-3-acetic acid, cytokinin, ethylene, gibberellin auxin carrier proteins. Additionally, regulation stress-specific genes activation pathogenesis-related protein enzyme under stress make it more versatile molecule. Because diversity action melatonin, its role development, behavior plant’s master regulator. This review outlines main functions melatonin physiology, development higher Its anti-stressor stressors, drought, salinity, temperatures, UV radiation toxic chemicals, analyzed critically. we have identified many new aspects where may possible roles plants, example, function improving storage life quality fruits vegetables, which be useful enhancing environmentally friendly crop production ensuring food safety.

Language: Английский

Citations

129
Melatonin: Another avenue for treating osteoporosis? DOI Open Access
Tian Li, Shuai Jiang,

Chenxi Lu

et al.

Journal of Pineal Research, Journal Year: 2018, Volume and Issue: 66(2)

Published: Dec. 31, 2018

Abstract Melatonin is a signal molecule that modulates the biological circadian rhythms of vertebrates. deficiency thought to be associated with several disorders, including insomnia, cancer, and cardiovascular neurodegenerative diseases. Accumulating evidence has also indicated melatonin may involved in homeostasis bone metabolism. Age‐related reductions are considered critical factors loss osteoporosis aging. Thus, serum levels might serve as biomarker for early detection prevention osteoporosis. Compared conventional antiosteoporosis medicines, which primarily inhibit loss, both suppresses promotes new formation. Mechanistically, by activating receptor 2 (MT2), upregulates gene expression alkaline phosphatase (ALP), morphogenetic protein (BMP2), BMP6, osteocalcin, osteoprotegerin promote osteogenesis while inhibiting activator NF‐kB ligand (RANKL) pathway suppress osteolysis. In view distinct actions on metabolism, we hypothesize novel remedy clinical treatment

Language: Английский

Citations

122
Exogenous melatonin applying confers chilling tolerance in pomegranate fruit during cold storage DOI
Abbasali Jannatizadeh

Scientia Horticulturae, Journal Year: 2018, Volume and Issue: 246, P. 544 - 549

Published: Nov. 26, 2018

Language: Английский

Citations

117
Melatonin in Mitochondria: Mitigating Clear and Present Dangers DOI Open Access
Russel J. Reıter, Qiang Ma, Ramaswamy Sharma

et al.

Physiology, Journal Year: 2020, Volume and Issue: 35(2), P. 86 - 95

Published: Feb. 6, 2020

In cancer cells, glucose is primarily metabolized to pyruvate and then lactate in the cytosol. By allowing conversion of acetyl-CoA mitochondria, melatonin reprograms metabolism cells a normal cell phenotype. Acetyl-CoA mitochondria also serves as necessary co-factor for rate-limiting enzyme synthesis, thus ensuring production cells.

Language: Английский

Citations

109