Insomnia – An outlook for the future DOI Open Access
Dieter Riemann, Kai Spiegelhalder

Journal of Sleep Research, Journal Year: 2023, Volume and Issue: 32(6)

Published: Oct. 12, 2023

Not applicable.

Language: Английский

The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023 DOI Creative Commons
Dieter Riemann, Colin A. Espie, Ellemarije Altena

et al.

Journal of Sleep Research, Journal Year: 2023, Volume and Issue: 32(6)

Published: Nov. 28, 2023

Summary Progress in the field of insomnia since 2017 necessitated this update European Insomnia Guideline. Recommendations for diagnostic procedure and its comorbidities are: clinical interview (encompassing sleep medical history); use questionnaires diaries (and physical examination additional measures where indicated) (A). Actigraphy is not recommended routine evaluation (C), but may be useful differential‐diagnostic purposes Polysomnography should used to evaluate other disorders if suspected (i.e. periodic limb movement disorder, sleep‐related breathing disorders, etc.), treatment‐resistant (A) indications (B). Cognitive‐behavioural therapy as first‐line treatment chronic adults any age (including patients with comorbidities), either applied in‐person or digitally When cognitive‐behavioural sufficiently effective, a pharmacological intervention can offered Benzodiazepines (A), benzodiazepine receptor agonists daridorexant low‐dose sedating antidepressants (B) short‐term (≤ 4 weeks). Longer‐term these substances initiated some cases, considering advantages disadvantages Orexin antagonists periods up 3 months longer cases Prolonged‐release melatonin ≥ 55 years Antihistaminergic drugs, antipsychotics, fast‐release melatonin, ramelteon phytotherapeutics are Light exercise interventions adjunct therapies

Language: Английский

Citations

231

Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: results of European neuropsychopharmacology and sleep expert’s consensus group DOI
Laura Palagini,

Roberto Brugnoli,

Bernardo M Dell' Osso

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 128, P. 117 - 126

Published: Jan. 31, 2025

Language: Английский

Citations

2

Insomnia, anxiety and related disorders: a systematic review on clinical and therapeutic perspective with potential mechanisms underlying their complex link DOI Creative Commons
Laura Palagini, Mario Miniati, Valerio Caruso

et al.

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 103936 - 103936

Published: Jan. 1, 2024

Anxiety and anxiety-related disorders are the most common mental disturbances, with dysregulation in emotions cognition as central features. Since function of sleep regulating is quintessential stress response inflammation, disturbances may be ideal modifiable factors anxiety related disorders. Accordingly, aim review was to systematically association between insomnia symptoms A systematic search has been conducted, 93 papers have selected for General Disorder, Panic Disorders, Social Separation anxiety, Obsessive Compulsive Disorder Post Traumatic Stress according PRISMA. This represents a comprehensive overview clinical therapeutic approaches framework discussion potential mechanisms underlying their complex link.

Language: Английский

Citations

12

Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression? DOI Creative Commons
Dieter Riemann, Raphael J. Dressle, Fee Benz

et al.

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Summary The world‐wide prevalence of insomnia disorder reaches up to 10% the adult population. Women are more often afflicted than men, and is a risk factor for somatic mental illness, especially depression anxiety disorders. Persistent hyperarousals at cognitive, emotional, cortical and/or physiological levels central most theories regarding pathophysiology insomnia. Of defining features disorder, discrepancy between minor objective polysomnographic alterations sleep continuity substantive subjective impairment in remains enigmatic. Microstructural alterations, rapid eye movement (“rapid instability”), might explain this mismatch findings. As represents highly aroused brain state during sleep, it be particularly prone fragmentation individuals with persistent hyperarousal. In consequence, mentation may toned as conscious‐like wake experience, reflecting pre‐sleep concerns. It suggested that instability involved measures disorder. Furthermore, has been linked previous works emotional processing, could play role close association depressive

Language: Английский

Citations

9

Evaluation and management of insomnia in the clinical practice in Italy: a 2023 update from the Insomnia Expert Consensus Group DOI
Laura Palagini, Raffaele Manni, Claudio Liguori

et al.

Journal of Neurology, Journal Year: 2023, Volume and Issue: 271(4), P. 1668 - 1679

Published: Dec. 8, 2023

Language: Английский

Citations

13

Huanglian Wendan Decoction Improves Insomnia in Rats by Regulating BDNF/TrkB Signaling Pathway Through Gut Microbiota-Mediated SCFAs and Affecting Microglia Polarization DOI
Min Shi, Jie Yang, Ying Liu

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Language: Английский

Citations

4

Epigenetics of childhood obesity DOI Creative Commons
Maria Keller, Mandy Vogel, Antje Garten

et al.

Hormone Research in Paediatrics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Jan. 14, 2025

Background: Childhood obesity has become a global pandemic and is one of the strongest risk factors for cardiovascular disease later in life. The correlation epigenetic marks with related traits being elucidated. This review summarizes latest research its challenges study epigenetics (childhood) obesity. Summary: Epigenome-wide association studies helped to identify novel targets methylation sites that are important pathophysiology In future, such will essential developing scores (MRS) metabolic diseases. Although MRS very promising predicting individual obesity, implementation challenging not been introduced into clinical practice so far. Key Messages: Future undoubtedly discover numerous may be involved development comorbidities, especially at young age. contribute better understanding complex etiology human From perspective, overarching aim generate robust reliable accurate prediction comorbidities.

Language: Английский

Citations

0

Circadian aspects in nonpharmacologic and pharmacologic treatment of insomnia DOI
Laura Palagini, Pierre A. Geoffroy, Raffaele Manni

et al.

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 161 - 179

Published: Jan. 1, 2025

Language: Английский

Citations

0

Associations Between Transdiagnostic Psychological Processes and Global Symptom Severity Among Outpatients With Various Mental Disorders: A Cross‐Sectional Study DOI Creative Commons
Anna Katharina Frei,

Thomas Studnitz,

Britta Seiffer

et al.

Clinical Psychology & Psychotherapy, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 1, 2025

ABSTRACT Objective Knowledge about transdiagnostic factors associated with global symptom severity among patients diagnosed various mental disorders remains limited. This study examined the cross‐sectional associations between processes including emotion regulation and specific strategies (i.e., amount of physical activity sedentary behaviour, repetitive negative thinking sleep routines) severity, while controlling for sociodemographic data (age, gender, employment status, relationship educational level) fear coronavirus. Methods Data from 401 outpatients, aged 42.08 years on average ( SD = 13.26; 71.3% female), depressive disorders, non‐organic primary insomnia, agoraphobia, panic disorder and/or post‐traumatic stress were examined. is a secondary analysis randomized controlled trial. collected 10 different sites March 2021 May 2022 analysis. The influence predictors was determined using three‐step hierarchical multiple regression: (1) control variables, (2) (3) strategies. Global measured Severity Index, derived Brief Symptom Inventory‐18. Predictors validated scales, additionally assessed via accelerometer‐based sensors. Results In first step, variables accounted 4% variance in severity. inclusion second step explained 26% outcome variance, incorporation third increased to 37%. Significant included β 0.28), 0.26) routines 0.25). Conclusion along as are identified psychological that may serve treatment targets evidence‐based interventions designed enhance regulation, particularly samples stress‐related disorders. Additional prospective longitudinal studies necessary explore possible causal relationships.

Language: Английский

Citations

0

The Dynamics of Epigenetic Influence in Insomnia: A Higher-Order Adaptive Modeling Perspective DOI

Sarah Hassouna,

Jan Treur, Sophie C. F. Hendrikse

et al.

Lecture notes in computer science, Journal Year: 2025, Volume and Issue: unknown, P. 312 - 325

Published: Jan. 1, 2025

Language: Английский

Citations

0