Nutrients,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2624 - 2624
Published: June 3, 2023
Telomere
length
(TL)
is
a
well-known
marker
of
age-related
diseases.
Oxidative
stress
and
inflammation
increase
the
rate
telomere
shortening,
triggering
cellular
senescence.
Although
lipoproteins
could
have
anti-inflammatory
proinflammatory
functional
properties,
relationship
between
lipoprotein
particles
with
TL
telomerase
activity-related
genes
has
not
been
investigated
much.
In
this
study,
we
assessed
associations
subfractions
length,
TERT,
WRAP53
expression
in
total
54
pre-diabetic
subjects
from
EPIRDEM
study.
We
regressed
TL,
on
12
subclasses,
employing
Gaussian
linear
regression
method
Lasso
penalty
to
determine
profile
associated
telomere-related
parameters.
The
covariates
included
age,
sex,
body
mass
index
(BMI),
dyslipidemia,
statin
consumption,
physical
activity
leisure
time.
identified
composed
four
(Pearson
r
=
0.347,
p-value
0.010),
two
TERT
0.316,
0.020),
five
0.379,
=0.005).
After
adjusting
for
known
confounding
factors,
most
profiles
maintained
association
WRAP53.
Overall,
medium
small-sized
HDL
were
shorter
telomeres
lower
Large
longer
WRAP53,
but
TERT.
Our
results
suggest
that
are
should
be
considered
when
assessing
risk
chronic
Ageing Research Reviews,
Journal Year:
2023,
Volume and Issue:
85, P. 101854 - 101854
Published: Jan. 17, 2023
Telomere
attrition
is
considered
a
hallmark
of
ageing.
Untangling
the
proximate
causes
telomere
may
therefore
reveal
important
aspects
about
ageing
process.
In
landmark
paper
in
2002
Thomas
von
Zglinicki
demonstrated
that
oxidative
stress
accelerates
cell
culture.
next
20
years,
became
firmly
embedded
into
modern
theories
and
attrition.
However,
recent
surge
vivo
studies
reveals
an
inconsistent
pattern
questioning
unequivocal
role
length
(henceforth
referred
to
as
dynamics),
living
organisms.
Here
we
report
results
first
formal
meta-analysis
on
association
between
dynamics
vivo,
representing
37
studies,
4969
individuals,
18,677
correlational
measurements.
The
overall
correlation
markers
was
indistinguishable
from
zero
(r
=
0.027).
This
result
independent
type
marker,
dynamic,
or
taxonomic
group.
measurement
method
affected
analysis
subset
TRF-based
showed
significant
0.09),
supporting
prediction
more
pronounced
short-lived
species
during
adult
life
phase,
when
becomes
apparent.
We
then
performed
additional
interventional
(n
7)
manipulating
stress.
revealed
effect
treatment
(d=0.36).
Our
findings
provide
new
support
for
hypothesis
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(18), P. 14279 - 14279
Published: Sept. 19, 2023
Aging
is
considered
the
deterioration
of
physiological
functions
along
with
an
increased
mortality
rate.
This
scientific
review
focuses
on
central
importance
genomic
instability
during
aging
process,
encompassing
a
range
cellular
and
molecular
changes
that
occur
advancing
age.
In
particular,
this
revision
addresses
genetic
epigenetic
alterations
contribute
to
instability,
such
as
telomere
shortening,
DNA
damage
accumulation,
decreased
repair
capacity.
Furthermore,
explores
aging,
including
modifications
histones,
methylation
patterns,
role
non-coding
RNAs.
Finally,
discusses
organization
chromatin
its
contribution
heterochromatin
loss,
remodeling,
in
nucleosome
histone
abundance.
conclusion,
highlights
fundamental
plays
process
underscores
need
for
continued
research
into
these
complex
biological
mechanisms.
Agronomy,
Journal Year:
2023,
Volume and Issue:
13(4), P. 1174 - 1174
Published: April 20, 2023
Heavy
metals
(HMs)
stress,
particularly
lead
(Pb)
is
one
of
the
most
hazardous
environmental
stresses
that
can
negatively
affect
plants’
growth,
yield,
and
quality.
Therefore,
effects
zinc
oxide
nanoparticles
(ZnO-NPs;
50
mg
L−1),
nano-hydroxyapatite
(HP-NPs;
kg−1),
their
combination
on
physiological,
yield
traits
maize
grown
in
soil
contaminated
with
Pb
(i.e.,
100
kg−1)
were
investigated.
The
results
showed
stress
significantly
reduced
plant
leaf
area
by
50.9%
at
40
days
after
sowing
(DAS),
55.5%
70
DAS,
54.2%
DAS
comparison
to
unstressed
plants
(control).
However,
combined
application
ZnO-NPs
(50
L−1)
+
HP-NPs
adverse
growth
terms
increasing
117.6%
Pb-contaminated
(100
kg−1).
Similarly,
resulted
increments
total
chlorophyll
content
47.1%,
photosynthesis
rate
255.1%,
stomatal
conductance
380%
obtained
from
stressed
Pb.
On
other
hand,
antioxidants
such
as
sodium
dismutase
(SOD;
87.1%),
peroxidase
(POX;
90.8%),
catalase
(CAT;
146%),
proline
(116%)
increased
a
result
compared
plants.
Moreover,
N,
P,
K,
Zn
contents
whole
under
decreased
38.7%,
69.9%,
46.8%,
82.1%,
respectively,
those
control.
Whereas
treatment
uptake
nutrients
and,
consequently,
highest
values
ear
weight,
grain
harvest
index
obtained.
Furthermore,
biomass
77.6%
grains
90.21%
exposed
stress.
In
conclusion,
improved
physiological
traits,
antioxidants,
well
elemental
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
Journal of Experimental Biology,
Journal Year:
2024,
Volume and Issue:
227(Suppl_1)
Published: March 7, 2024
ABSTRACT
Exposure
to
stress
during
early
life
may
alter
the
developmental
trajectory
of
an
animal
by
a
mechanism
known
as
adaptive
plasticity.
For
example,
enhance
reproductive
success
in
adverse
environment,
it
is
that
animals
accelerate
their
growth
development.
However,
these
short-term
fitness
benefits
are
often
associated
with
reduced
longevity,
phenomenon
rate–lifespan
trade-off.
In
humans,
exposure
compromises
health
later
and
increases
disease
susceptibility.
Glucocorticoids
(GCs)
major
hormones
implicated
processes.
This
Review
discusses
evidence
for
GC-mediated
plasticity
development,
leading
allostatic
overload
life.
We
focus
on
GC-induced
effects
brain
structure
function,
including
neurogenesis;
highlight
need
longitudinal
studies;
discuss
approaches
identify
molecular
mechanisms
mediating
alteration
adult
dysfunctions.
Further
understanding
how
GC
can
trajectories
at
cellular
level
critical
importance
reduce
burden
mental
physical
ill
across
course.
