Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(18), P. 5610 - 5623
Published: April 27, 2022
Pu-erh
tea
is
a
healthy
beverage
rich
in
phytochemicals,
and
its
effect
on
the
risk
of
inducing
circadian
rhythm
disorders
(CRD)
unclear.
In
this
study,
mice
were
given
water
or
0.25%
(w/v)
for
7
weeks,
followed
by
40
day
disruption
light/dark
cycle.
CRD
caused
dysregulation
neurotransmitter
secretion
clock
gene
oscillations,
intestinal
inflammation,
microbes
metabolites.
boosted
indole
5-hydroxytryptamine
pathways
tryptophan
metabolism
via
gut-liver-brain
axis.
Furthermore,
metabolites
(e.g.,
IAA,
Indole,
5-HT)
enhanced
hepatic
glycolipid
down-regulated
oxidative
stress
improving
brain
hormone
release.
Tryptophan
bile
acids
also
promoted
liver
lipid
inhibited
inflammation
(MyD88/NF-κB)
enterohepatic
circulation.
Collectively,
has
potential
to
prevent
promoting
5-HT
signaling
interactions
Foods,
Journal Year:
2022,
Volume and Issue:
11(18), P. 2863 - 2863
Published: Sept. 15, 2022
The
gut
microbiota
and
their
metabolites
could
play
an
important
role
in
health
diseases
of
human
beings.
Short-chain
fatty
acids
(SCFAs)
are
mainly
produced
by
microbiome
fermentation
dietary
fiber
also
be
bacteria
the
skin
vagina.
Acetate,
propionate,
butyrate
three
major
SCFAs,
bioactivities
have
been
widely
studied.
SCFAs
many
benefits,
such
as
anti-inflammatory,
immunoregulatory,
anti-obesity,
anti-diabetes,
anticancer,
cardiovascular
protective,
hepatoprotective,
neuroprotective
activities.
This
paper
summarizes
benefits
side
effects
with
a
special
attention
paid
to
mechanisms
action.
provides
better
support
for
people
eating
well
ways
developed
into
functional
food
prevent
diseases.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(8), P. 2592 - 2592
Published: July 28, 2021
Threonine
(Thr),
an
essential
amino
acid
for
animals
and
the
limiting
in
swine
poultry
diets,
which
plays
a
vital
role
modulation
of
nutritional
metabolism,
macromolecular
biosynthesis,
gut
homeostasis.
Current
evidence
supports
that
supplementation
Thr
leads
to
benefits
terms
energy
metabolism.
is
not
only
important
component
gastrointestinal
mucin,
but
also
acts
as
modulator
influences
intestinal
immune
system
via
complex
signaling
networks,
particularly
mitogen-activated
protein
kinase
(MAPK)
target
rapamycin
(TOR)
signal
pathway.
recognized
indispensable
nutrient
cell
growth
proliferation.
Hence,
optimization
requirement
may
exert
favorable
impact
on
factors
linked
health
diseases
animals.
This
review
focuses
latest
reports
metabolic
pathways
regulation,
well
relationship
between
relevant
physiological
functions.
Microbiology Insights,
Journal Year:
2023,
Volume and Issue:
16
Published: Jan. 1, 2023
Evidence
indicates
that
short-chain
fatty
acids
(SCFAs)
generated
from
the
gut
microbiota
play
crucial
roles
in
host
metabolism.
They
contribute
to
metabolic
regulation
and
energy
acquisition
of
by
influencing
development
disorders.
This
review
aims
synthesize
recent
advances
literature
investigate
implication
SCFAs
modulation
obesity
diabetes
pathologies.
For
a
better
understanding
relationships
between
metabolism,
we
need
answer
some
questions:
What
is
biochemistry
SCFAs,
how
they
are
microbiota?
bacteria
producing
which
routes?
How
absorbed
transported
different
mechanisms
receptors?
involved
pathologies?
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 12, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
characterized
by
fat
accumulation
and
inflammation.
Epigallocatechin
gallate
(EGCG)
has
been
proven
to
be
effective
against
NAFLD,
but
its
hepatoprotective
mechanisms
based
on
the
"gut
microbiota-barrier-liver
axis"
are
still
not
fully
understood.
Herein,
results
demonstrated
that
EGCG
effectively
ameliorated
NAFLD
phenotypes
metabolic
disorders
in
rats
fed
a
high-fat
diet
(HFD),
inhibited
intestinal
barrier
dysfunction
inflammation,
which
also
supported
experiment
of
Caco-2
cells.
Moreover,
could
restore
gut
microbiota
diversity
composition,
particularly
promoting
beneficial
microbes,
including
short-chain
acids
(SCFAs)
producers,
such
as
Lactobacillus,
suppressing
Gram-negative
bacteria,
Desulfovibrio.
The
microbial
modulation
raised
SCFA
levels,
decreased
lipopolysaccharide
TLR4/NF-κB
pathway,
strengthened
function
via
Nrf2
pathway
activation,
thereby
alleviating
steatosis
Spearman's
correlation
analysis
showed
24
key
OTUs,
negatively
or
positively
associated
with
disorders,
were
reshaped
EGCG.
Our
suggested
combinative
improvement
dysbiosis,
dysfunction,
inflammation
might
potential
therapeutic
target
for
NAFLD.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 5, 2024
Diet-induced
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
prevalent
disorder
with
limited
effective
interventions
available.
A
novel
approach
to
address
this
issue
through
gut
microbiota-based
therapy.
In
our
study,
we
utilized
multi-omics
analysis
identify
Phocaeicola
vulgatus
(P.
vulgatus)
as
potential
probiotic
for
the
treatment
of
MASLD.
Our
findings
from
murine
models
clearly
illustrate
that
supplementation
P.
mitigates
development
This
beneficial
effect
partly
attributed
metabolite
3-Hydroxyphenylacetic
acid
(3-HPAA)
produced
by
vulgatus,
which
reduces
acetylation
levels
H3K27
and
downregulates
transcription
Squalene
Epoxidase
(SQLE),
rate-limiting
enzyme
in
steroid
biosynthesis
promotes
lipid
accumulation
cells.
study
underscores
significant
role
MASLD
critical
importance
its
3-HPAA
regulating
homeostasis.
These
offer
promising
avenue
early
intervention
therapy
context
Critical Reviews in Food Science and Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 14
Published: Jan. 8, 2024
Short-chain
fatty
acids
(SCFAs)
are
a
subset
of
that
play
crucial
roles
in
maintaining
normal
physiology
and
developing
metabolic
diseases,
such
as
obesity,
diabetes,
cardiovascular
disease,
liver
disease.
Even
though
dairy
products
vegetable
oils
the
direct
dietary
sources
SCFAs,
their
quantities
highly
restricted.
SCFAs
produced
indirectly
through
microbial
fermentation
fibers.
The
biological
human
health
diseases
mainly
due
to
receptors,
GPR41
GPR43,
FFAR2
FFAR3.
Additionally,
it
has
been
demonstrated
modulate
DNMTs
HDAC
activities,
inhibit
NF-κB-STAT
signaling,
regulate
G(i/o)βγ-PLC–PKC–PTEN
signaling
PPARγ-UCP2-AMPK
autophagic
thus
mitigating
diseases.
Recent
studies
have
uncovered
epigenetic
modifications
DNAs,
RNAs,
post-translational
proteins,
which
critical
regulators
At
same
time,
recommendations
for
purpose
proposed.
objective
review
is
summarize
most
recent
research
on
role
especially
signal
transduction
functional
efficacy
different
backgrounds
models
at
provide
nutritional
using
food
ingredients
prevent
