Impact of psychosocial factors on medication level variability index and outcomes in pediatric liver transplant recipients DOI
Shruti Sakhuja, Ryan Himes,

Colleen Carreker

et al.

Pediatric Transplantation, Journal Year: 2022, Volume and Issue: 27(1)

Published: Nov. 2, 2022

Caregivers play an important role in maintaining a functioning graft after pediatric liver transplantation. Therefore, the psychosocial factors of both patients and caregivers can have critical impact on transplant outcomes. Appropriate assessment recognition these pre-transplantation may allow teams to better define needs organ recipients develop specific countermeasures, which then contribute toward improving outcomes.We studied 136 LT followed at Texas Children's Hospital. Licensed social workers conducted comprehensive pre-transplant assessments each patient, consisting 22 variables that were thought adherence, reviewed during our study period. Non-adherence was determined using MLVI for up 4 years Biopsy-confirmed rejection episodes assessed first 3 transplantation.Factors significantly associated with non-adherence (defined as >2) included parental age education level assessment, type insurance, household income. The number ACR trended higher non-adherence, had moderate severe but this trend not statistically significant.Psychosocial characteristics such age, level, income suboptimal adherence medications Identification early intervention is essential success equitable care recipients.

Language: Английский

Experience of post-traumatic growth among parents of children with biliary atresia undergoing living-related liver transplantation: a descriptive phenomenological study DOI Creative Commons
Zhi‐Ru Li, FangYan Lu, Dong Li

et al.

European journal of psychotraumatology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 9, 2025

Objectives: To explore the experience of post-traumatic growth among parents children with biliary atresia undergoing living-related liver transplantation.

Language: Английский

Citations

0
The burden of Alagille syndrome: uncovering the potential of emerging therapeutics – a comprehensive systematic literature review DOI
Philip Bufler, Robin Howard,

Lucia Quadrado

et al.

Journal of Comparative Effectiveness Research, Journal Year: 2025, Volume and Issue: 14(2)

Published: Jan. 27, 2025

Aim: Alagille syndrome (ALGS) is a rare, cholestatic multiorgan disease associated with bile duct paucity, leading to cholestasis. Clinical symptoms of cholestasis include debilitating pruritus, xanthomas, fat-soluble vitamin deficiencies, growth failure, renal and impaired health-related quality life (HRQoL). The main objective was review the current literature on epidemiological, clinical, psychosocial economic burden ALGS in view development ileal acid transporter (IBAT) inhibitors. Methods: Electronic databases were searched accordance Preferred Reporting Items for Systematic Reviews Meta-Analyses checklist. Results: 330 publications screened, 119 relevant: 11 randomized controlled trials (RCTs), 21 non-RCTs, 10 HRQoL studies, two studies assessing cost/resource use 77 epidemiological across several through 31 July 2024. Studies confirm that patients experience cardiac anomalies, growth, disease, poor HRQoL, deficiencies pruritus; until approval IBAT inhibitors treatment pruritus ALGS, supportive management standard care. Conclusion: This confirms substantial consolidates evidence. Data from recent demonstrate potential impact transform lives by improving symptoms, native liver survival.

Language: Английский

Citations

0
Adherence to Medication During Transition to Adult Services DOI Open Access
Bianca R. Campagna,

Kristen Weatherley,

Eyal Shemesh

et al.

Pediatric Drugs, Journal Year: 2020, Volume and Issue: 22(5), P. 501 - 509

Published: Sept. 5, 2020

Language: Английский

Citations

27
Pediatric Medical Traumatic Stress and Trauma-Informed Care in Pediatric Chronic Illness: A Healthcare Provider Survey DOI Creative Commons
Addison A. Cuneo,

Christopher Sifflet,

Naomi S. Bardach

et al.

The Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 261, P. 113580 - 113580

Published: June 21, 2023

To inform approaches to pediatric medical traumatic stress (PMTS) by exploring providers' (1) perception of the impact PMTS on care patients with pediatric-onset chronic illnesses, (2) self-reported competencies and practices prevention, treatment, counseling, (3) barriers influencing adoption these practices.A convenience sample multidisciplinary healthcare providers was recruited through a multimodal recruitment strategy participate in an electronic survey adapted from Trauma-Informed Care Provider Survey.Among participants (n = 304), 99% agreed that impacts patient health. Participants report altering plans due PMTS, including deferring or stopping treatments 98 [32%]) changing medication regimens 88 [29%]). Sixty-eight percent 208) negative implementation plans, nonadherence 153 [50%]) missed appointments 119 [39%]). Although it is their job decrease 292 [96%]) perform assessments 268 [88%]), few practiced PMTS-focused trauma informed care. Systems-level practice included insufficient training, absent clinical workflows, lack access mental health experts.Our findings have helped conceptual framework for understanding relationship between outcomes. opportunities optimize trauma-informed include dissemination provider integrated workflows mitigation, enhanced accessibility providers. Further work required determine if interventions can improve outcomes illnesses.

Language: Английский

Citations

7
Posttraumatic stress and medication adherence in pediatric transplant recipients DOI
Sarah Duncan-Park, Lara Danziger‐Isakov,

Brian Armstrong

et al.

American Journal of Transplantation, Journal Year: 2021, Volume and Issue: 22(3), P. 937 - 946

Published: Nov. 27, 2021

Language: Английский

Citations

16
Pediatric Medical Traumatic Stress in Inflammatory Bowel Disease, Pancreatitis, and Cystic Fibrosis DOI
Addison A. Cuneo, Maisam Abu‐El‐Haija, Meghan L. Marsac

et al.

Journal of Pediatric Gastroenterology and Nutrition, Journal Year: 2022, Volume and Issue: 75(4), P. 455 - 461

Published: July 25, 2022

Objectives: Known as pediatric medical traumatic stress (PMTS), posttraumatic symptoms from experiences have not been explored in children with chronic gastrointestinal diseases. This cross-sectional study of and adolescents inflammatory bowel disease, pancreatitis cystic fibrosis, aimed to (1) estimate the prevalence potentially events (PTEs) PMTS, (2) explore potential risk factors for (3) consequences PMTS. Methods: used validated, self-report measures evaluate PTEs Descriptive statistics regression analyses were achieve objectives. Results: Over two-thirds reported a event (91 132, 69%). Forty-eight had PMTS (36%). was associated medication burden, emergency intensive care visits, parent disorder multivariate analysis. Potential included school absenteeism, home opioid use, poor quality life, missed work. Conclusions: A substantial portion our cohort The exploratory analysis identified associations between illness factors, disorder, functional impairments. Further studies detection, prevention treatment are integral optimizing these children’s health life.

Language: Английский

Citations

12
Examining the association of medical complications and posttraumatic stress symptoms in pediatric solid organ transplant patients and their caregivers DOI
Saba S. Masood, Kelli N. Triplett, Michael Killian

et al.

Pediatric Transplantation, Journal Year: 2021, Volume and Issue: 25(6)

Published: June 2, 2021

Post-traumatic stress symptoms (PTSS) have been reported by pediatric solid organ transplant (SOT) patients and their caregivers well after transplantation. This study examined the relationship between PTSS, medication adherence, medical complications in SOT caregivers. A secondary aim association patient caregiver-reported PTSS.Pediatric (N = 69) 73) on PTSS completing Child PTSD Symptom Scale (patients 8-17 years) or Impact of Events Scale-Revised 18 years older caregivers). Patient adherence was assessed using Medication Level Variability Index (MLVI). Patients were dichotomized as experiencing a post-transplant complication (ie, transplant-related hospital admission prior to year measures PTSS) no complications.Medication not significantly associated with caregiver PTSS. moderate effect size found for elevated young adult presence complication. Generally, self-reported low.The may be partially explained proximal more so comorbid psychiatric diagnoses child adolescent (based exploratory analyses). Caregivers within past higher levels Overall, transplantation its impact unique experience versus Qualitative research further elucidate these experiences inform future clinical interventions.

Language: Английский

Citations

12
Psychological Health of the Adolescent Transplant Recipient DOI
Beth A. Logan,

Imari‐Ashley Isaksen,

Chase Samsel

et al.

Pediatric Transplantation, Journal Year: 2024, Volume and Issue: 28(6)

Published: Aug. 12, 2024

Solid organ transplant recipients experience a period of unique vulnerability during adolescence, when normative developmental changes intersect with health-related variables to influence psychological health.

Language: Английский

Citations

1
Posttraumatic Growth in Youth, Young Adults, and Caregivers Who Experienced Solid Organ Transplant DOI
Kelli N. Triplett, Gillian Mayersohn, Saba S. Masood

et al.

Journal of Pediatric Psychology, Journal Year: 2021, Volume and Issue: 47(9), P. 965 - 977

Published: Dec. 18, 2021

To explore posttraumatic growth (PTG) in pediatric patients who have undergone solid organ transplant (SOT) and their caregivers, to examine potential correlates of PTG.Youth young adults with a history SOT (heart, kidney, liver) at least 1 month prior participation caregivers completed measures PTG, demographic, medical factors. In total, 59 youth (M = 12.68 years, SD 1.91), 21 19.37, 0.82), 95 37.95 9.37) participated.Overall, 67% youth, 76% adults, 89% reported PTG within the medium very high range. Appreciation Life was highest subscale across all groups. Youth caregiver scores were significantly positively correlated. Religious affiliation religious coping associated for relationship yielded large effect sizes adults. Caregivers children kidney transplants endorsed lower than other types had an acute condition greater chronic illness.Findings suggest experience can yield positive changes such as appreciation life. Although small sample may led reduced power detecting significant findings some analyses, results religious, medical, parent-child factors are likely related warrant future investigation.

Language: Английский

Citations

10
Depression in transplantation DOI
Paula C. Zimbrean

Current Opinion in Organ Transplantation, Journal Year: 2022, Volume and Issue: 27(6), P. 535 - 545

Published: Oct. 13, 2022

Purpose of review To and summarize the literature published between 1 January 2020 30 June 2022, on prevalence, risk factors impact depression in transplant population. Recent findings Depression is common transplantation candidates recipients, with a prevalence up to 85.8% kidney recipients. Multiple studies have indicated after correlates increased mortality higher healthcare utilization. Social for posttransplant include financial difficulties unemployment, while less understood about biological substrate this There evidence that dynamic psychotherapy effective organ cognitive behavioral therapy or supportive did not lead improvement For living donors, rates are similar general population, clinical status recipient playing significant role. Summary finding More research needed understand develop treatment interventions.

Language: Английский

Citations

6