International Journal of One Health,
Journal Year:
2025,
Volume and Issue:
unknown, P. 34 - 53
Published: March 1, 2025
Background
and
Aim:
Antimicrobial
resistance
(AMR)
has
emerged
as
one
of
the
most
critical
global
health
challenges
poses
significant
threats
to
human,
animal,
environmental
health.
Indonesia,
like
many
other
developing
nations,
is
facing
widespread
AMR
because
overuse
misuse
antibiotics
in
humans,
livestock,
aquaculture,
agriculture.
The
interconnected
nature
requires
a
holistic
approach
understand
its
prevalence,
pathways,
impact.
A
One
Health
perspective,
which
integrates
health,
vital
for
comprehensively
effectively
addressing
AMR.
This
study
it
provides
detailed
analysis
Indonesia
identifies
patterns
across
various
bacterial
species
antibiotics.
highlights
reservoirs
resistance,
such
wastewater
food-producing
animals,
serve
major
pathways
spread
resistant
genes.
Furthermore,
this
examines
policy
landscape
emphasizing
need
data-driven
interventions
multi-sectoral
collaboration.
offers
insights
into
AMR’s
economic,
social
implications
aligns
with
national
mitigation
frameworks.
primary
aim
was
evaluate
current
state
focusing
on
environmental,
human
sectors.
key
patterns,
transmission
contributing
factors.
In
addition,
proposes
research
roadmap
guide
future
initiatives,
development
rapid
diagnostics,
therapeutic
innovations,
improved
surveillance
systems
combat
growing
threat
Indonesia.
Keywords:
antibiotic
antimicrobial
environment,
policy.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19425 - e19425
Published: May 13, 2025
Tilapia
aquaculture
faces
significant
threats
posed
by
four
prominent
pathogens:
tilapia
lake
virus
(TiLV),
infectious
spleen
and
kidney
necrosis
(ISKNV),
Francisella
orientalis,
Streptococcus
agalactiae.
Currently,
employed
molecular
diagnostic
methods
for
these
pathogens
rely
on
multiple
singleplex
polymerase
chain
reactions
(PCR),
which
are
time-consuming
expensive.
In
this
study,
we
present
an
approach
utilizing
a
multiplex
PCR
(mPCR)
assay,
coupled
with
rapid
Nanopore
sequencing,
enabling
the
one-tube
simultaneous
detection
one-reaction
sequencing-based
validation
of
pathogens.
Our
assay
exhibits
limit
1,000
copies
per
reaction
TiLV,
ISKNV,
S.
agalactiae,
while
F.
is
10,000
reaction.
This
sensitivity
sufficient
diagnosing
infections
co-infections
in
clinical
samples
from
sick
fish,
confirmation
presence
Integrating
sequencing
provides
alternative
platform
fast
precise
diagnostics
major
clinically
animals,
adding
to
available
toolbox
disease
diagnostics.
Fish & Shellfish Immunology,
Journal Year:
2024,
Volume and Issue:
149, P. 109613 - 109613
Published: May 6, 2024
Aporocotylids
(Trematoda:
Digenea),
also
known
as
fish
blood
flukes
infect
the
circulatory
system
of
leading
to
serious
health
problems
and
mortality.
are
a
particular
concern
for
farmed
infection
intensity
can
increase
within
farming
environment
lead
mortalities.
In
context
managing
these
infections,
one
most
crucial
aspects
consider
is
host
response
infected
against
flukes.
Understanding
essential
improving
current
treatment
strategies
that
largely
based
on
use
anthelmintic
praziquantel
manage
infections
in
aquaculture.
This
review
focuses
knowledge
responses
different
life
stages
aporocotylids.
New
able
provide
protection
reinfections
should
be
long-term
goal
not
possible
without
understanding
interactions
between
parasite.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 17, 2022
Piscirickettsiosis
is
the
most
severe,
persistent,
and
damaging
disease
that
has
affected
Chilean
salmon
industry
since
its
origins
in
1980s.
As
a
preventive
strategy
for
this
disease,
different
vaccines
have
been
developed
used
over
last
30
years.
However,
vaccinated
trout
frequently
die
sea
cages
use
of
antibiotics
still
high
demonstrating
low
efficiency
available
vaccines.
The
reasons
why
fail
so
often
are
debated,
but
it
could
involve
extrinsic
intrinsic
factors.
Among
factors,
mainly
associated
with
chronic
stress,
we
can
distinguish:
1)
biotic
including
coinfection
lice,
sealions
attacks
or
harmful
algal
blooms;
2)
abiotic
oxygen
temperature;
3)
farm-management
factors
overcrowding
chemical
delousing
treatments.
fish-related
host’s
genetic
variability
(species,
population
individual),
sex
age;
pathogen-related
their
ability
to
evade
host
immune
responses;
vaccine-related
immunogenicity
poor
matches
circulating
pathogen
strain.
Based
on
evidence,
order
improve
development
efficacy
against
P.
salmonis
recommend:
a)
Do
not
perform
evaluations
by
intraperitoneal
injection
pathogens
because
they
generate
an
artificial
protective
response,
instead
cohabitation
immersion
challenges
must
be
used;
b)
Evaluate
diversity
strains
field
ensure
good
antigenic
match
vaccines;
c)
Investigate
whether
improved,
e.g.
through
selection,
favor
better
longer
responses
vaccination;
d)
To
reduce
stressful
effects
at
cage
level,
controlling
co-infection
avoiding
fish
overcrowding.
date,
do
know
immunological
mechanisms
which
may
protection.
More
studies
required
identify
what
type
cellular
molecular,
develop
effective
Journal of Fish Diseases,
Journal Year:
2024,
Volume and Issue:
47(8)
Published: May 26, 2024
Asian
seabass,
Lates
calcarifer,
is
an
important
aquatic
species
in
mariculture.
Intensive
farming
of
this
has
faced
episodes
bacterial
diseases,
including
those
due
to
vibriosis,
scale
drop,
and
muscle
necrosis
disease,
big
belly
photobacteriosis,
columnaris,
streptococcosis,
aeromoniasis,
tenacibaculosis.
Vaccination
one
the
most
efficient,
non-antibiotic,
eco-friendly
strategies
for
protecting
fish
against
contributing
aquaculture
expansion
ensuring
food
security.
As
now,
although
numerous
vaccines
have
undergone
laboratory
research,
only
commercially
available
inactivated
vaccine,
suitable
both
immersion
injection
administration,
accessible
preventing
Streptococcus
iniae.
Several
key
challenges
developing
seabass
must
be
addressed,
such
as
current
limited
understanding
immunological
responses
vaccines,
costs
associated
with
vaccine
production,
forms,
routes
application,
how
increase
adoption
by
farmers.
The
future
development
industry,
therefore,
discussed
these
critical
issues
mind.
focus
on
improving
our
immunity,
maternal
immunocompetence,
immune
post-vaccination,
well
tools
assess
effectiveness.
need
alignment
state-of-the-art
technologies
employed
human
terrestrial
animal
healthcare
also
discussed.
This
review
discusses
necessity
providing
locally-produced
autogenous
especially
oral
benefit
small-scale
farmers,
potential
benefits
that
might
extended
through
changes
husbandry
practices
vaccination
broodstock
earlier
life
stages
their
off-spring.
