Difference of post COVID health complications among infection and reinfection patients: a comparative study

International Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 13(3), P. 1033 - 1038

Published: Feb. 28, 2025

Background: The novel coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus emerged as a global pandemic in December 2019, leading to significant health concerns. As progressed, post-recovery manifestations survivors became growing issue. Therefore, this comparative study aimed assess post-COVID complication difference between infection and reinfection patients. Methods: This cross-sectional was conducted department of project research, Dhaka Community Medical College Hospital, Dhaka, Bangladesh, from 2023 2024. In study, we included 244 patients who got their treatment Hospital. Results: found that had higher percentages complications, with pain reported 15% cases. Weakness present 33% 37% mental complications also seen respondents like anxiety accounted for 30% 19% respondents. Depression 12% cases 7% Household factors gender, BMI, religion, marital status, residence, living conditions, smoking habits are significantly associated both Conclusions: occurrence among different. Gender, were differences reinfection.

Language: Английский

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Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 21, 2025

Abstract The COVID-19 pandemic has caused at least 780 million cases globally. While available treatments and vaccines have reduced the mortality rate, spread evolution of virus are ongoing processes. Despite extensive research, long-term impact SARS-CoV-2 infection is still poorly understood requires further investigation. Routine analysis provides limited access to tissues patients, necessitating alternative approaches investigate viral dissemination in organism. We address this issue by implementing a whole-body vivo imaging strategy longitudinally assess biodistribution SARS-CoV-2. demonstrate non-human primate model that single injection radiolabeled [ 89 Zr]COVA1-27-DFO human monoclonal antibody targeting preserved epitope spike protein allows longitudinal tracking positron emission tomography with computed (PET/CT). Convalescent animals exhibit persistent PET signal lungs, as well brain, three months following infection. This approach also detection various organs, including airways kidneys, exposed during acute phase. Overall, technology we developed offers comprehensive assessment distribution promising for non-invasive study long-COVID pathophysiology.

Language: Английский

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ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology

Frontiers in Molecular Biosciences, Journal Year: 2021, Volume and Issue: 8

Published: Sept. 21, 2021

The 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered coronavirus. Although generally most noticeable symptoms are concentrated in lungs, disorders gastrointestinal tract of great importance diagnosis 2019-nCoV. angiotensin-converting enzyme 2 (ACE2), an important regulator many physiological functions, including blood pressure and nutrients absorption, identified as vital entry for to enter host cells. In this review, we summarize its functions both physiologically pathologically. We also elaborate conflicting roles from clews contemporary researches, which may provide significant indications pharmacological investigations clinical uses.

Language: Английский

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Pulmonary surfactant and COVID-19: A new synthesis

QRB Discovery, Journal Year: 2022, Volume and Issue: 3

Published: Jan. 1, 2022

COVID-19 pathogenesis poses paradoxes difficult to explain with traditional physiology. For instance, since type II pneumocytes are considered the primary cellular target of SARS-CoV-2; as these produce pulmonary surfactant (PS), possibility that insufficient PS plays a role in has been raised. However, opposite predicted high alveolar surface tension is found many early patients: paradoxically normal lung volumes and compliance occur, profound hypoxemia. That 'COVID anomaly' was quickly rationalised by invoking vascular mechanisms-mainly because surprisingly preserved hypoxemic cases. quick rejection damage only occurred actual mechanism gas exchange long presumed be non-problematic, due diffusion through surface. On contrary, we provide physical chemical evidence occurs an process expansion contraction three-dimensional structures its associated proteins. This view explains anomalous observations from level cryo-TEM whole individuals. It encompasses results premature infants deepest diving seals. Once understood, COVID anomaly dissolves straightforwardly explained covert viral 3D structure PS, direct treatment implications. As natural experiment, SARS-CoV-2 virus itself helped us simplify clarify not nature dyspnea relationship compliance, but also fine detail including such features water channels which had heretofore entirely unexpected.For time, physical, colloid chemistry have intersected physiology cell biology much might hoped. The reasons starting become clear. discipline suffered serious unrecognised omissions rendered it ineffective. These foundational defects included omission specific ion molecular forces hydration effects. lacked predictive theory self-assembly lipids Worse, omitted any for dissolved gases, O2, N2, CO2, their existence stable nanobubbles above physiological salt concentration. Recent developments gone some way explaining foam-like function. delivers O2/N2 nanobubbles, efflux H2O at Knowledge allows explanation corona entry, differences infectivity different variants. CO2 resulting metabolism passing frit provided glycocalyx venous tissue, forms previously unexplained foam endothelial layer. turn out lethal viruses, providing plausible origin 'Long COVID'. Circulating 0.17 M drive various enzyme-like activities reactions. Awareness microstructure Pulmonary Surfactant (O2/N2) integral respiratory circulatory provides new insights other pathogen activity.

Language: Английский

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The Entero-Mammary Pathway and Perinatal Transmission of Gut Microbiota and SARS-CoV-2

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10306 - 10306

Published: Sept. 7, 2022

COVID-19 is a severe respiratory disease threatening pregnant women, which increases the possibility of adverse pregnancy outcomes. Several recent studies have demonstrated ability SARS-CoV-2 to infect mother enterocytes, disturbing gut microbiota diversity. The aim this study was characterize entero-mammary women in presence virus during delivery. Fifty mother−neonate pairs were included transversal descriptive work. RNA detected nasopharyngeal, rectal swabs (MRS) and neonate (NRS) collected from pairs, human colostrum (HC) samples mothers. diversity characterized by high-throughput DNA sequencing V3-16S rRNA gene libraries prepared HC, MRS, NRS. Data analyzed with QIIME2 R. Our results indicate that several bacterial taxa are highly abundant MRS positive for RNA. These bacteria mostly belong Firmicutes phylum; instance, families Bifidobacteriaceae, Oscillospiraceae, Microbacteriaceae been previously associated anti-inflammatory effects, could explain capability overcome infection. All samples, both negative SARS-CoV-2, featured high abundance phylum. Further data analysis showed nearly 20% found HC also identified MRS. Spearman correlation highlighted some genera Proteobacteria Actinobacteria phyla negatively correlated NRS (p < 0.005). This provides new insights into their potential association better outcome

Language: Английский

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Inhaled corticosteroids for the treatment of COVID-19

European Respiratory Review, Journal Year: 2022, Volume and Issue: 31(166), P. 220099 - 220099

Published: Nov. 29, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused illness and mortality for millions worldwide. Despite the development, approval rollout of vaccination programmes globally to prevent infection by SARS-CoV-2 development disease 2019 (COVID-19), treatments are still urgently needed improve outcomes. Early in it was observed that patients with pre-existing asthma or COPD were underrepresented among those COVID-19. Evidence from clinical studies indicates inhaled corticosteroids (ICS) routinely taken could have had a protective role preventing COVID-19 and, therefore, may be promising treatment This review summarises evidence supporting beneficial effects ICS on outcomes explores potential mechanisms.

Language: Английский

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The Theory of Self-Regulation of Parasitary Systems and COVID-19

Annals of the Russian academy of medical sciences, Journal Year: 2024, Volume and Issue: 79(1), P. 33 - 41

Published: Feb. 29, 2024

Background. The COVID-19 pandemic once again confirmed the correctness of theory Academician V.D. Belyakov, according to which basis for development epidemic process is a phase change in heterogeneity biological properties interacting populations pathogen and humans. In accordance with self-regulation parasitic systems, changes are associated not only genetic variability, but also other polydeterminant characteristics pathogen: when new genovariants appeared, SARS-CoV-2 became less pathogenic humans, more contagious. This circumstance important theoretical, practical epidemiology, as it makes possible predict direction situation. Aims — evaluate manifestations coronavirus infection through prism systems. Methods. An epidemiological retrospective analysis incidence was carried out, including study absolute intensive rates per 100,000 population, dynamics identification period from 03.2020 04.2023. To analyze at various stages pandemic, we used sequencing data presented on genome information aggregation platform Virus Genome Aggregator Russia (VGARus) than 248 thousand sequences. Results. During there have been seven ups downs COVID-19. circulation human population adaptation host, significant amount has accumulated evolutionary genome, taking into account trends acquisition properties. Conclusion. COVID-19, classic aerosol anthroponosis, its based negative feedback self-regulation.

Language: Английский

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Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges

PLoS Pathogens, Journal Year: 2021, Volume and Issue: 17(12), P. e1010106 - e1010106

Published: Dec. 30, 2021

The development of safe and effective vaccines in a record time after the emergence Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is remarkable achievement, partly based on experience gained from multiple viral outbreaks past decades. However, Disease 2019 (COVID-19) crisis also revealed weaknesses global pandemic response large gaps that remain our knowledge biology coronaviruses (CoVs) influenza viruses, major respiratory viruses with potential. Here, we review current knowns unknowns CoVs, highlight common research challenges they pose 3 areas: mechanisms adaptation to humans, physiological molecular determinants disease severity, control strategies. We outline multidisciplinary approaches technological innovations need be harnessed order improve preparedeness next pandemic.

Language: Английский

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Autoantibodies against angiotensin‐converting enzyme 2 (ACE2) after COVID‐19 infection or vaccination

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(12)

Published: Dec. 1, 2023

Abstract Autoantibodies against angiotensin‐converting enzyme 2 (ACE2) are frequently reported in patients during coronavirus disease 2019 (COVID‐19) with evidence for a pathogenic role severe infection. However, little is known of the prevalence or clinical significance ACE2 autoantibodies late convalescence following COVID‐19 vaccination. In this study, we measured cohort 182 convalescent patients, 186 vaccine recipients, and 43 adolescents post‐mRNA myopericarditis using two enzymatic immunoassays (EIAs). IgM autoantibody EIA median optical densities (ODs) were lower than pre‐COVID‐19 control samples only 2/182 (1.1%) convalescents testing positive. Similarly, 3/182 (1.6%) tested positive IgG, but history moderate‐severe tended to have significantly higher ODs controls mild patients. contrast, IgG antibodies detected 10/186 (5.4%) recipients after doses Median irrespective platform used (inactivated mRNA). not correlated surrogate neutralizing antibody levels recipients. peaked at day 56 post‐first dose declined within 12 months baseline Presence was associated adverse events immunization including myopericarditis. One patient developed Guillain−Barre syndrome, causality established. observed likely innocuous.

Language: Английский

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The most common skin symptoms in young adults and adults related to SARS-CoV-2 virus infection

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(6)

Published: May 31, 2024

Abstract Scientists from various areas of the world indicate in their studies that skin lesions occur course infection with SARS-CoV-2 virus. This article is a review most frequently described cutaneous manifestations virus and potential pathophysiology development, as well information on abnormalities histopathological tests. The describes impact some factors related to COVID-19 pandemic exacerbation chronic dermatological diseases. work was constructed basis 142 research studies, reviews, meta-analyses, focusing methods materials used individual works results conclusions resulting them. Some may be prognostic marker disease also prodromal symptom or only infection. Stress exacerbate A correlation observed between type patient’s age. occurrence diseases influenced by drugs treat infections caused SARS-CoV-2. relationship ethnic origin occurring COVID-19. There need further diagnose learn detailed pathomechanism order better understand essence find an appropriate treatment method.

Language: Английский

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