S2k-Leitlinie Lebertransplantation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV)

Zeitschrift für Gastroenterologie, Journal Year: 2024, Volume and Issue: 62(09), P. 1397 - 1573

Published: Sept. 1, 2024

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The Impact and Evolution of COVID-19 on Liver Transplant Recipients Throughout the Pandemic “Waves” in a Single Center

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 273 - 273

Published: Feb. 16, 2025

Liver transplant recipients (LTRs) have been considered a population group that is vulnerable to COVID-19 as they are chronically immunosuppressed patients with frequent comorbidities. This study describes the course of SARS-CoV-2 disease from February 2020 December 2023 along seven pandemic "waves". We carried out an observational on 307 cases in cohort LTRs aim evaluating changes characteristics over time and determining risk factors for severe COVID-19. An older age serum creatinine level ≥ 2 mg/dL were found be hospital admission respiratory failure. The use calcineurin inhibitors was protective factor death, hospitalization, failure One hundred percent who died (N = 12) mycophenolate mofetil, which determinant Azathioprine associated intensive care unit (ICU) invasive mechanical ventilation (IMV). Vaccination failure, mortality. rate higher during first five waves, peak 57.14%, highest mortality (21.43%) occurred fourth wave. IMV ICU rates did not show significant differences across periods studied.

Language: Английский

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Minimizing risk while maximizing opportunity: The infectious disease organ offer process survey

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(5)

Published: July 22, 2024

The purpose of this study was to understand how transplant infectious disease (TID) physicians assess a potential donor with known or suspected infection and describe posttransplant management.

Language: Английский

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Favorable experience of transplant strategy including liver grafts from COVID‐19 donors: One‐year follow‐up results

Transplant Infectious Disease, Journal Year: 2023, Volume and Issue: 25(5)

Published: Aug. 16, 2023

Since November 2020, Italy was the first country to carry out a protocol and use liver from COVID-19 donors. We aimed evaluate medium-term outcome of patients who underwent transplant (LT) with those grafts.We consecutively enrolled 283 LT 2020 December 2022 in our Center (follow-up 468 days). Twenty-five (8.8%, study population) received graft donors previous (4%) or active (96%) SARS-CoV-2 infection, 258/283 (91.2%, control group) COVID-19-negative SARS-CoV-2-RNA tested on tissue their recipients weekly evaluation nasal swabs for month after LT.One-year 2-year patient survival 88.5% group versus 94.5% 93.5% group, respectively (p = .531). In population there no evidence donor-recipient virus transmission, but three (12%) (vs. 7 [2.7%] p .048) developed hepatic artery thrombosis (HAT): they were negative at 1/3 grafts positive tissue. donor independently associated HAT (odds ratio (OR) 4.85, 95% confidence interval (CI) 1.10-19.15; .037). By comparing acute rejection biliary complication rates not significantly different (16% vs. 8.1%, .26; 16% 16.3% .99, respectively).Our 1-year results strategy including favorable. only higher rate transplanted compared group.

Language: Английский

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Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management

Transplant International, Journal Year: 2024, Volume and Issue: 37

Published: Oct. 2, 2024

Expected and unexpected donor-derived infections are a rare complication of solid organ transplantation, but can result in significant morbidity mortality. Over the last years, growing gap existing between patients on waiting list available organs has favored use from donors with suspected or confirmed infections, thanks to improvement risk mitigation strategies against transmission well recognized emerging infections. Given recent developments, particular interest this review is summarize data how maximize utilization HIV+ recipients, HCV-viremic HBV positive donors. This article also covers implications for recipient bacteremia challenge multidrug resistant (MDR) Lastly describes risks associated Coronavirus Disease-2019 (COVID-19) pandemics.

Language: Английский

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Acceptance of Organs from Deceased Donors With Resolved or Active SARS-CoV-2 Infection: A Survey From the Council of Europe

Transplant International, Journal Year: 2024, Volume and Issue: 37

Published: Nov. 21, 2024

SARS-CoV-2 infection represents a new challenge for solid organ transplantation (SOT) with evolving recommendations. A cross-sectional survey was performed (February-June 2024) to describe practices among Member States of the Council Europe (COE) on use organs from deceased donors resolved or active infection. Overall, 32 out 47 transplant program participated in study. Four (12.5%) countries did not either and 8 (25%) accepted only Donor evaluation included universal screening standard PCR testing respiratory specimens generally (61.4%) within 24 h prior recovery. Further microbiological, immunological radiological investigations varied. Most waitlisted patients receiving donor (94.5%) (61.5%) were preferred have natural, vaccine-induced hybrid immunity. require recipients undergo specific anti-SARS-CoV-2 treatment as pre-exposure (0%), post-exposure prophylaxis (15.4%) modification immunosuppression regimen (24%). This study highlights similarities heterogeneities management positive between COE countries, potential safely expand donors' pool.

Language: Английский

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Recommendations for SARS-CoV-2 testing and organ procurement from deceased donors in the Republic of Korea

Korean Journal of Transplantation, Journal Year: 2023, Volume and Issue: 37(3), P. 145 - 154

Published: Aug. 24, 2023

Si-Ho Kim, Yu Mi Wi, Chisook Moon, Ji-Man Kang, Minhwa Jungok Jong Man Hyeri Seok, Hye Jin Shi, Su Lee, Ji Yeon Jeong, Pyoeng Gyun Choe, Kyungmin Huh, Sang-Oh Sang Il Kim; Transplant Infection Research Committee of the Korean Society Infectious Diseases. J -0001;0:. https://doi.org/10.4285/kjt.23.0034

Language: Английский

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Therapeutic strategy in the transplanted patient

Revista Española de Quimioterapia, Journal Year: 2023, Volume and Issue: 36(Suppl1), P. 18 - 21

Published: Nov. 24, 2023

The SARS-CoV-2 infection prognosis has dramatically changed as a result of population vaccination and the surge omicron. However, there are still specific populations at risk progression to severe diseases that require hospitalization or even death. kidney transplant is one them. Consequently, when compatible symptoms appear, an early diagnosis should be sought in order start antiviral treatment soon possible avoid clinical deterioration patient. Antivirals have shown, patients, decrease rate death, especially with their administration.

Language: Английский

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Severe acute respiratory syndrome coronavirus 2 positive donors: Improving utilization

Transplant Infectious Disease, Journal Year: 2023, Volume and Issue: 25(1)

Published: Jan. 19, 2023

The authors declare that they have no conflict of interest. These data were derived from the following resources available in public domain: (SRTR, PubMed)

Language: Английский

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