Colloidal Self-Assembly Approaches to Smart Nanostructured Materials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(5), P. 4976 - 5067

Published: Nov. 8, 2021

Colloidal self-assembly refers to a solution-processed assembly of nanometer-/micrometer-sized, well-dispersed particles into secondary structures, whose collective properties are controlled by not only nanoparticle property but also the superstructure symmetry, orientation, phase, and dimension. This combination characteristics makes colloidal superstructures highly susceptible remote stimuli or local environmental changes, representing prominent platform for developing stimuli-responsive materials smart devices. Chemists achieving even more delicate control over their active responses various practical stimuli, setting stage ready fully exploiting potential this unique set materials. review addresses colloids nanostructured We first delineate driven forces different length scales. A concepts equations outlined controlling crystal growth, appreciating importance particle connectivity in creating responsive superstructures. then present working mechanisms strategies engineering assemblies. The underpinning separation systematically introduced, allowing tuning precise prediction response external stimuli. Various exciting applications these summarized with specific focus on structure-property correlation functional conclude summary existing challenges provide perspective further advances next generation.

Language: Английский

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Recent advances in selective photothermal therapy of tumor

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Oct. 24, 2021

Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways improve the efficiency of tumor ablation treat cancer, PTT may cause severe damage normal tissue due systemic distribution photothermal agents (PTAs) body and inaccurate laser exposure during To further survival rate patients reduce possible side effects on other parts body, it is still necessary explore PTAs with high selectivity precise In this review, we summarized strategies treatment PTT, such as increasing accumulation at sites endowing self-regulating conversion function. The views challenges selective were discussed, especially prospects their clinical applications.

Language: Английский

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Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

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Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(36)

Published: July 23, 2021

Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small-molecule immunomodulators lead the off-target adverse effects insufficient therapeutic outcomes. Herein a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of reported. ASPA backbone obtained by conjugating vipadenant, an antagonist adenosine A2A receptor, onto NIR-II light-absorbing polymer via azo-based thermolabile linker. Under deep-penetrating photoirradiation, induces tumor thermal ablation subsequently immunogenic cell death, triggers cleavage linker, releases block adenosinergic pathway. Such remotely controlled regulation potentiates cytotoxic T functions while suppresses regulatory activities, leading efficient primary inhibition, pulmonary metastasis prevention, long-term immunological memory. Thereby, this work provides generic approach precise spatiotemporal immunometabolism.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Plasmonic silver and gold nanoparticles: shape- and structure-modulated plasmonic functionality for point-of-caring sensing, bio-imaging and medical therapy

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(6), P. 2932 - 2971

Published: Jan. 1, 2024

Silver and gold nanoparticles have found extensive biomedical applications due to their strong localized surface plasmon resonance (LSPR) intriguing plasmonic properties. This review article focuses on the correlation among particle geometry, properties applications. It discusses how shape size are tailored

Language: Английский

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Sensitive Activatable Nanoprobes for Real‐Time Ratiometric Magnetic Resonance Imaging of Reactive Oxygen Species and Ameliorating Inflammation In Vivo

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(19)

Published: March 11, 2022

Imaging-guided real-time monitoring of the treatment process inflammatory diseases is important for timely adjustment planning to lower unnecessary side effects and improve outcomes. However, it difficult reflect dynamic changes inflammation in vivo with enough tissue penetration depth. Here a novel nanotheranostic agent (denominated TMSN@PM) platelet membrane (PM)-coated, tempol-grafted, manganese-doped, mesoporous silica nanoparticles developed. The PM endows TMSN@PM ability target sites, which are verified by fluorescence imaging Cyanine5 carboxylic acid (Cy5)-labeled TMSN@PM. Under environment (mild acidity excess reactive oxygen species (ROS)), can scavenge ROS, thereby alleviating inflammation, degrade, release manganese ions enhanced magnetic resonance (MRI). relaxation (ΔR1 ) almost linearly correlated concentration H2 O2 , degree inflammation. This method offers non-invasive imaging-based strategy early prediction therapeutic outcomes therapy, may contribute precision medicine terms prognostic stratification future.

Language: Английский

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Smart PdH@MnO₂ Yolk–Shell Nanostructures for Spatiotemporally Synchronous Targeted Hydrogen Delivery and Oxygen-Elevated Phototherapy of Melanoma

ACS Nano, Journal Year: 2022, Volume and Issue: 16(4), P. 5597 - 5614

Published: March 22, 2022

Hydrogen therapy, an emerging therapeutic strategy, has recently attracted much attention in anticancer medicine. Evidence suggests that hydrogen (H2) can selectively reduce intratumoral overexpressed hydroxyl radicals (•OH) to break the redox homeostasis and thereby lead stress cell damage. However, inability achieve stable storage efficient delivery hinders development of therapy. Furthermore, oxygen (O2) deficiency tumor microenvironment (TME) electron-hole separation inefficiency photosensitizers have severely limited efficacy photodynamic therapy (PDT). Herein, a smart PdH@MnO2/Ce6@HA (PHMCH) yolk-shell nanoplatform is designed surmount these challenges. PdH tetrahedrons combine high photothermal conversion efficiency palladium (Pd) nanomaterials with near-infrared-controlled release. Subsequently, narrow bandgap semiconductor manganese dioxide (MnO2) photosensitizer chlorin e6 (Ce6) are introduced into PHMCH nanoplatform. Upon irradiation, staggered energy band edges heterogeneous materials composed MnO2 Ce6 efficiently facilitate for increasing singlet (1O2). Moreover, nanoshells generate O2 TME ameliorating hypoxia further improving O2-dependent PDT. Finally, hyaluronic acid-modified shows negligible cytotoxicity targets CD44-overexpressing melanoma cells. The synergistic antitumor performance H2-mediated gas combined enhanced PDT explore more possibilities design gas-mediated cancer

Language: Английский

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An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(29)

Published: May 24, 2022

Hypoxia, as a characteristic feature of solid tumors, has close relationship with tumor resistance to photodynamic therapy (PDT) and chemotherapy. Perfluorocarbon (PFC) is reported relieve hypoxic in tumors by acting an oxygen carrier via several nanostructures. However, the delivery process mostly driven concentration gradient, which uncontrollable. Herein, photothermally controlled "oxygen bomb" PSPP-Au980 -D designed encapsulating PFC core within functionalized bilayer polymer shell. Near-infrared second window photothermal agent gold nanorods excellent photo-to-heat energy-conversion ability are fabricated on surface shell innovative modified two-step seedless ex situ growth thermally trigger O2 release. Then, programmed cascade strategy customized for orthotopic pancreatic cancer. First, irradiated 980 nm laser infusing into microenvironment, accompanied local hyperemia doxorubicin Subsequently, 680 used generate singlet oxygenated microenvironment PDT. This choreographed will provide new route suppressing under mild conditions based controllable effective

Language: Английский

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Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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