Emerging Modalities and Implantable Technologies for Neuromodulation

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 115 - 135

Published: March 26, 2020

Language: Английский

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Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 6(6), P. 741 - 753

Published: Dec. 16, 2021

Language: Английский

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In Vivo Organic Bioelectronics for Neuromodulation

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(4), P. 4826 - 4846

Published: Jan. 20, 2022

The nervous system poses a grand challenge for integration with modern electronics and the subsequent advances in neurobiology, neuroprosthetics, therapy which would become possible upon such integration. Due to its extreme complexity, multifaceted signaling pathways, ∼1 kHz operating frequency, complementary metal oxide semiconductor (CMOS) based appear be only technology platform at hand However, conventional CMOS-based rely exclusively on electronic therefore require an additional translate signals into language of neurobiology. Organic are just platform, capable converting addressing variety matching endogenous while simultaneously possessing favorable material similarities tissue. In this review, we introduce organic platforms modalities specifically designed role as "translator", focusing especially recent implementation

Language: Английский

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A 3D biomimetic optoelectronic scaffold repairs cranial defects

Science Advances, Journal Year: 2023, Volume and Issue: 9(7)

Published: Feb. 15, 2023

Bone fractures and defects pose serious health-related issues on patients. For clinical therapeutics, synthetic scaffolds have been actively explored to promote critical-sized bone regeneration, electrical stimulations are recognized as an effective auxiliary facilitate the process. Here, we develop a three-dimensional (3D) biomimetic scaffold integrated with thin-film silicon (Si)-based microstructures. This Si-based hybrid not only provides 3D hierarchical structure for guiding cell growth but also regulates behaviors via photo-induced signals. Remotely controlled by infrared illumination, these Si structures electrically modulate membrane potentials intracellular calcium dynamics of stem cells potentiate proliferation differentiation. In rodent model, Si-integrated demonstrates improved osteogenesis under optical stimulations. Such wirelessly powered optoelectronic eliminates tethered implants fully degrades in biological environment. The combines topographical stimuli modulations, offering broad potential biomedicine.

Language: Английский

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Monitoring the Electrochemical Failure of Indium Tin Oxide Electrodes via Operando Ellipsometry Complemented by Electron Microscopy and Spectroscopy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 9517 - 9531

Published: Feb. 7, 2024

Transparent conductive oxides such as indium tin oxide (ITO) are standards for thin film electrodes, providing a synergy of high optical transparency and electrical conductivity. In an electrolytic environment, the determination inert electrochemical potential window is crucial to maintain stable material performance during device operation. We introduce operando ellipsometry, combining cyclic voltammetry (CV) with spectroscopic versatile tool monitor evolution both complete (i.e., complex refractive index) properties under wet operational conditions. particular, we trace degradation ITO electrodes caused by reduction in pH-neutral, water-based electrolyte environment cycling. With onset hydrogen at negative bias voltages, irreversibly reduced metallic state, causing advancing darkening, i.e., gradual loss transparency, every CV cycle, while conductivity mostly conserved over multiple cycles. Post-operando analysis reveals reductive (loss oxygen) formation nanodroplets on surface. The disruption electrode happens solid–liquid interface proceeds gradually from surface bottom layer, which evidenced cross-sectional transmission electron microscopy imaging complemented energy-dispersive X-ray spectroscopy mapping. As long continuous part layer remains bottom, largely retained, allowing repeated consider ellipsometry sensitive nondestructive early stage property changes, either tracing failure points, controlling intentional processes, or sensing purposes, making it suitable various research fields involving interfaces activity.

Language: Английский

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Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 5, 2024

Abstract Electrical stimulation is a fundamental tool in studying neural circuits, treating neurological diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric particle systems have emerged as non-genetic wireless alternatives for electrode-based tethered systems. However, achieving cell-specific high-frequency remains challenging due to high-intensity thresholds, non-specific diffusion, internalization of particles. Here, we develop cell-sized 20 μm-diameter silica-based magnetic Janus microparticles (PEMPs), enabling clinically-relevant primary neurons under low-intensity focused ultrasound. Owing its functionally anisotropic design, half the PEMP acts electrode via conjugated barium titanate nanoparticles induce electrical stimulation, while nickel-gold nanofilm-coated provides spatial orientational control on external uniform rotating fields. Furthermore, surface functionalization with targeting antibodies enables binding/targeting dopaminergic neurons. Taking advantage such functionalities, design offers unique features towards minimally invasive treatment diseases.

Language: Английский

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Bioinspired Ionic Sensory Systems: The Successor of Electronics

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(31)

Published: June 5, 2020

Abstract All biological systems, including animals and plants, communicate in a language of ions small molecules, while the modern information infrastructures technologies rely on electrons. Although electronics bioelectronics have made great progress past several decades, they still face disadvantage signal transformation when communicating with biology. To narrow gap between systems artificial‐intelligence bioinspired ion‐transport‐based sensory should be developed as successor electronics, since can emulate functionality more directly biology seamlessly. Herein, essential principles (accurate) ion transport are introduced, recent development three elements an ionic system is reviewed: sensors, processors, interfaces. The current challenges future developments also discussed.

Language: Английский

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Recent advances in bioelectronics chemistry

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 7978 - 8035

Published: Jan. 1, 2020

In this review, we focus on the contributions made to bioelectronic field from various aspects of chemistry.

Language: Английский

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Organic Bioelectronics for In Vitro Systems

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(4), P. 4700 - 4790

Published: Dec. 15, 2021

Bioelectronics have made strides in improving clinical diagnostics and precision medicine. The potential of bioelectronics for bidirectional interfacing with biology through continuous, label-free monitoring on one side precise control biological activity the other has extended their application scope to vitro systems. advent microfluidics considerable advances reliability complexity models promise eventually significantly reduce or replace animal studies, currently gold standard drug discovery toxicology testing. are anticipated play a major role this transition offering much needed technology push forward paradigm. Organic electronic materials, notably conjugated polymers, having demonstrated technological maturity fields such as solar cells light emitting diodes given outstanding characteristics versatility processing, obvious route due biomimetic nature, among merits. This review highlights polymers tissue vitro, aiming ultimately develop next generation We showcase across multiple length scales, involving varying complexity, from cell components complex 3D cultures. state art, possibilities, challenges toward translation systems also discussed throughout.

Language: Английский

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Fully Inkjet‐Printed, Ultrathin and Conformable Organic Photovoltaics as Power Source Based on Cross‐Linked PEDOT:PSS Electrodes

Advanced Materials Technologies, Journal Year: 2020, Volume and Issue: 5(8)

Published: June 14, 2020

Abstract Ultra‐lightweight solar cells have attracted enormous attention due to their ultra‐conformability, flexibility, and compatibility with applications including electronic skin or miniaturized electronics for biological applications. With the latest advancements in printing technologies, ultrathin is becoming now a reality. This work offers an easy path fabricate indium tin oxide (ITO)‐free ultra‐lightweight organic through inkjet‐printing while preserving high efficiencies. A method consisting of modification poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) ink methoxysilane‐based cross‐linker (3‐glycidyloxypropyl)trimethoxysilane (GOPS)) presented chemically modify structure electrode layer. Combined plasma solvent post‐treatments, this approach prevents shunts ensures precise patterning cells. By using poly(3‐hexylthiophene) along rhodanine‐benzothiadiazole‐coupled indacenodithiophene (P3HT:O‐IDTBR), power conversion efficiency (PCE) fully printed boosted up 4.73% fill factors approaching 65%. All inkjet‐printed on 1.7 µm thick biocompatible parylene substrate are fabricated PCE reaching 3.6% power‐per‐weight values 6.3 W g −1 . After encapsulation, retain performance after being exposed 6 h aqueous environments such as water, seawater, phosphate buffered saline, paving way integration more complex circuits systems.

Language: Английский

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