Metal–Organic Framework-Based Enzyme Biocomposites

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(3), P. 1077 - 1129

Published: Jan. 13, 2021

Because of their efficiency, selectivity, and environmental sustainability, there are significant opportunities for enzymes in chemical synthesis biotechnology. However, as the three-dimensional active structure is predominantly maintained by weaker noncovalent interactions, thermal, pH, stressors can modify or eliminate activity. Metal–organic frameworks (MOFs), which extended porous network materials assembled a bottom-up building block approach from metal-based nodes organic linkers, be used to afford protection enzymes. The self-assembled structures MOFs encase an enzyme process called encapsulation when MOF synthesized presence biomolecule. Alternatively, infiltrated into mesoporous surface bound via covalent processes. Integration this way affords allows maintain activity challenge conditions (e.g., denaturing agents, elevated temperature, non-native solvents). In addition forming simple enzyme/MOF biocomposites, other introduced composites improve recovery facilitate advanced applications sensing fuel cell technology. This review canvasses encapsulation, pore infiltration, adsorption summarizes strategies form multicomponent composites. Also, given that biocomposites straddle chemistry enzymology, provides assessment characterization methodologies MOF-immobilized identifies some key parameters development field.

Language: Английский

---

Synthesis, characterization and application of defective metal–organic frameworks: current status and perspectives

Journal of Materials Chemistry A, Journal Year: 2020, Volume and Issue: 8(41), P. 21526 - 21546

Published: Jan. 1, 2020

An overview of important recent advances on synthesis, characterization and application defective metal–organic frameworks is provided.

Language: Английский

---

Recent advances in enzyme immobilization based on novel porous framework materials and its applications in biosensing

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 459, P. 214414 - 214414

Published: Feb. 5, 2022

Language: Английский

---

Programmable Logic in Metal–Organic Frameworks for Catalysis

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(46)

Published: May 28, 2021

Abstract Metal–organic frameworks (MOFs) have emerged as one of the most widely investigated materials in catalysis mainly due to their excellent component tunability, high surface area, adjustable pore size, and uniform active sites. However, overwhelming number MOF complex structures has brought difficulties for researchers select construct suitable MOF‐based catalysts. Herein, a programmable design strategy is presented based on metal ions/clusters, organic ligands, modifiers, functional materials, post‐treatment modules, which can be used components, structures, morphologies catalysts different reactions. By establishing corresponding relationship between these modules functions, accurately efficiently heterometallic MOFs, chiral conductive hierarchically porous defective composites, MOF‐derivative Further, this approach also regulate physical/chemical microenvironments pristine heterogeneous catalysis, electrocatalysis, photocatalysis. Finally, challenging issues opportunities future research are discussed. Overall, modular concept review applied potent tool exploring structure–activity relationships accelerating on‐demand multicomponent

Language: Английский

---

Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6824 - 6863

Published: Jan. 1, 2022

This review comprehensively presents the cutting-edge advances of enzyme confinement using different porous organic frameworks.

Language: Английский

---

Towards applications of bioentities@MOFs in biomedicine

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 429, P. 213651 - 213651

Published: Dec. 18, 2020

Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells have emerged as novel biocomposites for application to drug delivery, biosensing, biospecimen preservation, cell virus manipulation. The integration of biological entities into MOF matrices generates functional characteristics that cannot be observed in the separate components, such enhanced chemical thermal stability, resistance proteases, MOF-conferred selectivity, controlled release. In this review, we will discuss these properties applications obtained by encapsulation (i) proteins, (ii) carbohydrates, (iii) nucleic acids, (iv) or a matrix. Finally, review post functionalization MOF-based carriers lipids potential route enhance dispersion, stability fluids, blood circulation time delivery systems.

Language: Английский

---

Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(9), P. 5347 - 5420

Published: April 12, 2023

Enzymatic catalysis has fueled considerable interest from chemists due to its high efficiency and selectivity. However, the structural complexity vulnerability hamper application potentials of enzymes. Driven by practical demand for chemical conversion, there is a long-sought quest bioinspired catalysts reproducing even surpassing functions natural As nanoporous materials with surface areas crystallinity, metal-organic frameworks (MOFs) represent an exquisite case how enzymes their active sites are integrated into porous solids, affording heterogeneous superior stability customizable structures. In this review, we comprehensively summarize advances MOFs catalysis, discuss design principle various MOF-based catalysts, such as MOF-enzyme composites embedded sites, explore utility these in different reactions. The advantages enzyme mimetics also highlighted, including confinement, templating effects, functionality, comparison homogeneous supramolecular catalysts. A perspective provided potential solutions addressing current challenges MOF catalysis.

Language: Английский

---

Micro/nano metal–organic frameworks meet energy chemistry: A review of materials synthesis and applications

eScience, Journal Year: 2023, Volume and Issue: 3(2), P. 100092 - 100092

Published: Jan. 10, 2023

Micro/nano metal–organic frameworks (MOFs) have attracted significant attention in recent years due to their numerous unique properties, with many synthetic methods and strategies being reported for constructing MOFs specific micro/nano structures. In addition, the design of energy storage conversion applications study structure–activity relationship also become research hotspots. Herein, a comprehensive overview progress on is presented. We begin brief introduction various synthesis controlling morphology MOFs. Subsequently, structure-dependent properties as electrode materials or catalysts terms batteries, supercapacitors, catalysis are discussed. Finally, remaining challenges future perspectives this field Overall, review expected inspire advanced efficient technologies.

Language: Английский

---

Microfluidic Nanoparticles for Drug Delivery

Small, Journal Year: 2022, Volume and Issue: 18(36)

Published: April 9, 2022

Abstract Nanoparticles (NPs) have attracted tremendous interest in drug delivery the past decades. Microfluidics offers a promising strategy for making NPs due to its capability precisely controlling NP properties. The recent success of mRNA vaccines using microfluidics represents big milestone microfluidic pharmaceutical applications, and rapid scaling up demonstrates feasibility industrial‐scale manufacturing. This article provides critical review progress delivery. First, synthesis organic focusing on typical methods their applications popular clinically relevant NPs, such as liposomes, lipid polymer well mechanisms are summarized. Then, several representative inorganic (e.g., silica, metal, metal oxide, quantum dots), hybrid is discussed. Lastly, various presented.

Language: Английский

---

The Role of Defects in Metal–Organic Frameworks for Nitrogen Reduction Reaction: When Defects Switch to Features

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(17)

Published: Feb. 22, 2021

Abstract The electrochemical nitrogen reduction reaction (NRR), a contributor for producing ammonia under mild conditions sustainably, has recently attracted global research attention. Thus far, the design of highly efficient electrocatalysts to enhance NRR efficiency is specific focus research. Among them, defect engineering considered significant way improve electrocatalytic by regulating electronic state and providing more active sites that can give better physicochemical properties. Recently, metal–organic frameworks (MOFs), along with their derivatives, have captured immense interest in reactions owing not only large surface area high porosity but also ability create rich defects structures. Hence, they provide plenty exposed electron transfer, NN cleavage, N 2 adsorption performance. Herein, concept, situ characterizations techniques defects, most common ways into MOFs been summarized. Furthermore, recent advances MOF‐based towards recapitulated. Ultimately, major challenges outlook are proposed. This paper anticipated critical guidelines optimizing electrocatalysts.

Language: Английский

---