Apigenin Alleviates Obesity-Associated Metabolic Syndrome by Regulating the Composition of the Gut Microbiome DOI Creative Commons
Yuan Qiao, Zhichun Zhang, Yuanyuan Zhai

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 3, 2022

The gut microbiota, often viewed as a "digestive organ," can influence the development of obesity and related metabolic disorders. Diet is significantly important in shaping structure modulating function microbiota. Apigenin (Api) widely exists fruits vegetables naturally occurring flavonoid has anti-obesogenic, anti-inflammatory, anti-carcinogenic properties. Its low bioavailability means it enough time to interact with intestine thus becomes potential substrate for intestine; thus, contributing health. Here, we show that Api reduces whole-body weight, low-grade inflammation, insulin resistance high-fat diet (HFD)-induced obese mice. Our results reflect supplementation substantially improve intestinal dysbiosis triggered by HFD restores barrier damage alleviating endotoxemia. Augmentation Akkermansia Incertae_Sedis along reduction Faecalibaculum Dubosiella at genus level potentially mediated protective effects on syndrome. Furthermore, impact body weight modification microbiota could be transferred from Api-administered mice HFD-feeding via horizontal fecal transplantation. Taken together, our data highlight prebiotic role its contribution restraint deterioration associated

Language: Английский

Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation DOI Creative Commons

Zheng‐Meng Jiang,

Su-Ling Zeng,

Tianqing Huang

et al.

Science Bulletin, Journal Year: 2023, Volume and Issue: 68(14), P. 1540 - 1555

Published: June 28, 2023

Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA). Sinomenine (SIN) an effective immunosuppressive and anti-inflammatory drug used for treating RA, but how SIN regulates gut to alleviate RA remains underexplored. To identify critical microbial species metabolites RA-protective effects SIN, microbiota-dependent anti-RA were assessed by 16S rRNA gene sequencing, antibiotic treatment, fecal transplantation. Metabolomics analysis, transcriptional targeted bacteria/metabolites gavage conducted explore reduce severity RA. could restore intestinal balance mainly modulating abundance Lactobacillus, significantly relieve collagen-induced (CIA) symptoms in a manner. elevated tryptophan indole-3-acrylic acid (IA), indole-3-propionic (IPA), indole-3-acetic (IAA). Tryptophan supplementation activate aryl hydrocarbon receptor (AhR) regulate Th17/Treg CIA rats. Intriguingly, relieved involving enrichment two beneficial anti-CIA Lactobacillus species, L. paracasei casei mono-colonization. The promising therapeutic function was mostly attributed activation AhR explicitly targeting metabolites. bacterium may be CIA.

Language: Английский

Citations

68
Lachnospiraceae -derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus DOI Creative Commons
Shuangbo Huang, Jianzhao Chen, Zhijuan Cui

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(44)

Published: Nov. 3, 2023

Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus (GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we report association placental inflammation (tumor necrosis factor–α) abnormal maternal glucose metabolism in patients with GDM, high fermentable dietary fiber (HFDF; konjac ) could reduce GDM development through gut flora–short-chain fatty acid–placental axis mouse model. Mechanistically, HFDF increases abundances Lachnospiraceae butyrate, reduces placental-derived by enhancing barrier inhibiting transfer bacterial-derived lipopolysaccharide, ultimately resists high-fat diet–induced resistance. butyrate have similar anti-GDM anti–placental effects, they can ameliorate function pregnancy outcome effects probably dampening immune dysfunction. These findings demonstrate involvement important inflammation–related progression great potential HFDFs to susceptibility gut-flora-placenta axis.

Language: Английский

Citations

50
Associations between dietary flavonoid intake with hepatic steatosis and fibrosis quantified by VCTE: Evidence from NHANES and FNDDS DOI
Ruijie Xie, Ya Zhang

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2023, Volume and Issue: 33(6), P. 1179 - 1189

Published: March 10, 2023

Language: Английский

Citations

44
Polysaccharides from Fu brick tea ameliorate obesity by modulating gut microbiota and gut microbiota-related short chain fatty acid and amino acid metabolism DOI Open Access
Mingzhi Zhu,

Jian Ouyang,

Fang Zhou

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 118, P. 109356 - 109356

Published: April 21, 2023

Language: Английский

Citations

43
Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives DOI Creative Commons
Xiaopeng Li, Enjun Xie,

Shumin Sun

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Flavonoids are naturally occurring dietary phytochemicals with significant antioxidant effects aside from several health benefits. People often consume them in combination other food components. Compiling data establishes a link between bioactive flavonoids and prevention of diseases animal models, including cardiovascular diseases, diabetes, gut dysbiosis, metabolic dysfunction-associated steatotic liver disease (MASLD). However, numerous clinical studies have demonstrated the ineffectiveness contradicting rodent thereby challenging validity using as supplements. This review provides perspective to emphasize effective roles well summarize their specific mechanisms animals briefly. First, this offers an in-depth elucidation processes within human, encompassing small, large intestine, liver. Furthermore, comprehensive overview various functions gastrointestinal tract, hindering breakdown assimilation macronutrients, such polysaccharides lipids, regulating hormone secretion inhibition mineral iron absorption. In unabsorbed major portion interact flora leading biotransformation. Once absorbed circulated bloodstream, or metabolites exert beneficial systemic effects. Lastly, we examine protective disorders, endothelial dysfunction, MASLD, disease, obesity, hyperlipidemia, insulin resistance. conclusion, outlines safety future prospects field health, especially syndrome (MetS).

Language: Английский

Citations

3
Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance DOI Creative Commons
Jan Gojda, Monika Cahová

Biomolecules, Journal Year: 2021, Volume and Issue: 11(10), P. 1414 - 1414

Published: Sept. 28, 2021

The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet major source of are metabolized to end-products, further serving as signal molecules microbiota-host cross-talk. Among these molecules, branched-chain amino acids (BCAAs) gained significant scientific attention. BCAAs abundant animal-based dietary sources; they both produced degraded by microbiota host circulating levels associated risk type 2 diabetes. This review aims summarize current knowledge complex relationship between functional handle well BCAA metabolism insulin resistance development. Targeting modulation could represent promising approach prevention treatment related states, such obesity

Language: Английский

Citations

103
Study on toxicity effects of environmental pollutants based on metabolomics: A review DOI
Li Liu,

Qinchao Wu,

Xinyi Miao

et al.

Chemosphere, Journal Year: 2021, Volume and Issue: 286, P. 131815 - 131815

Published: Aug. 6, 2021

Language: Английский

Citations

100
Involvement of Gut Microbiota, Microbial Metabolites and Interaction with Polyphenol in Host Immunometabolism DOI Open Access
Andy W. C. Man,

Yawen Zhou,

Ning Xia

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(10), P. 3054 - 3054

Published: Oct. 6, 2020

Immunological and metabolic processes are inextricably linked important for maintaining tissue organismal health. Manipulation of cellular metabolism could be beneficial to immunity prevent degenerative diseases including obesity, diabetes, cancer. Maintenance a normal depends on symbiotic consortium gut microbes. Gut microbiota contributes certain xenobiotic metabolisms bioactive metabolites production. microbiota-derived have been shown involved in inflammatory activation macrophages contribute diseases. Recent studies focused how nutrients affect immunometabolism. Polyphenols, the secondary plants, presented many foods beverages. Several demonstrated antioxidant anti-inflammatory properties polyphenols. Many clinical trials epidemiological also that long-term consumption polyphenol-rich diet protects against chronic It is known polyphenols can modulate composition core interact with In present article, we review mechanisms its immunometabolism, summarize recent findings interaction between polyphenol modulates host discuss future research directions.

Language: Английский

Citations

98
Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls DOI Creative Commons
Cassandra E. Gheorghe, Nathaniel L. Ritz, Jason Martin

et al.

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

In recent years, studies investigating the role of gut microbiota in health and diseases have increased enormously – making it essential to deepen question research methodology employed. Fecal transplantation (FMT) rodent (either from human or animal donors) allows us better understand causal intestinal across multiple fields. However, this technique lacks standardization requires careful experimental design order obtain optimal results. By comparing several which rodents are final recipients FMT, we summarize common practices review, document limitations method highlight different parameters be considered while designing FMT Studies. Standardizing is challenging, as differs according topic, but avoiding pitfalls feasible. Several methodological questions remain unanswered day offer a discussion on issues explored future studies.

Language: Английский

Citations

97
Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota DOI Creative Commons
Wenlong Sun, Xinyu Li,

Hao-Yue Dou

et al.

Cell Reports, Journal Year: 2021, Volume and Issue: 36(9), P. 109641 - 109641

Published: Aug. 1, 2021

The relationship between poor in vivo bioavailability and effective pharmacological activity are not yet fully clarified for many flavonoids. analysis of flavonoids-induced alterations the gut microbiota represents a promising approach to provide useful clues elucidate mechanism action. Here, we investigate effect myricetin supplementation on high-fat-diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) rats explore associations with through high-throughput analyses. 12-week fecal transplantation outcomes suggest that significantly slows development NAFLD. Meanwhile, anti-NAFLD effects associated modulation composition. Myricetin reduces hepatic lipid synthesis inflammation modulations butyric-acid-related protection barrier function. This study may facilitate elucidation action flavonoids low bioavailability.

Language: Английский

Citations

81