Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 15, 2025
The
gut
microbial
importance
and
its
crucial
roles
in
host
digestion,
immunity,
metabolism
have
received
widely
attention.
Horses,
especially
indigenous
varieties
such
as
Mongolian
horses
(MGH)
Guizhou
(GZH),
not
sufficient
attention,
the
characteristics
of
their
microbiota
are
still
unclear.
For
this
purpose,
we
collected
faecal
samples
from
eight
MGH
GZH
to
compare
differences
using
amplicon
sequencing.
results
alpha
diversity
analysis
indicated
that
bacterial
fungal
abundance
were
significantly
higher
than
those
MGH.
Meanwhile,
beta
revealed
there
significant
structures
between
Although
dominant
phyla
same,
a
large
number
different
bacteria
fungi
both
groups.
Moreover,
observed
32
(23
9
phyla)
718
genera
(383
335
genera)
with
Notably,
study
also
some
intestinal
functions
GZH,
chemoheterotrophy,
fermentation,
cellulolysis.
To
our
knowledge,
is
first
report
on
comparative
GZH.
Our
demonstrated
richer
more
diverse
compared
Additionally,
these
important
for
understanding
horse.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 13, 2024
Due
to
the
physiological
alteration
during
pregnancy,
maternal
gut
microbiota
changes
following
metabolic
processes.
Recent
studies
have
revealed
that
is
closely
associated
with
immune
microenvironment
in
utero
pregnancy
and
plays
a
vital
role
specific
complications,
including
preeclampsia,
gestational
diabetes,
preterm
birth
recurrent
miscarriages.
Some
other
evidence
has
also
shown
aberrant
increases
risk
of
various
diseases
offspring,
such
as
allergic
neurodevelopmental
disorders,
through
alignment
between
mother
fetus
possible
intrauterine
microbiota.
Probiotics
high-fiber
diet
are
effective
inventions
prevent
mothers
fetuses
from
diseases.
In
this
review,
we
summarize
development
complications
health
condition
future
generations
perspective
immunology,
which
may
provide
new
therapeutic
strategies
for
management
offspring.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 275 - 275
Published: Jan. 13, 2025
Type
2
diabetes
mellitus
(T2DM),
a
serious
metabolic
disorder,
is
worldwide
health
problem
due
to
the
alarming
rise
in
prevalence
and
elevated
morbidity
mortality.
Chronic
hyperglycemia,
insulin
resistance,
ineffective
effect
secretion
are
hallmarks
of
T2DM,
leading
many
secondary
complications.
These
include,
particular,
cardiovascular
disorders,
diabetic
neuropathy,
nephropathy
retinopathy,
foot,
osteoporosis,
liver
damage,
susceptibility
infections
some
cancers.
Polyphenols
such
as
flavonoids,
phenolic
acids,
stilbenes,
tannins,
lignans
constitute
an
extensive
heterogeneous
group
phytochemicals
fresh
fruits,
vegetables
their
products.
Various
vitro
studies,
animal
model
studies
available
clinical
trials
revealed
that
flavonoids
(e.g.,
quercetin,
kaempferol,
rutin,
epicatechin,
genistein,
daidzein,
anthocyanins),
acids
chlorogenic,
caffeic,
ellagic,
gallic
curcumin),
stilbenes
resveratrol),
tannins
procyanidin
B2,
seaweed
phlorotannins),
pinoresinol)
have
ability
lower
enhance
sensitivity
improve
secretion,
scavenge
reactive
oxygen
species,
reduce
chronic
inflammation,
modulate
gut
microbiota,
alleviate
complications
T2DM.
The
interaction
between
polyphenols
conventional
antidiabetic
drugs
offers
promising
strategy
management
treatment
especially
advanced
disease
stages.
Synergistic
effects
with
been
documented,
but
also
antagonistic
interactions
may
impair
drug
efficacy.
Therefore,
additional
research
required
clarify
mutual
order
use
knowledge
applications.
Nevertheless,
dietary
can
be
successfully
applied
part
supportive
for
they
both
obvious
symptoms
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 30, 2025
Ischemia-reperfusion
injury
(IRI)
is
a
major
obstacle
in
liver
transplantation,
especially
with
steatotic
donor
livers.
Dysbiosis
of
the
gut
microbiota
has
been
implicated
modulating
IRI,
and
Lachnospiraceae
plays
pivotal
role
regulating
host
inflammatory
immune
responses,
but
its
specific
transplantation
IRI
remains
unclear.
This
study
explores
whether
can
mitigate
underlying
mechanisms.
We
found
Lachnospiraceae-bacterium
(Lachn.)
abundance
was
significantly
reduced
rats
cirrhosis.
Lachn.-treated
exhibited
improved
intestinal
permeability,
severity
both
normal
livers,
decreased
levels
neutrophil
macrophage
infiltration,
cytokines.
Multi-omics
analysis
revealed
elevated
pyruvate
transplanted
livers
after
Lachn.
treatment,
alongside
Alox15
Foxo3
expression.
Mechanistically,
Lachn.-derived
inhibited
expression
ferroptosis
Furthermore,
nuclear
translocation
further
suppressed
expression,
alleviating
Clinical
samples
confirmed
cirrhotic
recipients
high
transplantation.
In
conclusion,
alleviates
by
inhibiting
via
Foxo3-Alox15
axis,
providing
potential
therapeutic
strategy
to
modulate
alleviate
following
Microbiome,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Oct. 21, 2024
The
disease
resistance
phenotype
is
closely
related
to
immunomodulatory
function
and
immune
tolerance
has
far-reaching
implications
in
animal
husbandry
human
health.
Microbes
play
an
important
role
the
initiation,
prevention,
treatment
of
diseases,
but
mechanisms
host-microbiota
interactions
disease-resistant
phenotypes
are
poorly
understood.
In
this
study,
we
hope
uncover
explain
microbes
intestinal
diseases
their
action
identify
new
potential
treatments.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 794 - 794
Published: Feb. 26, 2025
This
study
was
conducted
to
investigate
the
effects
and
mechanisms
of
all-trans
lycopene
on
intestinal
health
by
establishing
lipopolysaccharide-induced
(LPS-induced)
jejunal
inflammation
model.
Dietary
supplementation
enhanced
serum
jejunum
antioxidant
capacity.
Lycopene
significantly
reduced
LPS-induced
upregulation
toll-like
receptor-4
(TLR-4)
nuclear
factor
kappa-B
(NF-κB),
suggesting
that
activation
TLR-4/NF-κB
signaling
pathway
induced
LPS
challenge,
further
protected
mice
from
inflammation.
Furthermore,
increased
zonula
occludens-1
(ZO-1)
protein
expression
abundance
Rikenella,
Lachnospiraceae_NK4A136_group
Mucispirillum
potentially
associated
with
reducing
gut
Overall,
these
results
showed
pretreatment
can
improve
ensure
in
improving
capacity,
barrier
function,
microorganisms
anti-inflammatory
LPS.
We
provided
a
new
insight
into
prevented
corresponding
alterations
metabolites
microbiota,
capacity
regulating
mice.
