Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 15125 - 15145

Published: July 24, 2023

Dietary pollution by polystyrene microplastics (MPs) can cause hepatic injuries and microbial dysbiosis. Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, exerts beneficial effects on liver modulating gut microbiota. However, role of microbiota MPs-induced protective effect EGCG have not been clarified. Here, 5 μm MPs were orally administered to mice induce injuries. Subsequently, antibiotic cocktail (ABX) fecal transplant (FMT) experiments performed investigate underlying mechanisms. Additionally, was explore its protection against Our results showed that activated systemic inflammation, promoted fibrosis, altered metabolome; meanwhile, damaged homeostasis disturbing microbiome, promoting colonic impairing intestinal barrier. Notably, reduced abundance probiotics Akkermansia, Mucispirillum, Faecalibaculum while increasing pathogenic Tuzzerella. Interestingly, elimination mitigated inflammation barrier impairment. Moreover, ABX ameliorated but fibrosis. Correspondingly, from MPs-administered induced colonic, systemic, their profibrosis observed. Finally, elevated effectively repressed inflammation. remodeling metabolome also attenuated EGCG. These findings illustrated contributed injuries, could serve as a potential prevention strategy for these adverse consequences.

Language: Английский

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Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives

Food Chemistry, Journal Year: 2022, Volume and Issue: 399, P. 133959 - 133959

Published: Aug. 18, 2022

Language: Английский

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Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154979 - 154979

Published: July 18, 2023

Language: Английский

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Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 26, 2023

Accumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, mechanisms underlying such interactions have been unclear. Here, we found glycoursodeoxycholic (GUDCA) positively microbiota by altering metabolism. GUDCA in mice resulted higher taurolithocholic (TLCA) level and Bacteroides vulgatus abundance. Together, these changes activation of adipose G-protein-coupled receptor, GPBAR1 (TGR5) upregulated expression uncoupling protein UCP-1, resulting elevation white tissue thermogenesis. The anti-T2DM effects are linked with regulation composition. This study metabolism, modifying may be value for treatment T2DM.

Language: Английский

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A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders

Cell Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 17, 2025

Abstract According to traditional Chinese medicine (TCM) constitutional theory, individuals with phlegm-dampness constitution (PDC) are at increased risk for metabolic disorders. Previous studies have indicated that PDC exhibit gene expression changes associated disorders, even normal indices. However, the biological mechanisms underlying these remain unclear. The gut microbiota has recently emerged as a promising avenue elucidating TCM principles. Here, we revealed distinct and serum metabolite profiles. A decrease in phytosphingosine was scores disorder severity. Subsequent experiments demonstrated Flavonifractor plautii can biosynthesize phytosphingosine, which also negatively correlated score. Interestingly, both F. levels decreased subjects Fecal transplantation from accelerated development of disorders mice. supplementation ameliorated by increasing gut‒hepatic axis. Mechanistic investigations confirmed directly bind hepatic peroxisome proliferator-activated receptor α (PPARα) activate its nuclear transcription activity, thereby regulating downstream related glucose‒lipid metabolism. Our research indicates product, contributes increases their susceptibility These findings suggest diagnosing may be beneficial identifying at-risk populations among apparently healthy individuals, advancing broader field prevention integration.

Language: Английский

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Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: March 18, 2022

L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms, especially in edible mushrooms. EGT found to be highly accumulated tissues that are susceptible oxidative damage, and it has attracted extensive attention due its powerful activity the tight relationships of this product with various stress-related diseases. Herein, we 1) introduce biological source vivo distribution EGT; 2) review currently available evidence concerning diabetes, ischemia-reperfusion injury-related diseases like cardiovascular liver diseases, neurodegenerative other pathogenically associated stress; 3) summarize potential action mechanisms against these diseases; 4) discuss advantages over antioxidants; 5) also propose several future research perspectives for EGT. These may help promote application attractive antioxidant.

Language: Английский

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Apigenin Alleviates Obesity-Associated Metabolic Syndrome by Regulating the Composition of the Gut Microbiome

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 3, 2022

The gut microbiota, often viewed as a "digestive organ," can influence the development of obesity and related metabolic disorders. Diet is significantly important in shaping structure modulating function microbiota. Apigenin (Api) widely exists fruits vegetables naturally occurring flavonoid has anti-obesogenic, anti-inflammatory, anti-carcinogenic properties. Its low bioavailability means it enough time to interact with intestine thus becomes potential substrate for intestine; thus, contributing health. Here, we show that Api reduces whole-body weight, low-grade inflammation, insulin resistance high-fat diet (HFD)-induced obese mice. Our results reflect supplementation substantially improve intestinal dysbiosis triggered by HFD restores barrier damage alleviating endotoxemia. Augmentation Akkermansia Incertae_Sedis along reduction Faecalibaculum Dubosiella at genus level potentially mediated protective effects on syndrome. Furthermore, impact body weight modification microbiota could be transferred from Api-administered mice HFD-feeding via horizontal fecal transplantation. Taken together, our data highlight prebiotic role its contribution restraint deterioration associated

Language: Английский

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Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 16, 2022

The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide; however, there are currently limited treatments for NAFLD. spectrum includes simple liver, steatohepatitis (NASH), fibrosis, cirrhosis, and progression to hepatocellular carcinoma (NASH-HCC). therapeutic effects NAFLD remain controversial. Although researchers have conducted studies on the pathogenesis NAFLD, its anti-NAFLD mechanisms not been fully elucidated. Previous found that flavonoids, as natural substances with extensive pharmacological activity good effects, excellent antioxidant, anti-inflammatory, metabolic improvement, anti-tumor, other properties can significantly alleviate Flavonoids could be further developed drugs In this paper, flavonoids against summarized provide a theoretical basis screening injury.

Language: Английский

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Regulation of gut microbiota by vitamin C, vitamin E and β-carotene

Food Research International, Journal Year: 2023, Volume and Issue: 169, P. 112749 - 112749

Published: March 24, 2023

Language: Английский

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Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

Food Frontiers, Journal Year: 2023, Volume and Issue: 4(4), P. 1794 - 1809

Published: Sept. 27, 2023

Abstract Flavonoids are phytochemicals that widely exist in plants, fruits, and vegetables have a variety of activities. However, due to their complex structure, it is often rarely absorbed into the blood. Intestinal bacteria regarded as third kind human organ attracted extensive attention recent years. Complex structural flavonoids can be catabolized low molecular weight phenolic acids under action intestinal then blood, showing several protective effects on body. In addition, intake also regulate composition function flora. This paper comprehensively summarizes interaction between flora, well impact health, order provide some insights how combine microorganisms select ingest dietary polyphenols for future applications medicine.

Language: Английский

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