Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(34), P. 19086 - 19097
Published: Aug. 19, 2023
Metal
oxide
nanozymes
have
emerged
as
the
most
efficient
and
promising
candidates
to
mimic
antioxidant
enzymes
for
treatment
of
oxidative
stress-mediated
pathophysiological
disorders,
but
current
effectiveness
is
unsatisfactory
due
insufficient
catalytic
performance.
Here,
we
report
first
time
an
intrinsic
strain-mediated
ultrathin
ceria
nanoantioxidant.
Surface
strain
in
with
variable
thicknesses
coordinatively
unsaturated
Ce
sites
was
investigated
by
theoretical
calculation
analysis
then
validated
preparing
∼1.2
nm
nanoplates
∼3.0%
tensile
plane/∼10.0%
out
plane.
Compared
nanocubes,
surface
could
enhance
covalency
Ce-O
bond,
leading
increasing
superoxide
dismutase
(SOD)-mimetic
activity
∼2.6-fold
(1533
U/mg,
close
proximity
that
natural
SOD)
total
∼2.5-fold.
As
a
proof
concept,
boost
antioxidation
improved
ischemic
stroke
vivo,
significantly
better
than
edaravone,
commonly
used
clinical
drug.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
Analytical Chemistry,
Journal Year:
2021,
Volume and Issue:
93(19), P. 7275 - 7282
Published: May 6, 2021
Organophosphorus
pesticides
(OPs)
can
inhibit
the
activity
of
acetylcholinesterase
(AChE)
to
induce
neurological
diseases.
It
is
significant
exploit
a
rapid
and
sensitive
strategy
monitor
OPs.
Here,
metal–organic
framework
(MOF)
acted
as
carrier
encapsulate
AuNCs,
which
limit
molecular
motion
trigger
aggregation-induced
emission
(AIE)
effect,
exhibit
strong
fluorescence
with
lifetime
quantum
yield
6.83
μs
4.63%,
respectively.
Then,
marriage
colorimetric
signals
was
realized
on
basis
dual
function
enzymolysis
product
from
AChE
choline
oxidase
(CHO)
AuNCs@ZIF-8.
First,
it
decompose
ZIF-8
weaken
restraint
thus
receded.
Second,
be
used
substrate
for
peroxidase
mimics
released
AuNCs
oxidize
3,3′,5,5′-tetramethylbenzidine
(TMB)
visible
blue
appeared.
Thus,
inhibition
by
OPs,
fluorescence–colorimetric
dual-signal
biosensor
established.
In
addition,
paper
strips
were
exploited
realize
visual
semiquantitative
detection,
smartphone
APP
developed
make
visualization
results
more
precise
real-time
supervision
pesticide
contamination.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(10)
Published: Feb. 25, 2023
Nanomaterials
with
more
than
one
enzyme-like
activity
are
termed
multienzymic
nanozymes,
and
they
have
received
increasing
attention
in
recent
years
hold
huge
potential
to
be
applied
diverse
fields,
especially
for
biosensing
therapeutics.
Compared
single
nanozymes
offer
various
unique
advantages,
including
synergistic
effects,
cascaded
reactions,
environmentally
responsive
selectivity.
Nevertheless,
along
these
merits,
the
catalytic
mechanism
rational
design
of
complicated
elusive
as
compared
single-enzymic
nanozymes.
In
this
review,
classification
scheme
based
on
numbers/types
activities,
internal
external
factors
regulating
multienzymatic
chemical,
biomimetic,
computer-aided
strategies,
progress
applications
attributed
advantages
multicatalytic
activities
systematically
discussed.
Finally,
current
challenges
future
perspectives
regarding
development
application
suggested.
This
review
aims
deepen
understanding
inspire
research
a
greater
extent.
Science Advances,
Journal Year:
2021,
Volume and Issue:
7(39)
Published: Sept. 22, 2021
Ferroptosis,
an
emerging
type
of
cell
death
found
in
the
past
decades,
features
specifically
lipid
peroxidation
during
process
commonly
by
iron
accumulation.
Unfortunately,
however,
direct
delivery
species
may
trigger
undesired
detrimental
effects
such
as
anaphylactic
reactions
normal
tissues.
Up
to
date,
reports
on
cellular
ferroptosis
using
nonferrous
metal
elements
can
be
rarely
found.
In
this
work,
we
propose
a
ferroptosis-like
strategy
based
hybrid
CoMoO4-phosphomolybdic
acid
nanosheet
(CPMNS)–enabled
peroxide
(LOOH)
accumulation
via
accelerated
Mo(V)-Mo(VI)
transition,
elevated
GSH
depletion
for
GPX4
enzyme
deactivation,
and
ROS
burst,
efficient
chemotherapy.
Both
vitro
vivo
outcomes
demonstrate
notable
anticancer
efficacy,
suggesting
high
feasibility
CPMNS-enabled
therapeutic
concept.
It
is
highly
expected
that
design
nanocatalytic
medicine
would
beneficial
future
advances
field
cancer-therapeutic
regimens.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(24), P. 9121 - 9153
Published: Jan. 1, 2020
The
present
review
focuses
on
the
use
of
Metal–Organic
Frameworks,
(MOFs)
highlighting
most
recent
developments
in
biological
field
and
as
bio-sensors.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(3), P. 1227 - 1234
Published: Oct. 6, 2020
Glutathione
peroxidase
(GPx)
plays
an
important
role
in
maintaining
the
reactive
oxygen
metabolic
balance,
yet
limited
GPx-mimicking
nanozymes
are
currently
available
for
vivo
therapy.
Herein,
a
ligand
engineering
strategy
is
developed
to
modulate
activity
of
metal-organic
framework
(MOF)
nanozyme.
With
different
substituted
ligands,
activities
MIL-47(V)-X
(MIL
stands
Materials
Institute
Lavoisier;
X=F,
Br,
NH2
,
CH3
OH,
and
H)
MOFs
rationally
regulated.
best
one
as
example,
both
vitro
experiments
reveal
excellent
antioxidation
ability
MIL-47(V)-NH2
which
alleviates
inflammatory
response
effectively
ear
injury
colitis,
more
active
than
MIL-47(V).
This
study
proves
that
high-performance
can
be
designed
by
strategy,
structure-activity
relationships
direct
enriches
nanozyme
research
expands
range
biomimetic
MOFs.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(14), P. 6065 - 6086
Published: Jan. 1, 2022
This
review
critically
evaluates
the
recent
advancements
in
understanding
of
endocytosis
nano-sized
metal–organic
frameworks
and
importance
biological
context
aiding
MOF
rational
design
synthesis
for
drug
delivery
applications.
