Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(39)
Published: June 7, 2023
Drug
delivery
systems
(DDSs)
are
designed
to
deliver
therapeutic
agents
specific
target
sites
while
minimizing
systemic
toxicity.
Recent
developments
in
drug-loaded
DDSs
have
demonstrated
promising
characteristics
and
paved
new
pathways
for
cancer
treatment.
Light,
a
prevalent
external
stimulus,
is
widely
utilized
trigger
drug
release.
However,
conventional
light
sources
primarily
concentrate
on
the
ultraviolet
(UV)
visible
regions,
which
suffer
from
limited
biological
tissue
penetration.
This
limitation
hinders
applications
deep-tissue
tumor
Given
their
deep
penetration
well-established
application
technology,
X-rays
recently
received
attention
pursuit
of
controlled
With
precise
spatiotemporal
dosage
controllability,
stand
as
an
ideal
stimulus
achieving
release
therapy.
article
explores
recent
advancements
using
stimulus-triggered
delves
into
action
mechanisms.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(21)
Published: July 21, 2023
Abstract
Chemotherapy
is
widely
recognized
as
an
effective
approach
for
treating
cancer
due
to
its
ability
eliminate
cells
using
chemotherapeutic
drugs.
However,
traditional
chemotherapy
suffers
from
various
drawbacks,
including
limited
solubility
and
stability
of
drugs,
severe
side
effects,
low
bioavailability,
drug
resistance,
challenges
in
tracking
treatment
efficacy.
These
limitations
greatly
hinder
widespread
clinical
application.
In
contrast,
supramolecular
chemotherapy,
which
relies
on
host–guest
interactions,
presents
a
promising
alternative
by
offering
highly
efficient
minimally
toxic
anticancer
delivery.
this
review,
overview
recent
advancements
based
interactions
provided.
The
significant
role
it
plays
guiding
therapy
emphasized.
Drawing
wealth
cutting‐edge
research,
herein,
timely
valuable
resource
individuals
interested
the
field
or
therapy,
presented.
Furthermore,
review
contributes
progression
toward
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 24, 2023
Abstract
The
stimuli-responsive
nanofibers
prepared
by
electrospinning
have
become
an
ideal
material
due
to
their
large
specific
surface
area
and
porosity,
which
can
respond
extremely
quickly
external
environmental
incitement.
As
intelligent
drug
delivery
platform,
efficiently
load
drugs
then
be
stimulated
conditions
(light,
temperature,
magnetic
field,
ultrasound,
pH
or
ROS,
etc.)
achieve
slow,
on-demand
targeted
release,
showing
great
potential
in
areas
such
as
delivery,
tumor
therapy,
wound
dressing,
tissue
engineering.
Therefore,
this
paper
reviews
the
recent
trends
of
electrospun
platforms
field
biomedicine.
Photodiagnosis and Photodynamic Therapy,
Journal Year:
2024,
Volume and Issue:
45, P. 103959 - 103959
Published: Jan. 21, 2024
Breast
cancer
(BC)
remains
an
enigmatic
fatal
modality
ubiquitously
prevalent
in
different
parts
of
the
world.
Contemporary
medicines
face
severe
challenges
remediating
and
healing
breast
cancer.
Due
to
its
spatial
specificity
nominal
invasive
therapeutic
regime,
photothermal
therapy
(PTT)
has
attracted
much
scientific
attention
down
lane.
PTT
utilizes
a
near-infrared
(NIR)
light
source
irradiate
tumor
target
intravenously
or
non-invasively,
which
is
converted
into
heat
energy
over
optical
fibre.
Dynamic
progress
nanomaterial
synthesis
was
achieved
with
specialized
visual,
physicochemical,
biological,
pharmacological
features
make
up
for
inadequacies
expand
horizon
PTT.
Numerous
nanomaterials
have
substantial
NIR
absorption
can
function
as
efficient
transducers.
It
achievable
limit
wavelength
range
absorbance
peak
specific
by
manipulating
their
synthesis,
enhancing
precision
quality
Along
same
lines,
various
are
conjugated
wide
surface-modifying
chemicals,
including
polymers
antibodies,
may
modify
persistence
diminish
toxicity
concerns.
In
this
article,
we
tend
put
forth
insights
fundamental
conceptualizations
on
pre-existing
advances
upon
conjugation
biocompatible
working
synergy
combat
cancer,
encompassing
several
strategies
like
immunotherapy,
chemotherapy,
photodynamic
therapy,
radiotherapy
coupled
Additionally,
role
mechanisms
nanoparticles,
well
possible
alternatives
PTT,
summarized
distinctive
integral
aspect
article.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(7), P. 6601 - 6614
Published: March 31, 2023
Prodrug
nanoassemblies
combine
the
advantages
of
prodrug
and
nanomedicines,
offering
great
potential
in
targeting
lesion
sites
specific
on-demand
drug
release,
maximizing
therapeutic
performance
while
minimizing
their
side
effects.
However,
there
is
still
lacking
a
facile
pathway
to
prepare
lipid
(LPNAs).
Herein,
we
report
LPNAs
via
dynamic
covalent
boronate
between
catechol
boronic
acid.
The
resulting
possess
properties
like
loading
manner,
charge
reversal
an
acidic
microenvironment,
release
at
and/or
oxidative
microenvironment.
Our
methodology
enables
encapsulation
delivery
three
model
drugs:
ciprofloxacin,
bortezomib,
miconazole.
Moreover,
are
often
more
efficient
eradicating
pathogens
or
cancer
cells
than
free
counterparts,
both
vitro
vivo.
Together,
our
with
intriguing
may
boost
development
facilitate
clinical
applications.
