Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment DOI Creative Commons
Tian Liu, Lingxiao Li, Shuo Wang

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 24, 2022

Abstract Sulfur bonds, especially trisulfide bond, have been found to ameliorate the self-assembly stability of homodimeric prodrug nanoassemblies and could trigger sensitive reduction-responsive release active drugs. However, antitumor efficacy with single reduction-responsivity may be restricted due heterogeneous tumor redox microenvironment. Herein, we replace middle sulfur atom bond an oxidizing tellurium or selenium construct dual-responsive sulfur-tellurium-sulfur sulfur-selenium-sulfur hybrid chalcogen bonds. The exhibit ultrahigh dual-responsivity both oxidation reduction conditions, which effectively address Moreover, promotes prodrugs by providing strong intermolecular forces sufficient steric hindrance. above advantages bridged result in improved docetaxel satisfactory safety. exploration bonds drug delivery deepened insight into development prodrug-based chemotherapy heterogeneity, thus enriching design theory nanomedicines.

Language: Английский

Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems DOI Creative Commons

Fengxiang Gao,

Zhengrong Xiong

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: April 23, 2021

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms; however, as the concentration ROS increases area a lesion, this may undermine cellular homeostasis, leading to series diseases. Using cell-product triggers for targeted regulation polymer structures and activity represents promising approach treatment. ROS-responsive carriers allow delivery drugs, reduce toxicity side effects on normal cells, control release which are all advantages compared with traditional small-molecule chemotherapy agents. These formulations have attracted great interest due their potential applications biomedicine. In review, recent progresses responsive summarized, focus chemical mechanism polymers design molecular drug controlled release. Meanwhile, we discuss challenges future prospects its applications.

Language: Английский

Citations

61
Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy DOI
Kewei Wang,

Maolin Jiang,

Jielian Zhou

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(1), P. 721 - 735

Published: Jan. 3, 2022

Hypoxia, a common feature of most solid tumors, causes severe tumor resistance to chemotherapy and immunotherapy. Herein, tumor-acidity bioorthogonal chemistry-mediated on-site size transformation clustered nanosystem is designed overcome hypoxic enhance chemoimmunotherapy. The utilized the responsive group poly(2-azepane ethyl methacrylate) with rapid response rate highly efficient click chemistry form large-sized aggregates in tissue accumulation retention. Subsequently, another maleic acid amide slow was cleaved allowing slowly dissociate into ultrasmall nanoparticles better penetration ability for delivery doxorubicin (DOX) nitric oxide (NO) tissue. NO can reverse hypoxia-induced DOX boost antitumor immune through reprogrammed microenvironment. This not only helps counteract chemoresistance responses but also provides general drug strategy enhanced penetration.

Language: Английский

Citations

57
Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy DOI Creative Commons

Xiujuan Xiang,

Xuan Feng,

Shaojin Lu

et al.

Exploration, Journal Year: 2022, Volume and Issue: 2(4)

Published: June 4, 2022

Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. However, the nanoparticle formulas usually contain multiple components, especially polymeric materials, which result various issues. Herein, we report an indocyanine green (ICG)-driven assembly of paclitaxel prodrugs integrating near-infrared fluorescence imaging tumor-specific chemotherapy. By feat hydrophilic merit ICG, dimer could form more uniformly monodispersed nanoparticles. This two-in-one strategy reinforces complementary advantages, resulting superior behavior, robust colloidal stability, enhanced accumulation as well desirable vivo feedback The experiments validated activation at sites evidenced by intensity, potent growth suppression, reduced systemic toxicity compared commercial Taxol. universality ICG potentiated toward photosensitizers dyes was confirmed. presentation provides deep insight into feasibility constructing clinical-close alternatives for improving antitumor efficacy.

Language: Английский

Citations

55
Tumor Microenvironment-Responsive Yolk–Shell NaCl@Virus-Inspired Tetrasulfide-Organosilica for Ion-Interference Therapy via Osmolarity Surge and Oxidative Stress Amplification DOI
Yang Li, Jinyan Lin, Peiyuan Wang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7380 - 7397

Published: April 18, 2022

Ion-interference therapy, which utilizes ions to disturb intracellular biological processes, provides inspiration for tumor therapy. Artificially reversing osmotic pressure by transporting large amounts of physiological cells is a straightforward yet low-toxic strategy ion-interference However, it hard achieve due the serious limitations single-ion delivery. Herein, we skillfully deliver NaCl nanocrystals sites and sequentially realize explosive release Na+/Cl– inside utilizing virus-mimicking glutathione (GSH)-responsive hollow mesoporous tetrasulfide-bridged organosilica (ssss-VHMS). Once ssss-VHMS-wrapped (NaCl@ssss-VHMS) accumulate in tumors, they would rapidly invade via spike surface-assisted endocytosis, thus bypassing Na+/K+-ATPase transmembrane ion transporters. Afterward, overproduced GSH trigger rapid degradation ssss-VHMS thiol–tetrasulfide exchange, could not only remarkably deplete but also explosively Na+/Cl–, leading osmolarity surge accompanied reactive oxygen species (ROS) generation. The cell swelling, ROS storm, exhaustion NaCl@ssss-VHMS effectively eradicated caspase-1-dependent pyroptosis, caspase-3-dependent apoptosis, GPX4-dependent ferroptosis, respectively, synergistically inhibiting growth. We believe that be potential cancer therapeutic agent, this discovery provide perspective exploring synergistic

Language: Английский

Citations

54
Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment DOI Creative Commons
Tian Liu, Lingxiao Li, Shuo Wang

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 24, 2022

Abstract Sulfur bonds, especially trisulfide bond, have been found to ameliorate the self-assembly stability of homodimeric prodrug nanoassemblies and could trigger sensitive reduction-responsive release active drugs. However, antitumor efficacy with single reduction-responsivity may be restricted due heterogeneous tumor redox microenvironment. Herein, we replace middle sulfur atom bond an oxidizing tellurium or selenium construct dual-responsive sulfur-tellurium-sulfur sulfur-selenium-sulfur hybrid chalcogen bonds. The exhibit ultrahigh dual-responsivity both oxidation reduction conditions, which effectively address Moreover, promotes prodrugs by providing strong intermolecular forces sufficient steric hindrance. above advantages bridged result in improved docetaxel satisfactory safety. exploration bonds drug delivery deepened insight into development prodrug-based chemotherapy heterogeneity, thus enriching design theory nanomedicines.

Language: Английский

Citations

51