Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 6, 2024
Abstract
Background
Elevated
interstitial
fluid
pressure
within
tumors,
resulting
from
impaired
lymphatic
drainage,
constitutes
a
critical
barrier
to
effective
drug
penetration
and
therapeutic
outcomes.
Results
In
this
study,
based
on
the
photosynthetic
characteristics
of
algae,
an
active
carrier
(CP@ICG)
derived
Chlorella
pyrenoidos
(CP)
was
designed
constructed.
Leveraging
hypoxia
tropism
phototropism
exhibited
by
CP,
we
achieved
targeted
transport
tumor
sites.
Additionally,
dual
near-infrared
(NIR)
irradiation
at
site
facilitated
photosynthesis
in
enabling
breakdown
excessive
intratumoral
generating
oxygen
water
decomposition.
This
process
effectively
reduced
pressure,
thereby
promoting
enhanced
perfusion
blood
into
tumor,
significantly
improving
deep-seated
chemotherapeutic
agents,
alleviating
hypoxia.
Conclusions
CP@ICG
demonstrated
combined
effect
photothermal/photodynamic/starvation
therapy,
exhibiting
excellent
vitro/in
vivo
anti-tumor
efficacy
favorable
biocompatibility.
work
provides
scientific
foundation
for
application
microbial-enhanced
delivery
therapy.
Graphical
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 9994 - 10041
Published: June 22, 2022
Worldwide
nanotechnology
development
and
application
have
fueled
many
scientific
advances,
but
technophilic
expectations
technophobic
demands
must
be
counterbalanced
in
parallel.
Some
of
the
burning
issues
today
are
following:
(1)
Where
is
nano
today?
(2)
How
good
communication
investment
networks
between
academia/research
governments?
(3)
Is
there
any
spotlight
for
nanotechnology?
Nanomedicine
a
particular
arm
within
healthcare
landscape,
focused
on
diagnosis,
treatment,
monitoring
emerging
(such
as
coronavirus
disease
2019,
COVID-19)
contemporary
(including
diabetes,
cardiovascular
diseases,
neurodegenerative
disorders,
cancer)
diseases.
However,
it
may
only
represent
bright
side
coin.
In
fact,
recent
past,
concept
nanotoxicology
has
emerged
to
address
dark
shadows
nanomedicine.
The
nanomedicine
field
requires
more
nanotoxicological
studies
identify
undesirable
effects
guarantee
safety.
Here,
we
provide
an
overall
perspective
central
pieces
giant
puzzle
nanotechnology.
First,
impact
education
research
highlighted,
followed
by
market
trends
output
tendencies.
next
section,
dilemma
addressed
through
interplay
silico,
vitro,
vivo
models
with
support
omics
microfluidic
approaches.
Lastly,
reflection
regulatory
clinical
trials
provided.
Finally,
some
conclusions
future
perspectives
proposed
clearer
safer
translation
nanomedicines
from
bench
bedside.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(10), P. 8935 - 8965
Published: May 1, 2023
Nitric
oxide
(NO),
a
gaseous
transmitter
extensively
present
in
the
human
body,
regulates
vascular
relaxation,
immune
response,
inflammation,
neurotransmission,
and
other
crucial
functions.
Nitrite
donors
have
been
used
clinically
to
treat
angina,
heart
failure,
pulmonary
hypertension,
erectile
dysfunction.
Based
on
NO's
vast
biological
functions,
it
further
can
tumors,
bacteria/biofilms
infections,
wound
healing,
eye
diseases,
osteoporosis.
However,
delivering
NO
is
challenging
due
uncontrolled
blood
circulation
release
half-life
of
under
five
seconds.
With
advanced
biotechnology
development
nanomedicine,
packaged
with
multifunctional
nanocarriers
by
physically
embedding
or
chemically
conjugating
reported
show
improved
therapeutic
efficacy
reduced
side
effects.
Herein,
we
review
discuss
recent
applications
nanomedicines,
their
mechanisms,
challenges
nanomedicines
for
future
scientific
studies
clinical
applications.
As
enables
inhibition
replication
DNA
RNA
infectious
microbes,
including
COVID-19
coronaviruses
malaria
parasites,
highlight
potential
antipandemic
efforts.
This
aims
provide
deep
insights
practical
hints
into
design
strategies
nanomedicines.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Dec. 2, 2022
Bioorthogonal
chemistry
reactions
occur
in
physiological
conditions
without
interfering
with
normal
processes.
Through
metabolic
engineering,
bioorthogonal
groups
can
be
tagged
onto
cell
membranes,
which
selectively
attach
to
cargos
paired
via
reactions.
Due
its
simplicity,
high
efficiency,
and
specificity,
has
demonstrated
great
application
potential
drug
delivery.
On
the
one
hand,
improve
therapeutic
agent
delivery
target
sites,
overcoming
off-target
distribution.
other
nanoparticles
biomolecules
linked
membranes
by
reactions,
providing
approaches
developing
multi-functional
systems
(DDSs).
In
this
review,
we
first
describe
principle
of
labeling
cells
or
pathogenic
microorganisms
groups.
We
then
highlight
recent
breakthroughs
active
targeting
DDSs
tumors,
immune
systems,
bacteria
chemistry,
as
well
applications
functional
bio-inspired
(biomimetic
DDSs,
cell-based
bacteria-based
phage-based
DDSs)
hydrogels.
Finally,
discuss
difficulties
prospective
direction
expect
review
will
help
us
understand
latest
advances
development
using
inspire
innovative
smart
for
disease
treatment.
Small Methods,
Journal Year:
2023,
Volume and Issue:
7(5)
Published: Jan. 5, 2023
Immunogenic
cell
death
(ICD,
also
known
as
immunogenic
apoptosis)
of
malignant
cells
is
confirmed
to
activate
the
host
immune
system
prevent,
control,
and
eliminate
tumors.
Recently,
a
range
chemotherapeutic
drugs
have
been
repurposed
ICD
inducers
applied
for
tumor
immunotherapy.
However,
several
hurdles
widespread
application
remain,
namely
poor
water
solubility,
short
blood
circulation,
non-specific
tissue
distribution,
severe
toxicity.
Recent
advances
in
nanotechnology
pharmaceutical
formulation
foster
development
nano
drug
delivery
systems
tackle
aforementioned
expedite
safe,
effective,
specific
delivery.
This
review
will
describe
barriers
chemical
highlight
recent
nanoformulations
these
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(17)
Published: Jan. 2, 2024
Abstract
Gas
therapy,
represented
by
nitric
oxide
(NO),
has
shown
a
powerful
anti‐tumor
effect.
However,
current
NO
therapy
relies
on
precursors,
which
are
often
released
prematurely
during
in
vivo
delivery,
resulting
poor
targeting
and
obvious
toxic
side
effects.
Herein,
core/shell‐structured
nanocatalyst
is
designed
prepared
to
catalyze
the
generation
of
tumor
without
introduction
donor.
In
this
system,
C‐Z@CM
coating
octahedron
Cu‐MOF
with
nano‐ZnO,
camouflaging
homologous
cell
membrane.
After
nanomedicine
taken
up
cells,
ZnO
reacts
situ
endogenous
S‐nitrosoglutathione
(GSNO),
highly
expressed
tumors,
continuously
stably
generate
NO.
addition,
dispersed
copper
ions
acts
as
catalytic
active
centers
Fenton‐like
reaction,
catalyzes
H
2
O
large
number
hydroxyl
radicals
(
•
OH).
Importantly,
cascade
reactive
oxygen
species
(ROS)
leads
massive
production
more
lethal
nitrogen
(RNS),
further
enhancing
therapeutic
Catalytic
high
concentrations
tumor,
combined
ROS
RNS,
accompanied
glutathione
(GSH)
depletion,
achieving
effective
suppression.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 6, 2025
Breast
cancer
(BC)
is
a
significant
cause
of
cancer-related
deaths
among
women
worldwide.
Hypoxia,
common
feature
solid
tumor,
associated
with
drug
resistance
and
poor
prognosis
in
BC.
In
this
study,
we
present
strategy
to
overcome
hypoxia-induced
chemotherapy
tolerance
Specifically,
synthesized
hollow
gold
(Au)-platinum
(Pt)
bimetallic
nanoshell
for
the
first
time,
which
acted
as
delivery
system
(DDS)
doxorubicin
(DOX).
The
photothermal
effect,
induced
by
surface
plasmon
resonance
(SPR)
from
Au-Pt
shell
under
near
infrared-II
(NIR-II)
laser
irradiation,
not
only
directly
causes
tumor
cell
death
through
therapy
(PTT),
but
also
significantly
enhances
catalase-like
activity
between
Pt
nanoparticles
endogenous
H2O2.
This,
subsequently,
results
heightened
yield
O2,
further
facilitates
release
DOX.
This
process
alleviates
hypoxia
down-regulating
hypoxia-inducible
factor-1α
(HIF-1α),
multidrug
gene
1
(MDR1),
P-glycoprotein
(P-gp),
can
reverse
achieve
more
effective
DOX
effects.
Significantly,
increased
availability
oxygen
re-polarizes
immunosuppressive
M2
macrophages
into
antitumor
M1
macrophages.
study
presents
novel
tackle
proliferation
enhance
response
chemotherapy,
offering
hope
reversing
cancerous
lesions.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(38)
Published: May 18, 2022
Abstract
Globally,
liver
cancer,
which
is
one
of
the
major
cancers
worldwide,
has
attracted
growing
attention
technological
researchers
for
its
high
mortality
and
limited
treatment
options.
Hydrogels
are
soft
3D
network
materials
containing
a
large
number
hydrophilic
monomers.
By
adding
moieties
such
as
nitrobenzyl
groups
to
structure
cross‐linked
nanocomposite
hydrogel,
click
reaction
improves
drug‐release
efficiency
in
vivo,
survival
rate
prolongs
time
cancer
patients.
The
application
hydrogel
drug
delivery
system
can
not
only
enrich
concentration
at
tumor
site
long
but
also
effectively
prevents
distant
metastasis
residual
cells.
At
present,
researches
have
been
working
toward
construction
responsive
systems,
there
few
comprehensive
articles
systematically
summarize
these
discoveries.
Here,
this
systematic
review
summarizes
synthesis
methods
related
applications
hydrogels
with
actions
external
or
internal
physiological
stimuli.
With
different
physical
chemical
stimuli,
structural
unit
rearrangement
controlled
release
drugs
be
used
states.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(9), P. 13919 - 13932
Published: Sept. 9, 2022
The
triple-negative
breast
cancer
(TNBC)
microenvironment
makes
a
feature
of
aberrant
vasculature,
high
interstitial
pressure,
and
compact
extracellular
matrix,
which
combine
to
reduce
the
delivery
penetration
therapeutic
agents,
bringing
about
incomplete
elimination
cells.
Herein,
employing
tumor
strategy
size-shrinkage
combined
with
ligand
modification,
we
constructed
photothermal
nanocluster
for
cascaded
deep
in
parenchyma
efficient
eradication
TNBC
In
our
approach,
agent
indocyanine
green
(ICG)
is
laded
human
serum
albumin
(HSA),
cross-linked
by
thermally
labile
azo
linker
(VA057)
then
further
modified
homing/penetrating
tLyP-1
peptide
(HP),
resulting
TNBC-targeting
photothermal-responsive
size-switchable
(ICG@HSA-Azo-HP).
Aided
enhanced
permeability
retention
effect
guidance
HP,
ca.
149
nm
nanoclusters
selectively
accumulate
site
then,
upon
mild
irradiation
808
laser,
disintegrate
into
11
fractions
that
possess
intratumoral
diffusion
ability.
Meanwhile,
HP
initiates
CendR
pathway
among
nutrient-deficient
cells
facilitates
transcellular
its
disintegrated
subsequent
therapy.
By
this
peptide-initiated
transcytosis
strategy,
ICG@HSA-Azo-HP
possesses
excellent
capabilities
shows
extensive
depth
three-dimensional
multicellular
spheroids
after
irradiation.
Moreover,
superior
conversion
effect,
tumor-penetrating
can
implement
effective
therapy
throughout
tissue
under
second
robust
Both
vivo
orthotopic
ectopic
confirmed
inhibition
dual-stage
synergistic
on-demanded
accompanied
clinically
feasible
NIR
provides
promising
approach
deep-penetrating
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: April 2, 2022
Local
hypoxia
is
a
common
feature
of
many
solid
tumors
and
may
lead
to
unsatisfactory
chemotherapy
outcomes.
Anaerobic
bacteria
that
have
an
affinity
hypoxic
areas
can
be
used
achieve
targeted
drug
delivery
in
tumor
tissues.
In
this
study,
we
developed
biocompatible
bacteria/nanoparticles
biohybrid
(Bif@DOX-NPs)
platform
employs
the
anaerobic
Bifidobacterium
infantis
(Bif)
deliver
adriamycin-loaded
bovine
serum
albumin
nanoparticles
(DOX-NPs)
into
breast
tumors.
The
Bif@DOX-NPs
retained
targeting
ability
B.
regions,
as
well
cytotoxicity
DOX.
biohybrids
were
able
actively
colonize
significantly
increased
accumulation
at
site.
DOX
concentration
masses
colonized
by
was
4
times
higher
than
free
DOX-treated
tumors,
which
prolonged
median
survival
tumor-bearing
mice
69
days
reduced
toxic
side-effects
Thus,
bacteria-based
are
highly
promising
tool
for
treatment
with
inaccessible
regions.
Drug Delivery,
Journal Year:
2022,
Volume and Issue:
29(1), P. 1684 - 1697
Published: May 26, 2022
Chemotherapy
for
tumors
occasionally
results
in
drug
resistance,
which
is
the
major
reason
treatment
failure.
Higher
doses
could
improve
therapeutic
effect,
but
higher
toxicity
limits
further
treatment.
For
overcoming
functional
nano-drug
delivery
system
(NDDS)
has
been
explored
to
sensitize
anticancer
drugs
and
decrease
its
side
effects,
are
applied
combating
multidrug
resistance
(MDR)
via
a
variety
of
mechanisms
including
bypassing
efflux,
controlling
release,
disturbing
metabolism.
This
review
starts
with
brief
report
on
MDR
causes.
Furthermore,
we
searched
papers
from
NDDS
introduced
recent
advances
sensitizing
chemotherapeutic
against
tumors.
Finally,
concluded
that
was
based
several
mechanisms,
looked
forward
future
this
field.