Journal of Biological Rhythms,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Circadian
disruption
is
pervasive
in
modern
society
and
associated
with
increased
risk
of
disease.
Chronic
jet
lag
paradigms
are
popular
experimental
tools
aiming
to
emulate
human
circadian
experienced
during
rotating
night
shift
work.
induces
metabolic
phenotypes
tied
liver
systemic
functions,
yet
lack
a
clear
definition
for
how
rhythmic
physiology
impaired
under
these
conditions
hinders
the
ability
identify
underlying
molecular
mechanisms.
Here,
we
compared
2
common
chronic
found
that
neither
induced
arrythmicity
each
had
distinct
effects
on
rhythmicity.
Instead,
more
frequent
8-h
forward
shifts
light
schedule
severe
misalignment
non-fasted
hyperglycemia.
Every
other
day
eventually
uncoupled
behavioral
hepatic
rhythms
from
cycle,
reminiscent
free-running
conditions.
These
results
point
misalignment,
not
arrhythmicity,
as
initial
disturbance
dysfunction
environmental
highlight
considerations
interpretation
design
studies.
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(3), P. 1693 - 1787
Published: Jan. 5, 2023
Human
skeletal
muscle
demonstrates
remarkable
plasticity,
adapting
to
numerous
external
stimuli
including
the
habitual
level
of
contractile
loading.
Accordingly,
function
and
exercise
capacity
encompass
a
broad
spectrum,
from
inactive
individuals
with
low
levels
endurance
strength
elite
athletes
who
produce
prodigious
performances
underpinned
by
pleiotropic
training-induced
muscular
adaptations.
Our
current
understanding
signal
integration,
interpretation,
output
coordination
cellular
molecular
mechanisms
that
govern
plasticity
across
this
continuum
is
incomplete.
As
such,
training
methods
their
application
largely
rely
on
“trial-and-error”
approach,
experience
practices
successful
coaches
often
providing
bases
for
“post
hoc”
scientific
enquiry
research.
This
review
provides
synopsis
morphological
functional
changes
along
underlying
adaptation
endurance-
resistance-based
training.
These
traits
are
placed
in
context
innate
genetic
interindividual
differences
performance,
special
consideration
given
aging
athletes.
Collectively,
we
provide
comprehensive
overview
response
different
modes
how
such
adaptations
translate
“molecules
medals.”
Science,
Journal Year:
2024,
Volume and Issue:
384(6695), P. 563 - 572
Published: May 2, 2024
A
molecular
clock
network
is
crucial
for
daily
physiology
and
maintaining
organismal
health.
We
examined
the
interactions
importance
of
intratissue
networks
in
muscle
tissue
maintenance.
In
arrhythmic
mice
showing
premature
aging,
we
created
a
basic
module
involving
central
peripheral
(muscle)
clock.
Reconstituting
brain-muscle
sufficient
to
preserve
fundamental
homeostatic
functions
prevent
aging.
However,
achieving
whole
requires
contributions
from
other
clocks.
Mechanistically,
acts
as
gatekeeper,
selectively
suppressing
detrimental
signals
while
integrating
important
functions.
Our
research
reveals
interplay
between
clocks
function
underscores
impact
eating
patterns
on
these
interactions.
Cell Reports,
Journal Year:
2023,
Volume and Issue:
42(6), P. 112588 - 112588
Published: June 1, 2023
Physiology
is
regulated
by
interconnected
cell
and
tissue
circadian
clocks.
Disruption
of
the
rhythms
generated
concerted
activity
these
clocks
associated
with
metabolic
disease.
Here
we
tested
interactions
between
in
two
critical
components
organismal
metabolism,
liver
skeletal
muscle,
rescuing
clock
function
either
each
organ
separately
or
both
organs
simultaneously
otherwise
clock-less
mice.
Experiments
showed
that
individual
are
partially
sufficient
for
glucose
yet
connections
coupled
to
daily
feeding
support
systemic
tolerance.
This
synergy
relies
part
on
local
transcriptional
control
machinery,
feeding-responsive
signals
such
as
insulin,
cycles
connect
muscle
liver.
We
posit
spatiotemporal
mechanisms
play
an
essential
role
maintenance
homeostasis
disrupting
this
diurnal
coordination
can
contribute
Cell & Bioscience,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Jan. 2, 2023
Abstract
Bmal1
(Brain
and
muscle
arnt-like,
or
Arntl)
is
a
bHLH/PAS
domain
transcription
factor
central
to
the
transcription/translation
feedback
loop
of
biologic
clock.
Although
well-established
as
major
regulator
circadian
rhythm,
growing
number
studies
in
recent
years
have
shown
that
dysfunction
underlies
variety
psychiatric,
neurodegenerative-like,
endocrine
metabolism-related
disorders,
well
potential
oncogenic
roles.
In
this
review,
we
systematically
summarized
expression
different
brain
regions,
its
neurological
functions
related
not
rhythm
biological
clock,
pathological
phenotypes
arising
from
knockout.
This
review
also
discusses
oscillation
rhythmicity,
especially
suprachiasmatic
nucleus,
provides
perspective
on
future
progress
research.
Acta Physiologica,
Journal Year:
2025,
Volume and Issue:
241(2)
Published: Jan. 13, 2025
Exposure
to
light
at
night
and
meal
time
misaligned
with
the
light/dark
(LD)
cycle-typical
features
of
daily
life
in
modern
24/7
society-are
associated
negative
effects
on
health.
To
understand
mechanism,
we
developed
a
novel
protocol
complex
chronodisruption
(CD)
which
exposed
female
rats
four
weekly
cycles
consisting
5-day
intervals
constant
2-day
food
access
restricted
phase
12:12
LD
cycle.
We
examined
CD
behavior,
estrous
cycle,
sleep
patterns,
glucose
homeostasis
profiles
clock-
metabolism-related
gene
expression
(using
RT
qPCR)
liver
metabolome
lipidome
untargeted
metabolomic
lipidomic
profiling).
attenuated
rhythmic
output
central
clock
suprachiasmatic
nucleus
via
Prok2
signaling,
thereby
disrupting
locomotor
activity,
mutual
relationship
between
peripheral
clocks.
In
periphery,
abolished
Per1,2
rhythms
tissues
(liver,
pancreas,
colon)
worsened
homeostasis.
liver,
it
impaired
NAD+,
lipid,
cholesterol
metabolism
genes
most
high-amplitude
lipids
polar
metabolites.
Interestingly,
circadian
rhythm
Cpt1a
increased
levels
long-chain
acylcarnitines
(ACar
18:2,
ACar
16:0),
indicating
enhanced
fatty
acid
oxidation
mitochondria.
Our
data
show
widespread
point
ACars
as
biomarkers
for
due
feeding
patterns.
