Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism DOI Creative Commons
Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis

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Cell, Journal Year: 2012, Volume and Issue: 149(3), P. 656 - 670

Published: April 1, 2012

Language: Английский

Hallmarks of Cancer: The Next Generation DOI Creative Commons
Douglas Hanahan, Robert A. Weinberg

Cell, Journal Year: 2011, Volume and Issue: 144(5), P. 646 - 674

Published: March 1, 2011

Language: Английский

Citations

59953
Cancer Genome Landscapes DOI
Bert Vogelstein, Nickolas Papadopoulos, Victor E. Velculescu

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Science, Journal Year: 2013, Volume and Issue: 339(6127), P. 1546 - 1558

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Over the past decade, comprehensive sequencing efforts have revealed genomic landscapes of common forms human cancer. For most cancer types, this landscape consists a small number "mountains" (genes altered in high percentage tumors) and much larger "hills" infrequently). To date, these studies ~140 genes that, when by intragenic mutations, can promote or "drive" tumorigenesis. A typical tumor contains two to eight "driver gene" mutations; remaining mutations are passengers that confer no selective growth advantage. Driver be classified into 12 signaling pathways regulate three core cellular processes: cell fate, survival, genome maintenance. better understanding is one pressing needs basic research. Even now, however, our knowledge genomes sufficient guide development more effective approaches for reducing morbidity mortality.

Language: Английский

Citations

7295
The Emerging Hallmarks of Cancer Metabolism DOI Creative Commons
Natalya N. Pavlova, Craig B. Thompson

Cell Metabolism, Journal Year: 2016, Volume and Issue: 23(1), P. 27 - 47

Published: Jan. 1, 2016

Language: Английский

Citations

4772
Regulation of cancer cell metabolism DOI
Rob A. Cairns, Isaac S. Harris, Tak W. Mak

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Nature reviews. Cancer, Journal Year: 2011, Volume and Issue: 11(2), P. 85 - 95

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Language: Английский

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The Warburg Effect: How Does it Benefit Cancer Cells? DOI Creative Commons
Maria V. Liberti, Jason W. Locasale

Trends in Biochemical Sciences, Journal Year: 2016, Volume and Issue: 41(3), P. 211 - 218

Published: Jan. 5, 2016

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3956
The biology and function of fibroblasts in cancer DOI
Raghu Kalluri

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(9), P. 582 - 598

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Language: Английский

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Modulation of oxidative stress as an anticancer strategy DOI
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Nature Reviews Drug Discovery, Journal Year: 2013, Volume and Issue: 12(12), P. 931 - 947

Published: Nov. 29, 2013

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Otto Warburg's contributions to current concepts of cancer metabolism DOI
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Nature reviews. Cancer, Journal Year: 2011, Volume and Issue: 11(5), P. 325 - 337

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Mitochondria: In Sickness and in Health DOI Creative Commons
Jodi Nunnari, Anu Suomalainen

Cell, Journal Year: 2012, Volume and Issue: 148(6), P. 1145 - 1159

Published: March 1, 2012

Language: Английский

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2939
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate DOI Creative Commons
Patrick S. Ward, Craig B. Thompson

Cancer Cell, Journal Year: 2012, Volume and Issue: 21(3), P. 297 - 308

Published: March 1, 2012

Language: Английский

Citations

2935