Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(8), P. 524 - 532

Published: June 3, 2016

Language: Английский

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Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders

Australian & New Zealand Journal of Psychiatry, Journal Year: 2015, Volume and Issue: 49(12), P. 1087 - 1206

Published: Dec. 1, 2015

Objectives: To provide guidance for the management of mood disorders, based on scientific evidence supplemented by expert clinical consensus and formulate recommendations to maximise salience utility. Methods: Articles information sourced from search engines including PubMed EMBASE, MEDLINE, PsycINFO Google Scholar were literature known disorders committee (MDC) (e.g., books, book chapters government reports) published depression bipolar disorder guidelines. Information was reviewed discussed members MDC findings then formulated into consensus-based guidance. The guidelines subjected rigorous successive consultation external review involving: advisors, public, key stakeholders, professional bodies specialist groups with interest in disorders. Results: Royal Australian New Zealand College Psychiatrists practice (Mood Disorders CPG) up-to-date advice regarding that is informed experience. Mood CPG intended use psychiatrists, psychologists, physicians others an mental health care. Conclusions: Disorder first Clinical Practice Guideline address both depressive It provides within evidence-based framework, consensus. Committee: Professor Gin Malhi (Chair), Darryl Bassett, Philip Boyce, Richard Bryant, Paul Fitzgerald, Dr Kristina Fritz, Malcolm Hopwood, Bill Lyndon, Roger Mulder, Greg Murray, Porter Associate Ajeet Singh. International advisors: Carlo Altamura, Francesco Colom, Mark George, Guy Goodwin, McIntyre, Ng, John O’Brien, Harold Sackeim, Jan Scott, Nobuhiro Sugiyama, Eduard Vieta, Lakshmi Yatham. Marie-Paule Austin, Michael Berk, Yulisha Byrow, Helen Christensen, Nick De Felice, A/Professor Seetal Dodd, Megan Galbally, Josh Geffen, Hazell, David Horgan, Felice Jacka, Gordon Johnson, Anthony Jorm, Jon-Paul Khoo, Jayashri Kulkarni, Cameron Lacey, Noeline Latt, Florence Levy, Andrew Lewis, Colleen Loo, Thomas Mayze, Linton Meagher, Mitchell, Daniel O’Connor, Tim Outhred, Rowe, Narelle Shadbolt, Martien Snellen, Tiller, Watkins, Raymond Wu.

Language: Английский

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The resilience framework as a strategy to combat stress-related disorders

Nature Human Behaviour, Journal Year: 2017, Volume and Issue: 1(11), P. 784 - 790

Published: Oct. 13, 2017

Language: Английский

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Memory Engram Cells Have Come of Age

Neuron, Journal Year: 2015, Volume and Issue: 87(5), P. 918 - 931

Published: Sept. 1, 2015

Language: Английский

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A conceptual framework for the neurobiological study of resilience

Behavioral and Brain Sciences, Journal Year: 2014, Volume and Issue: 38

Published: Aug. 27, 2014

Abstract The well-replicated observation that many people maintain mental health despite exposure to severe psychological or physical adversity has ignited interest in the mechanisms protect against stress-related illness. Focusing on resilience rather than pathophysiology ways represents a paradigm shift clinical-psychological and psychiatric research great potential for development of new prevention treatment strategies. More recently, into also arrived neurobiological community, posing nontrivial questions about ecological validity translatability. Drawing concepts findings from transdiagnostic psychiatry, emotion research, behavioral cognitive neuroscience, we propose unified theoretical framework neuroscientific study general mechanisms. is applicable both animal human supports design interpretation translational studies. theory emphasizes causal role stimulus appraisal (evaluation) processes generation emotional responses, including responses stressors. On this basis, it posits positive (non-negative) style key mechanism protects detrimental effects stress mediates other known factors. Appraisal shaped by three classes – situation classification, reappraisal, interference inhibition can be investigated at neural level. Prospects future are discussed.

Language: Английский

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Animal models of major depression: drawbacks and challenges

Journal of Neural Transmission, Journal Year: 2019, Volume and Issue: 126(11), P. 1383 - 1408

Published: Oct. 4, 2019

Major depression is a leading contributor to the global burden of disease. This situation mainly related chronicity and/or recurrence disorder, and poor response antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating environment which rodents exposed (during developmental period or adulthood) biological underpinnings (i.e. gene deletion overexpression candidate genes, targeted lesions brain areas, optogenetic control specific neuronal populations, etc.). These manipulations can alter behavioural outcomes that be different symptomatic pathophysiological dimensions major depression. However, display substantial shortcomings contribute lack innovative pharmacological approaches recent decades hamper our capabilities investigate treatment-resistant Here, we discuss validity these models, review putative depression, subtypes recurrent Furthermore, identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical

Language: Английский

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Activating positive memory engrams suppresses depression-like behaviour

Nature, Journal Year: 2015, Volume and Issue: 522(7556), P. 335 - 339

Published: June 1, 2015

Language: Английский

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Diversity of Transgenic Mouse Models for Selective Targeting of Midbrain Dopamine Neurons

Neuron, Journal Year: 2015, Volume and Issue: 85(2), P. 429 - 438

Published: Jan. 1, 2015

Language: Английский

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Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility

Neuron, Journal Year: 2016, Volume and Issue: 90(5), P. 969 - 983

Published: May 12, 2016

Language: Английский

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Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

Molecular Psychiatry, Journal Year: 2020, Volume and Issue: 25(11), P. 2742 - 2758

Published: Feb. 21, 2020

Language: Английский

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