Nature Chemical Biology, Journal Year: 2023, Volume and Issue: 19(7), P. 846 - 854
Published: March 6, 2023
Language: Английский
Fungal Diversity, Journal Year: 2019, Volume and Issue: 97(1), P. 1 - 136
Published: July 1, 2019
Fungi are an understudied, biotechnologically valuable group of organisms. Due to the immense range habitats that fungi inhabit, and consequent need compete against a diverse array other fungi, bacteria, animals, have developed numerous survival mechanisms. The unique attributes thus herald great promise for their application in biotechnology industry. Moreover, can be grown with relative ease, making production at scale viable. search fungal biodiversity, construction living collection, both incredible economic potential locating organisms novel industrial uses will lead products. This manuscript reviews fifty ways which potentially utilized as biotechnology. We provide notes examples each exploitation give from our own work notable researchers. also flow chart used convince funding bodies importance biotechnological research provided world penicillin, lovastatin, globally significant medicines, they remain untapped resource enormous potential.
Language: Английский
Citations
676
Studies in Mycology, Journal Year: 2021, Volume and Issue: 98, P. 100116 - 100116
Published: March 1, 2021
Recent publications have argued that there are potentially serious consequences for researchers in recognising distinct genera the terminal fusarioid clade of family Nectriaceae. Thus, an alternate hypothesis, namely a very broad concept genus Fusarium was proposed. In doing so, however, significant body data supports Nectriaceae based on morphology, biology, and phylogeny is disregarded. A DNA 19 orthologous protein-coding genes presented to support at F1 node Here, we demonstrate re-analyses this dataset show all F3 represents sensu stricto as defined by F. sambucinum (sexual morph synonym Gibberella pulicaris). The backbone resolved concatenated alignment, but only six fully node, representing circumscription Fusarium. Furthermore, re-analysis revealed topologies different phylogenetic algorithms, highlighting deep divergence unresolved placement various lineages proposed members Species s. str. characterised sexual morphs, asexual morphs with thin- or thick-walled macroconidia variously shaped apical basal cells, trichothecene mycotoxin production, which separates them from other genera. Here Wollenweber presently accounts 20 segregate clear-cut synapomorphic traits, represent character has been gained lost multiple times throughout blurry without apparent synapomorphies, does not include fusarium-like macroconidia, spread (e.g., Cosmosporella, Macroconia, Microcera). study four new introduced, along 18 species 16 combinations. These names convey information about relationships, ecological preference would otherwise be broader definition To assist users correctly identify species, introduce online identification database, Fusarioid-ID, accessible www.fusarium.org. database comprises partial sequences commonly used taxa (act1, CaM, his3, rpb1, rpb2, tef1, tub2, ITS, LSU). paper, also present nomenclator introduced up January 2021 well their current status, types, diagnostic barcode data. study, 46 countries, taxonomists, plant pathologists, medical mycologists, quarantine officials, regulatory agencies, students, strongly application use more precisely delimited (= Gibberella) accommodate robust monophyletic basis well-defined unique combination morphological biochemical features. This includes, among others, fujikuroi, incarnatum-equiseti, oxysporum, complexes, Bisifusarium [F. dimerum complex (SC)], Cyanonectria (F. buxicola SC), Geejayessia staphyleae Neocosmospora solani SC) Rectifusarium ventricosum SC). first step generating monograph allied (www.fusarium.org).
Language: Английский
Citations
264
International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(11), P. 5723 - 5723
Published: May 26, 2021
Aquaculture is the productive activity that will play a crucial role in challenges of millennium, such as need for proteins support humans and respect environment. an important economic Mediterranean basin. A great impact presented, however, by aquaculture practices they involve use antibiotics treatment prophylaxis. As consequence aquaculture, antibiotic resistance induced surrounding bacteria column water, sediment, fish-associated bacterial strains. Through horizontal gene transfer, can diffuse antibiotic-resistance genes mobile further spreading genetic determinants. Once triggered, easily spreads among aquatic microbial communities and, from there, reach human pathogenic bacteria, making vain health. Climate change claims significant this context, rising temperatures affect cell physiology same way antibiotics, causing to begin with. The Sea represents ‘hot spot’ terms climate aspects area be significantly amplified, thus increasing threats Practices must adopted counteract negative impacts on health, with reduction pivotal point. In meantime, it necessary act against reducing anthropogenic impacts, example CO2 emissions into atmosphere. One Health type approach, which involves intervention different skills, veterinary, ecology, medicine compliance principles sustainability, strongly recommended face these animal environmental safety area.
Language: Английский
Citations
196
Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(19)
Published: May 3, 2021
Fungi are prolific producers of natural products, compounds which have had a large societal impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability over 1,000 fungal genomes several decades compound discovery efforts from fungi, biosynthetic gene clusters (BGCs) encoded by these associated chemical space yet to be analyzed systematically. Here, we provide detailed annotation analyses enable genome mining products. Using 1,037 species across kingdom (e.g., Ascomycota, Basidiomycota, non-Dikarya taxa), 36,399 predicted BGCs were organized into network 12,067 cluster families (GCFs). Anchoring GCFs with reference enabled automated 2,026 metabolite scaffolds. We performed parallel repertoire organizing 15,213 2,945 molecular (MFs). The taxonomic landscape is largely specific, though select such equisetin GCF present vast phylogenetic distances diversifications in MF. compare datasets set 5,453 bacterial their 9,382 compounds, revealing dramatic differences between logic space. These genomics cheminformatics reveal extent sources represent distinct reservoirs. With >10-fold increase number interpreted strains annotated BGCs, this work better regularizes potential fungi for rational discovery.
Language: Английский
Citations
134
Microbiome, Journal Year: 2021, Volume and Issue: 9(1)
Published: March 14, 2021
Abstract Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other microbiota, gut mycobiota plays an indispensable role modulating intestinal physiology. Notably, most striking characteristics of are their extraintestinal functions. Here, we provide comprehensive review importance regulation intestinal, pulmonary, hepatic, renal, pancreatic, brain functions, present possible opportunities for application to alleviate/treat human diseases.
Language: Английский
Citations
115
Fungal Diversity, Journal Year: 2023, Volume and Issue: 121(1), P. 95 - 137
Published: July 1, 2023
Abstract Fungi provide ecological and environmental services to humans, as well health nutritional benefits, are vital numerous industries. Fermented food beverage products from fungi circulating in the market, generating billions of USD. However, highest potential monetary value is their role blue carbon trading because ability sequester large amounts soil. There no conclusive estimates available on global fungi, primarily there limited data for extrapolation. This study outlines contribution economy provides a first attempt at quantifying fungi. Our estimate USD 54.57 trillion starting point that can be analysed improved, highlighting significance providing an appreciation value. paper identifies different economically valuable provided by By giving all important fungal products, services, industrial applications underscores biodiversity conservation. Furthermore, if established, they will considered future policies effective ecosystem management.
Language: Английский
Citations
100
Natural Product Reports, Journal Year: 2022, Volume and Issue: 39(8), P. 1557 - 1573
Published: Jan. 1, 2022
Covering: 2002 to 2020In their natural environment, fungi must compete for resources. It has been hypothesized that this competition likely induces the biosynthesis of secondary metabolites defence. In a quest discover new chemical diversity from fungal cultures, growing trend recapitulate competitive environment in laboratory, essentially co-culture. This review covers fungal-fungal co-culture studies beginning with first literature report 2002. Since then, there number reported as result studies. Specifically, discusses and provides insights into (1) rationale pairing strains, (2) ways grow co-culture, (3) different approaches screening co-cultures diversity, (4) determining metabolite-producing strain, (5) final thoughts regarding approach. Our goal is provide set practical strategies generate unique products research community can utilize.
Language: Английский
Citations
73
Fungal Diversity, Journal Year: 2024, Volume and Issue: 125(1), P. 1 - 71
Published: March 20, 2024
Abstract The field of mycology has grown from an underappreciated subset botany, to a valuable, modern scientific discipline. As this study grown, there have been significant contributions science, technology, and industry, highlighting the value fungi in era. This paper looks at current research, along with existing limitations, suggests future areas where scientists can focus their efforts, mycology. We show how become important emerging diseases medical discuss trends potential drug novel compound discovery. explore phylogenomics, its potential, outcomes address question phylogenomics be applied fungal ecology. In addition, functional genomics studies are discussed importance unravelling intricate mechanisms underlying behaviour, interactions, adaptations, paving way for comprehensive understanding biology. look research building materials, they used as carbon sinks, biocircular economies. numbers always great interest often written about estimates varied greatly. Thus, we needs order obtain more reliable estimates. aspects machine learning (AI) it mycological research. Plant pathogens affecting food production systems on global scale, such, needed area, particularly disease detection. latest data High Throughput Sequencing if still gaining new knowledge same rate before. A review nanotechnology is provided addressed. Arbuscular Mycorrhizal Fungi addressed acknowledged. Fungal databases becoming important, therefore provide major databases. Edible medicinal huge medicines, especially Asia prospects discussed. Lifestyle changes (e.g., endophytes, pathogens, and/or saprobes) also extremely trend special issue Diversity.
Language: Английский
Citations
38
Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical
Language: Английский
Citations
5
Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(2), P. 93 - 93
Published: Jan. 24, 2025
Metabolomics has emerged as a transformative tool in the study of microbes, including pathogenic fungi, facilitating identification unique metabolic profiles that elucidate their mechanisms, host interactions, and treatment resistance. This review highlights key applications metabolomics understanding fungal metabolites essential for human virulence, such mycotoxins produced by various species, Aspergillus fumigatus (gliotoxin, fumagillins) Candida species (phenylethyl alcohol, TCA cycle metabolites), secondary contribute to pathogenicity. It also explores adaptations fungi relation drug resistance biofilm formation, revealing alterations pathways during infection, seen C. albicans auris. Furthermore, aids deciphering host–pathogen showcasing how like Cryptococcus neoformans modify metabolism promote survival evade immune responses. The antifungal mechanisms benefited from metabolomic approaches, identifying specific metabolite patterns signify resistance, Candidozyma (Candida) auris, informing new therapeutic strategies. integration with other omics technologies is paving way comprehensive biology pathogenesis. Such multi-omics approaches are crucial discovering targets developing innovative treatments. Thus, purpose this provide an overview revolutionizing our pathogenesis, highlight its potential improving
Language: Английский
Citations
4