Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(6), P. 723 - 723
Published: June 18, 2024
Wound
infections
may
disrupt
the
normal
wound-healing
process.
Large
amounts
of
antibiotics
are
frequently
used
to
prevent
pathogenic
infections;
however,
this
can
lead
resistance
development.
Biomaterials
possessing
antimicrobial
properties
have
promising
applications
for
reducing
antibiotic
usage
and
promoting
wound
healing.
Silk
sericin
(SS)
has
been
increasingly
explored
skin
healing
owing
its
excellent
biocompatibility
antioxidant,
antimicrobial,
ultraviolet-resistant
properties.
In
recent
years,
SS-based
composite
biomaterials
with
a
broader
spectrum
extensively
investigated
demonstrated
favorable
efficacy
in
This
review
summarizes
various
agents,
including
metal
nanoparticles,
natural
extracts,
antibiotics,
that
incorporated
into
SS
composites
elucidates
their
mechanisms
action.
It
revealed
achieve
sustained
activity
by
slow-release-loaded
agents.
The
antimicrobial-loaded
promote
through
anti-infection,
anti-inflammation,
hemostasis,
angiogenesis,
collagen
deposition.
manufacturing
methods,
benefits,
limitations
materials
briefly
discussed.
aims
enhance
understanding
new
advances
directions
guide
future
biomedical
research.
Small,
Journal Year:
2024,
Volume and Issue:
20(29)
Published: Feb. 20, 2024
As
the
global
population
ages,
bone
diseases
have
become
increasingly
prevalent
in
clinical
settings.
These
conditions
often
involve
detrimental
factors
such
as
infection,
inflammation,
and
oxidative
stress
that
disrupt
homeostasis.
Addressing
these
disorders
requires
exogenous
strategies
to
regulate
osteogenic
microenvironment
(OME).
The
regulation
of
OME
can
be
divided
into
four
processes:
induction,
modulation,
protection,
support,
each
serving
a
specific
purpose.
To
this
end,
metal-organic
frameworks
(MOFs)
are
an
emerging
focus
nanomedicine,
which
show
tremendous
potential
due
their
superior
delivery
capability.
MOFs
play
numerous
roles
metal
ion
donors,
drug
carriers,
nanozymes,
photosensitizers,
been
extensively
explored
recent
studies.
This
review
presents
comprehensive
introduction
by
MOF-based
nanomaterials.
By
discussing
various
functional
MOF
composites,
work
aims
inspire
guide
creation
sophisticated
efficient
nanomaterials
for
disease
management.
Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(8)
Published: Feb. 29, 2024
Staphylococcus
aureus
is
a
leading
cause
of
biofilm-associated
prosthetic
joint
infection
(PJI).
A
primary
contributor
to
chronicity
an
expansion
granulocytic
myeloid-derived
suppressor
cells
(G-MDSCs)
that
are
critical
for
orchestrating
the
anti-inflammatory
biofilm
milieu.
Single-cell
sequencing
and
bioinformatic
metabolic
algorithms
were
used
explore
link
between
G-MDSC
metabolism
S.
PJI
outcome.
Glycolysis
hypoxia
response
through
hypoxia-inducible
factor-1
alpha
(HIF-1a)
significantly
enriched
in
G-MDSCs.
Interfering
with
both
pathways
vivo,
using
2-deoxyglucose
nanopreparation
granulocyte-targeted
HIF-1a
conditional
knockout
mice,
respectively,
attenuated
G-MDSC-mediated
immunosuppression
reduced
bacterial
burden
mouse
model
PJI.
In
addition,
scRNA-seq
analysis
granulocytes
from
patients
also
showed
enrichment
glycolysis
genes.
These
findings
support
importance
glycolysis/HIF-1a
axis
promoting
activity
persistence
during
Staphylococcus
aureus
produces
a
variety
of
exotoxins,
which
are
important
virulence
factors
for
S.
aureus-related
diseases.
Representatively,
staphylococcal
enterotoxins
induce
food-born
poisoning;
toxic
shock
syndrome
toxin-1,
is
typical
superantigen,
induces
syndrome;
hemolysins
cell
damages
erythrocyte
and
leukocyte;
exfoliative
toxin
skin
scalded
syndrome.
Recently,
cytotoxin,
Panton-Valentine
leukocidin
produced
by
community-associated
MRSA
noticeable.
This
chapter
addresses
novel
information
in
activities
stability
the
exotoxins
aureus.
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: May 28, 2024
Bovine
mastitis
is
one
of
the
most
common
diseases
dairy
cattle.
Even
though
different
infectious
microorganisms
and
mechanical
injury
can
cause
mastitis,
bacteria
are
in
cows.
Staphylococci,
streptococci,
coliforms
frequently
diagnosed
etiological
agents
Staphylococci
that
broadly
divided
into
Staphylococcus
aureus
non-aureus
staphylococci
(NAS).
NAS
mainly
comprised
coagulase-negative
species
(CNS)
some
coagulase-positive
coagulase-variable
staphylococci.
Current
staphylococcal
control
measures
ineffective,
dependence
on
antimicrobial
drugs
not
sustainable
because
low
cure
rate
with
treatment
development
resistance.
Non-antimicrobial
effective
tools
critically
needed.
This
review
describes
current
status
S.
cows
flags
areas
knowledge
gaps.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(6), P. 723 - 723
Published: June 18, 2024
Wound
infections
may
disrupt
the
normal
wound-healing
process.
Large
amounts
of
antibiotics
are
frequently
used
to
prevent
pathogenic
infections;
however,
this
can
lead
resistance
development.
Biomaterials
possessing
antimicrobial
properties
have
promising
applications
for
reducing
antibiotic
usage
and
promoting
wound
healing.
Silk
sericin
(SS)
has
been
increasingly
explored
skin
healing
owing
its
excellent
biocompatibility
antioxidant,
antimicrobial,
ultraviolet-resistant
properties.
In
recent
years,
SS-based
composite
biomaterials
with
a
broader
spectrum
extensively
investigated
demonstrated
favorable
efficacy
in
This
review
summarizes
various
agents,
including
metal
nanoparticles,
natural
extracts,
antibiotics,
that
incorporated
into
SS
composites
elucidates
their
mechanisms
action.
It
revealed
achieve
sustained
activity
by
slow-release-loaded
agents.
The
antimicrobial-loaded
promote
through
anti-infection,
anti-inflammation,
hemostasis,
angiogenesis,
collagen
deposition.
manufacturing
methods,
benefits,
limitations
materials
briefly
discussed.
aims
enhance
understanding
new
advances
directions
guide
future
biomedical
research.
