Broadening oncological boundaries: the intratumoral microbiota

Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(8), P. 807 - 822

Published: Feb. 3, 2024

The microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms the intratumoral affect tumorigenesis progression, suggesting is a promising biomarker for multiple cancers. low biomass poses major challenge to related research, thus necessitating use multiple-modality integrated framework resolve this dilemma. Advanced techniques such as single-cell sequencing provide significant clues, gradual optimization experiments culture-based methods enables deeper investigation underlying involved. In review, we outline current state research on describe challenges comprehensive strategies future research.

Language: Английский

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Intratumoral microbiota: implications for cancer onset, progression, and therapy

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.

Language: Английский

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Tumor-resident microbes: the new kids on the microenvironment block

Trends in cancer, Journal Year: 2024, Volume and Issue: 10(4), P. 347 - 355

Published: Feb. 22, 2024

Tumor-resident microbes (TRM) are an integral component of the tumor microenvironment (TME). TRM can influence growth, distant dissemination, and response to therapies by interfering with molecular pathways in cells as well other components TME. Novel technologies improving identification visualization cell type-specific The mechanisms that mediate role at primary tumors metastatic sites being elucidated. This knowledge is providing novel perspectives for targeting or using microbial interventions cancer interception therapy.

Language: Английский

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Multi-omics analysis elucidates the relationship between intratumor microbiome and host immune heterogeneity in breast cancer

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(4)

Published: March 5, 2024

Research has indicated that intratumor microbiomes affect the occurrence, progression, and therapeutic response in many cancer types by influencing immune system. We aim to evaluate characteristics of immune-related (IRIMs) breast (BC) search for potential prognosis prediction factors treatment targets. The clinical information, microbiome data, transcriptomics data Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) patients were obtained from Kraken-TCGA-Raw-Data TCGA portal. core tumor-infiltrating cell was identified using univariate Cox regression analysis. Based on consensus clustering analysis, BC categorized into two subtypes, referred as immune-enriched immune-deficient subtypes. subtype, characterized higher levels infiltration CD8+ T macrophage M1 cells, demonstrated a more favorable prognosis. Furthermore, significant differences alpha-diversity beta-diversity observed between least discriminant analysis effect size method 33 IRIMs. An microbiome-based prognostic signature consisting four IRIMs (Acidibacillus, Succinimonas, Lachnoclostridium, Pseudogulbenkiania) constructed proportional-hazard model, it had great value. correlated with gene expression sensitivity chemotherapy drugs, specifically tamoxifen docetaxel. In conclusion, our research successfully distinct subtypes BC, which exhibit contrasting prognoses possess unique epigenetic microbiomes. critical prognosis, abundance, immunotherapeutic efficacy BC. Consequently, this study biomarkers, providing novel approach treating BC.IMPORTANCERecent substantiated presence tumor microenvironment, could influence occurrence well provide new opportunities diagnosis treatment. This Pseudogulbenkiania), might be target regulate immunotherapy

Language: Английский

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Leveraging the intratumoral microbiota to treat human cancer: are engineered exosomes an effective strategy?

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 5, 2024

Cancer remains a leading cause of global mortality. The tumor microbiota has increasingly been recognized as key regulator cancer onset and progression, in addition to shaping responses immunotherapy. Microbes, including viruses, bacteria, fungi, other eukaryotic species can impact the internal homeostasis health humans. Research focused on gut microflora intratumoral microbiome revolutionized current understanding how tumors grow, progress, resist therapeutic interventions. Even with this research, however, there relatively little that is known respect abundance microbes their effects microenvironment. Engineered exosomes are class artificial extracellular nanovesicles actively transport small molecule drugs nucleic acids, which have broad prospects cell therapy. present review offers an overview recent progress challenges associated engineered context research. These discussions used inform construction novel framework for exosome-mediated targeted drug delivery, taking advantage diversity strategic asset thereby providing new opportunities more effectively treat manage clinic.

Language: Английский

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Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Sept. 26, 2023

Abstract The polymorphic microbiome has been proposed as a new hallmark of cancer. Intratumor revealed to play vital roles in regulating tumor initiation and progression, but the regulatory mechanisms have not fully uncovered. In this review, we illustrated that similar other components microenvironment, reside composition intratumor are regulated by cells surrounding microenvironment. hypoxic, immune suppressive, highly permeable microenvironment may select certain microbiomes, directly interact with via molecular binding or secretions. Conversely, microbiomes plays progression mutational landscape, function genes modulating including immunity, inflammation, angiogenesis, stem cell niche, etc. Moreover, is anti‐cancer therapies actively influences therapy response, which could be therapeutic target engineered weapon clinic. This review highlights component uncovers potential mutual between microbiome, points out ongoing research directions drawbacks area, should broaden our view enlighten further investigation directions.

Language: Английский

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Devosia alba sp. nov., a potential nitrite-reducing bacterium isolated from a mudflat

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(3)

Published: Feb. 7, 2025

Language: Английский

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Unveiling the microbial influence: bacteria’s dual role in tumor metastasis

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

As cancer research advances, the intricate relationship between microbiome and is gaining heightened recognition, especially concerning tumor metastasis, where bacterial involvement becomes increasingly complex. This review seeks to systematically examine dual roles of bacteria in metastasis process, encompassing both mechanisms that facilitate inhibitory effects exerted by specific microorganisms. We explore through which influence cell migration inducing chronic inflammation, evading host immune responses, remodeling ECM. Moreover, immunomodulatory potential probiotics genetically engineered offers promising prospects for prevention treatment metastasis. article elucidates complexity emerging frontiers examining clinical significance as biomarkers evaluating antibiotic usage on metastatic process. posit comprehending biological characteristics bacteria, a critical component microenvironment, will offer innovative strategies theoretical foundations treatment. Furthermore, this explores future directions, including application technologies bacteria-based therapeutic strategies, thereby offering valuable perspective development novel anti-cancer approaches.

Language: Английский

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Altered Bacteria Abundance Is Associated With Outcomes in Head and Neck Squamous Cell Carcinoma

Otolaryngology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Objective To determine if microbiome differences exist in head and neck squamous cell carcinoma (HNSCC) based on high‐risk pathologic features, smoking, outcomes using The Cancer Microbiome Atlas (TCMA). Study Design Database study. Setting review. Methods TCMA is a publicly available database containing curated, decontaminated microbial profiles for tumors from 1772 patients. data were limited to profiles, survival, clinicopathologic features HNSCC Phyloseq objects created, low‐read samples removed, differential abundance analysis (DAA) Analysis of Compositions Microbiomes with Bias Correction 2 (ANCOM‐BC2) was performed. Statistical done R (v4.3.1). Results One hundred fifty‐six patients included mean age 59 (std 13, min 19, max 90), 72% male (n = 113), 91% white 140). Primary sites encompassed oral cavity 106, 68%), oropharynx 26, 17%), larynx/hypopharynx 24, 15%). For all TCMA, rates lymphovascular invasion 17% 26), perineural invasion, 34% 53), microscopic or gross extranodal extension (ENE), 19% 30). DAA revealed significant changes bacterial genera smoking status, vital disease‐specific survival (DSS). Genera observed ANCOM‐BC2 include Scardovia , Alloscardovia Lactobacillus Corynebacterium status DSS. Conclusion Changes the relative select intratumoral are associated adverse DSS, HNSCC. Shifts need further investigation they can provide any mechanistic insight predictive role.

Language: Английский

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Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(8)

Published: April 1, 2025

ABSTRACT Background Microsatellite instability (MSI) is a hallmark of DNA mismatch repair (MMR) deficiency that leads to genomic and increased cancer risk. The tumor microenvironment (TME) significantly influences MSI‐driven tumorigenesis, emerging evidence points critical role the microbiome in shaping this complex interplay. Methods This review comprehensively examines existing literature on intricate relationship between MSI, microbiome, development, with particular focus impact microbial dysbiosis TME. Results MSI‐high tumors exhibited immune cell infiltration owing generation neoantigens. However, evasion mechanisms such as PD‐1/CTLA‐4 upregulation limit efficacy checkpoint inhibitors (ICIs) subset patients. Pathobionts, Fusobacterium nucleatum Bacteroides fragilis, contribute MSI through production genotoxins, further promoting inflammation oxidative stress within Conclusions profoundly affects tumorigenesis. Modulation gut microbiota interventions fecal transplantation, probiotics, dietary changes holds promise for improving ICI response rates. Further research into pharmacomicrobiomics, investigating interplay metabolites anticancer therapies, crucial developing personalized treatment strategies.

Language: Английский

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