The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 17, 2025

This study aimed to investigate the potential relationship between newly defined adiposity metric, Body Roundness Index (BRI), which assesses central obesity, and development of new-onset hyperuricemia. In Kailuan cohort from 2006 2019, 91,804 eligible participants were included. A multivariate Cox regression model was used test correlation BRI At same time, restricted cubic spline applied solve dose-response risk hyperuricemia.Then, stratified analysis carried out using according age, sex, hs-CRP level, TG education smoking status hypertension status. The results showed that hyperuricemia significantly increased in highest quartile compared with lowest quartile. After adjusting for confounders, Q1, HR (95% CI) 1.24 (1.18–1.30), 1.32 (1.25–1.40), 1.40 (1.29–1.52) Q2, Q3, Q4, respectively. Restricted a J-curve baseline levels hyperuricaemia. Age, income smoking, each had multiplicative interaction at baseline. We found elevated developing addition, association dependency on

Language: Английский

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Correlation between Neutrophil-to-Lymphocyte Ratio, Platelets-to-Lymphocyte Ratio, C-Reactive Protein-to-Albumin Ratio and Clinical Picture of Elderly Chronic Heart Failure Patients

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 433 - 433

Published: Jan. 12, 2024

Neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte (PLR) and C-reactive protein-to-albumin (CAR) are believed to be potential inflammatory markers that closely related the prognosis course of cardiovascular diseases. The main goal this study was evaluation NLR, PLR CAR as factors reflecting clinical picture elderly chronic heart failure (CHF) patients. In 150 patients with newly diagnosed CHF, were correlated cardiac, laboratory nutritional parameters. Systemic ratios selected patient's associated an unfavorable CHF-a reduced EF (p = 0.007), elevated PASP 0.014), increased LVESD in both males females 0.032 0.024, respectively) a decreased TAPSE 0.023). allowed us distinguish between NYHA I-III IV classes AUC 0.830. By analyzing five-year mortality rate different values, greater death recorded for high values-one-year (40.3% vs. 17.2%) (80% 58.3%) 0.002). Both NLR only An analysis markers, mainly CAR, allows management because its value can reflect cardiac status prognostic value. serve supplementary examinations evaluation.

Language: Английский

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Evaluation of the Prognostic Role of Neutrophil-Lymphocyte Ratio, C-Reactive Protein-Albumin Ratio, and Platelet-Lymphocyte Ratio in Patients with the Co-Presentation of Coronary Artery Disease and COVID-19

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 885 - 897

Published: March 1, 2024

Aim: The purpose of this study was to investigate the role neutrophil-lymphocyte ratio (NLR), C-reactive protein-albumin (CAR), and platelet-lymphocyte (PLR) in prognosis patients with coronary artery disease (CAD) complicated coronavirus 2019 (COVID-19). Methods: This included 265 patients. A receiver operating characteristic (ROC) curve analysis performed preliminarily evaluate predictive ability NLR, CAR, PLR for all-cause death. primary outcome death during hospitalization, while secondary outcomes were cardiovascular respiratory failure Cox proportional hazard model adjusted covariates used analyze cumulative risk outcomes. We also conducted subgroup analyses based on acute chronic characteristics CAD. Propensity score matching (PSM) further robustness outcome. Results: ROC results showed that area under (AUC) values 0.686 (95% CI 0.592– 0.781, P< 0.001) 0.749 0.667– 0.832, 0.571 0.455– 0.687, P=0.232) PLR. trends NLR did not affect (P=0.096 P=0.544 trend, respectively), but a higher CAR level corresponded (P< 0.001 trend). Similarly, death, PSM consistent total cohort. Conclusion: In CAD COVID-19, not. Keywords: disease, 2019, ratio,

Language: Английский

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High C-reactive protein-to-albumin ratio levels are associated with osteoporosis in patients with primary biliary cholangitis

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Inflammation contributes to the development of metabolic bone diseases. The C-reactive protein-to-albumin ratio (CAR) is an inflammation-based marker with a prognostic value for several This study investigated relationship between CAR and osteoporosis (OP) in patients primary biliary cholangitis (PBC).

Language: Английский

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Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 9, 2024

Systemic inflammation significantly increases the risk of short- and long-term mortality in geriatric hospitalized patients. To predict older patients with various age-related diseases infections, including COVID-19, inflammatory biomarkers such as C-reactive protein (CRP) to albumin ratio (CAR), related scores indexes, i.e. Glasgow Prognostic Score (GPS), modified GPS (mGPS), high sensitivity (hs)-mGPS, have been increasingly utilized. Despite their easy affordability widespread availability, these are predominantly assessed for clinical purposes rather than predictive applications, leading underutilization In this study, we investigated association CAR, GPS, mGPS, hs-mGPS short-term 3,206 admitted acute conditions, irrespective admission diagnosis. We observed that unit highest classes were associated a two- threefold increased death, even adjusting different confounding variables. Interestingly, 2 showed effect size. Furthermore, gender analysis indicated stronger between all CRP-albumin based parameters men, underscoring gender-specific relevance inflammation-based circulating prediction. conclusion, on serum CRP levels offer additional guidance stratification in-hospital by providing information degree systemic inflammation.

Language: Английский

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Association between C-reactive protein to albumin ratio and chronic obstructive pulmonary disease: a cross-sectional study

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 2, 2025

Chronic obstructive pulmonary disease (COPD) is a widespread condition that significantly endangers human health. The C-reactive protein to albumin ratio (CAR) has been utilized as an important marker for the occurrence and development of various diseases. Nevertheless, association between CAR COPD remains inadequately explored. This research aimed examine link COPD. cross-sectional study examined data from adult participants in National Health Nutrition Examination Survey 1999 2010. identification relied on obtained directly self-reported information. Logistic regression analysis was used estimate odds (OR) 95% confidence interval (CI) Additionally, subgroup sensitivity analyses were performed evaluate stability observed relationship. comprised 24,627 participants, among whom 1,809 had After adjusting potential confounders, found be associated with (OR 1.37; CI, 1.12–1.69; P = 0.003). In comparing individuals lowest tertile (T1) those highest, adjusted OR 1.39 (95% 1.17–1.65; < 0.001). Validation through further strengthened consistency study's findings. Elevated levels correlated increased risk : not applicable.

Language: Английский

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Relationship between platelet distribution width and non-dipping pattern in children with essential hypertension

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 22, 2025

Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated clinical characteristics risk factors non-dipper status essential hypertension children. This study aimed to explore possible indicators children A total 125 (99 boys, 26 girls) untreated were retrospectively included this study. Non-dipping was defined as nocturnal drop systolic or diastolic BP (SBP, DBP) < 10%. Clinical data, ambulatory blood pressure monitoring (ABPM), laboratory echocardiography parameters recorded from hospital database. found 74 (59.2%) dipping 51(40.8%) children, SBP 8.43 ± 0.71 (%), DBP 14.44 0.86 (%). The proportion left ventricular hypertrophy higher group than group. platelet distribution width, high-sensitivity C-reactive protein (hs-CRP) triglycerides (TG) levels compared In multivariate logistic regression analysis, PDW, TG hs-CRP be pattern. common, Moreover, are for

Language: Английский

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C-reactive protein to albumin ratio as a prognostic marker in community-acquired pneumonia mortality

Turkish Journal of Clinics and Laboratory, Journal Year: 2025, Volume and Issue: 16(1), P. 180 - 185

Published: March 25, 2025

Aim: This study aimed to evaluate the prognostic value of C-reactive protein-to-albumin ratio (CAR) in predicting 30-day mortality among patients diagnosed with community-acquired pneumonia (CAP) presenting emergency department (ED). Material and Methods: A retrospective was conducted on 312 CAP who presented ED a tertiary care hospital between January 1, 2022, 2024. Demographic, clinical, laboratory data were collected, including protein (CRP) albumin levels. CAR calculated by dividing CRP levels (mg/dL) (g/L). The primary outcome mortality. performance evaluated using receiver operating characteristic (ROC) curve analysis. Results: Of included, 87 (27.9%) died within 30 days. deceased group had significantly higher values compared survivors (1.18 ± 0.62 vs. 0.52 0.25, p < 0.001). demonstrated excellent discriminatory power for mortality, an area under (AUC) 0.837 (95% CI: 0.791–0.876, At cut-off >0.77, achieved sensitivity 75.9% specificity 86.7%. Deceased also exhibited lower systolic diastolic blood pressures, oxygen saturation, levels, along respiratory rates. Comorbidities such as stroke congestive heart failure more prevalent survivors. Conclusion: is reliable marker ED. Its ease calculation strong make valuable tool risk stratification clinical decision-making. Prospective studies are warranted confirm these findings diverse populations.

Language: Английский

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The comprehensive effects of high-sensitivity C-reactive protein and triglyceride glucose index on cardiometabolic multimorbidity

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

The triglyceride-glucose index (TyG index) is one of the surrogate markers insulin resistance, and high-sensitivity C-reactive protein (hsCRP) reflects systemic inflammation. Existing studies suggest that resistance or inflammation may be indicative cardiometabolic disease, but few existing have combined TyG levels before assessing multimorbidity. Our study data came from China Health Retirement Longitudinal Study (CHARLS). Participants in this were followed for 9 years, we used these to conduct a long-term analysis assess effects hsCRP on multimorbidity Chinese adults over 45 years age. To effect middle-aged as well elderly Chinese. (CHARLS), which included total 4,483 participants who did not cardiovascular metabolic diseases at baseline, was CHARLS 2011, last survey 2020. A five considered study: diabetes, hypertension, hyperlipidemia, heart disease stroke. person defined having when he/she had two more same time. (median cut-off) (1mg/L each divided into groups four (Group L-L: index=median L-H: hsCRP>=1mg/L; H-H: hsCRP>=1mg/L). Multiple regression equations fitted analyse influence increases risk CMM events independently hsCRP, does reverse. When elevated also elevated, condition significantly danger High can enhance people, joint use assessment better way achieve primary prevention people.

Language: Английский

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C-reactive protein-to-albumin ratio is associated with mortality after transcatheter tricuspid valve repair

Clinical Research in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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