Relationship between physical activity and DNA methylation-predicted epigenetic clocks DOI Creative Commons
Yanwei You, Yuquan Chen, Hao Ding

et al.

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 12, 2025

This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight were analyzed, revealing that higher PA significantly associated with younger biological ages across all indicators, strongest effects observed for SkinBloodAge LinAge. Multivariable linear regression models, adjusted sociodemographic lifestyle factors, highlighted potential of to reduce ageing. Subgroup analyses indicated these associations more pronounced among non-Hispanic whites, individuals BMI 25-30, former smokers, suggesting impact varies different groups. These findings emphasize role slowing ageing reducing age-related health risks. Promoting regular PA, especially older adults those BMI, could improve well-being lifespan, highlighting as modifiable factor healthy disease prevention.

Language: Английский

Accelerometer-measured physical activity and sedentary behaviour are associated with C-reactive protein in US adults who get insufficient sleep: A threshold and isotemporal substitution effect analysis DOI
Yanwei You

Journal of Sports Sciences, Journal Year: 2024, Volume and Issue: 42(6), P. 527 - 536

Published: March 18, 2024

This study aimed to investigate the association between physical activity, sedentary behaviour and chronic inflammation in short sleep adults. The included 2,113 NHANES participants with self-reported insufficient sleep. C-reactive protein (CRP) was used as inflammatory biomarker. Physical activity were objectively measured by accelerometers. Weighted regression model, two – piecewise linear restricted cubic splines applied evaluate associations mentioned above. An isotemporal substitution model assess modelled effects of replacing time (ST) moderate-to-vigorous levels (MVPA) or light (LPA). After adjusting for potential confounding factors, higher ST lower LPA MVPA associated CRP levels. Isotemporal analysis indicated that 30 minutes a significant decrease Saturation suggested may plateau at over 20 per day. Findings this provides insight into benefits MVPA. also suggests increasing beyond certain point not provide additional anti-inflammatory population.

Language: Английский

Citations

54
Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies DOI Creative Commons
Yanwei You, Jinwei Li, Yang Zhang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Aims The molecular mechanism of short‐sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011–2014) explore cellular mechanisms mice. Methods Systemic immune‐inflammation index (SII) was calculated using blood‐cell based biomarkers. Further, we employed integrated bioinformatics single‐cell transcriptomics (GSE137665) examine how sleep exposure influenced pathways associated with inflammation brain. To signaling biological processes deprivation, carried out enrichment analyses utilizing GO KEGG databases. Results Population results showed that, compared normal group, severe lower ability all four tests. Moreover, a higher SII level correlated scores In mice study, elevated activation pathway observed cell subgroups neurons within deprivation recovery cohorts. Additionally, heightened expression oxidative stress response noted GABAergic during deprivation. Conclusion study contributed understanding influence its mechanisms.

Language: Английский

Citations

46
Saturation effects of the relationship between physical exercise and systemic immune inflammation index in the short-sleep population: a cross-sectional study DOI Creative Commons
Yanwei You, Alimjan Ablitip, Yuquan Chen

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 17, 2024

Abstract Background Short sleep can lead to an increase in inflammation and regular exercise has been shown have a mitigation effect. However, the association between physical (PE) short population is unknown intriguing issue. Methods NHANES dataset spanning years 2007 2018 were analyzed. To investigate relationship mentioned above, we carried out multivariate linear regression models controlling for sociodemographic lifestyles factors. The systemic immune index (SII) served as reflection of inflammatory potential, calculated product platelet count, neutrophil divided by lymphocyte count. Self-reported questionnaires used collect information. Results A total 14,664 participants included final analysis. Across three models, PE showed significant negative associations with SII continuous variable [Crude Model, β (95% CI): -1.261(-1.600, -0.922), p < 0.001; Model 1, -1.005(-1.344, -0.666), 2, -0.470(-0.827, -0.112), = 0.011]. consistent nature findings persisted when investigating categorized variable. By two-piecewise model, saturation effect inflection point 2400 MET-minutes/week. Conclusion This study suggested that performing no more than MET-minutes/week was associated lower levels population, while might not bring additional benefits.

Language: Английский

Citations

37
Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions DOI Creative Commons
Ioulia Barakou, Bregje L. Seves, Ulric S. Abonie

et al.

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 28, 2025

Language: Английский

Citations

3
Physical activity and mental health: a systematic review and best-evidence synthesis of mediation and moderation studies DOI Creative Commons
Rhiannon Lee White, Stewart A. Vella, Stuart Biddle

et al.

International Journal of Behavioral Nutrition and Physical Activity, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 28, 2024

Abstract Background While evidence consistently demonstrates that physical activity is beneficial to mental health, it remains relatively unknown how benefits and which factors influence the effect of on health. This understanding could vastly increase our capacity design, recommend, prescribe in more optimal ways. The purpose this study was systematically review synthesise all mediators moderators relationship between Methods Systematic searches four databases (i.e., Scopus, PsycINFO, PubMed, SPORTDiscus) identified 11,633 initial studies. Empirical studies quantitatively assessed activity, or conducted a intervention, measured health outcome, tested one mediator moderator were included. A total 247 met inclusion criteria; 173 examined mediation 82 moderation. Results best-evidence synthesis revealed strong for 12 including affect, wellbeing, self-esteem, self-efficacy, self-worth, body image satisfaction, resilience, social support, connection, pain, fatigue. Moderate further 15 eight moderators. Conclusions Findings should inform design future interventions ensure effects related outcomes. Additionally, if professionals take these into consideration when prescribing recommending would likely have greater impact population

Language: Английский

Citations

13
Exploration of physical activity, sedentary behavior and insulin level among short sleepers DOI Creative Commons
Yuquan Chen, Yanwei You,

Mengxian Wei

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

Sufficient physical activity and sleep duration are essential for overall health. While one-third of the US population reports short (<7 h), which is proven to link with negative health status. Current evidence on relationship between activity, sedentary behavior, serum insulin level in groups limited.

Language: Английский

Citations

8
Correlation between hepatic steatosis severity diagnosed by ultrasound and metabolic indexes in elderly patients with MAFLD DOI Creative Commons
Zhiyong Liang, Rong Huang, Lingyun Zhang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

To explore the connection between metabolic parameters and severity of hepatic steatosis determined through ultrasound in elderly individuals with dysfunction-associated fatty liver disease (MAFLD). 4,663 senior who were 65 years age or older included this research. They examined physically at Ninghai Street Community Health Service Center Yantai City June 7, 2021, October 15, 2021. There two categories identified: MAFLD group (n = 2,985) non-MAFLD 1,678). Based on ultrasonography results, further separated into three groups: mild 2,104), moderate 766), severe 115). identify indicators risk for steatosis, data was contrasted groups employing logistic regression. In comparison to group, showed significantly elevated levels body mass index (BMI), blood pressure, gender, age, lipid profile, alanine transaminase (ALT), fasting glucose (FBG; p < 0.05). Among MAFLD, there a positive correlation BMI, FBG, ALT, aspartate (AST) (p Logistic regression analysis indicated that female triglycerides (TG), serum uric acid (SUA) constituted factors increased MAFLD. The patients is correlated TG, SUA.

Language: Английский

Citations

1
Impact of combiner aerobic and resistance training on depression: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Wang Hai, Qing Liu,

Yingxu Pan

et al.

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 23, 2025

To summarize the existing literature and evaluate efficacy of combined resistance aerobic training in alleviating depressive symptoms among individuals with depression. Subgroup analyses were conducted based on study region, age, depression severity, intervention duration, frequency, whether was supervised or unsupervised. Five databases thoroughly examined from database establishment until August 20, 2024, to find randomized controlled trials that investigated impact Finally, 27 eligible studies included, involving a total 2,342 patients The outcomes indicated notably improved signs these (SMD=-1.39, 95%CI=-1.80 -0.96, p = 0.000). analysis area, severity symptoms, exercise prescription revealed had particularly significant effect middle-aged elderly depression, as well those moderate Additionally, period (9–24 weeks), frequency (3–4 times per week), weekly duration more than 180 min displayed best results. Resistance serves an efficient approach relieve depression-related Moderate intensity, offer greatest benefit.

Language: Английский

Citations

1
Health in Spanish older people: Dietary habits, lifestyles and related socioeconomic factors DOI Creative Commons
Elisa Amo-Saus, Isabel Pardo García,

Ana Pilar Martínez-Valero

et al.

Preventive Medicine Reports, Journal Year: 2025, Volume and Issue: 51, P. 102995 - 102995

Published: Jan. 31, 2025

Language: Английский

Citations

1
Mediation Role of Telomere Length in the Relationship between Physical Activity and PhenoAge: A Population-based Study DOI Creative Commons
Yanwei You,

Dizhi Wang,

Hao Ding

et al.

Journal of Exercise Science & Fitness, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research. study encompassed cohort 6200 participants aged 20 years above, sourced from the National Health Nutrition Examination Survey (NHANES). Physical (PA) levels were assessed employing Global Activity Questionnaire, while DNA samples collected to determine measured base pairs. PhenoAge, an emerging index relying on nine distinct chemical biomarkers, was computed. Incorporating fully adjusted model, our analysis showed significant correlations PA engagement PhenoAge [Low PA, β (95 % CI): 0.039(-0.071,-0.008), p = 0.021; Moderate 0.058(-0.082,-0.034), < 0.001; High 0.069(-0.096,-0.042), 0.001]. Furthermore, positive link emerged elevated with CI) 0.011(0.001, 0.022), 0.034. A mediation performed, demonstrating that length mediated connection proportion calculated at 3.57 %. Our findings suggest may play key role mitigating processes by preserving highlighting potential as target for interventions aimed promoting healthy longevity.

Language: Английский

Citations

1