Abstract
Metabolic
homeostasis
is
under
strict
regulation
of
humoral
factors
across
various
taxa.
In
particular,
insulin
and
glucagon,
referred
to
in
Drosophila
as
insulin‐like
peptides
(DILPs)
adipokinetic
hormone
(AKH),
respectively,
are
key
hormones
that
regulate
metabolism
most
metazoa.
While
much
known
about
the
DILPs,
mechanisms
regulating
AKH/glucagon
production
still
poorly
understood.
this
review,
we
describe
DILPs
AKH
emphasize
need
for
future
studies
decipher
how
energy
governed
.
This
article
categorized
under:
Invertebrate
Organogenesis
>
Flies
Signaling
Pathways
Global
Mechanisms
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: May 7, 2019
Abstract
Natural
D-serine
(D-Ser)
has
been
detected
in
animals
more
than
two
decades
ago,
but
little
is
known
about
the
physiological
functions
of
D-Ser.
Here
we
reveal
sleep
regulation
by
endogenous
Sleep
was
decreased
mutants
defective
D-Ser
synthesis
or
its
receptor
N-methyl-D-aspartic
1
(NMDAR1),
increased
degradation.
not
L-Ser
rescued
phenotype
lacking
serine
racemase
(SR),
key
enzyme
for
synthesis.
Pharmacological
and
triple
gene
knockout
experiments
indicate
that
upstream
NMDAR1.
Expression
SR
both
nervous
system
intestines.
Strikingly,
reintroduction
into
specific
intestinal
epithelial
cells
sr
mutants.
Our
results
have
established
a
novel
function
surprising
role
cells.
Abstract
Metabolic
homeostasis
is
under
strict
regulation
of
humoral
factors
across
various
taxa.
In
particular,
insulin
and
glucagon,
referred
to
in
Drosophila
as
insulin‐like
peptides
(DILPs)
adipokinetic
hormone
(AKH),
respectively,
are
key
hormones
that
regulate
metabolism
most
metazoa.
While
much
known
about
the
DILPs,
mechanisms
regulating
AKH/glucagon
production
still
poorly
understood.
this
review,
we
describe
DILPs
AKH
emphasize
need
for
future
studies
decipher
how
energy
governed
.
This
article
categorized
under:
Invertebrate
Organogenesis
>
Flies
Signaling
Pathways
Global
Mechanisms
