Editorial: Horizontal Gene Transfer Mediated Bacterial Antibiotic Resistance

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 27, 2019

EDITORIAL article Front. Microbiol., 27 August 2019 | https://doi.org/10.3389/fmicb.2019.01933

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Environmental Factors Influencing Occurrence of Vibrio parahaemolyticus and Vibrio vulnificus

Applied and Environmental Microbiology, Journal Year: 2023, Volume and Issue: 89(6)

Published: May 24, 2023

The genus Vibrio includes pathogenic species that are naturally occurring in marine and estuarine environments globally. Routine monitoring for environmental parameters influencing their incidence is critical to provide a warning system the public when risk of infection high.

Language: Английский

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Phage-inducible chromosomal minimalist islands (PICMIs), a novel family of small marine satellites of virulent phages

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 22, 2024

Abstract Phage satellites are bacterial genetic elements that co-opt phage machinery for their own dissemination. Here we identify a family of satellites, named Phage-Inducible Chromosomal Minimalist Islands (PICMIs), broadly distributed in marine bacteria the Vibrionaceae. A typical PICMI is characterized by reduced gene content, does not encode genes capsid remodelling, and packages its DNA as concatemer. PICMIs integrate host genome next to fis regulator, three core proteins necessary excision replication. dependent on virulent particles spread other bacteria, protect hosts from competitive phages without interfering with helper phage. Thus, our work broadens understanding narrows down minimal number functions hijack tailed

Language: Английский

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Vibrio–bivalve interactions in health and disease

Environmental Microbiology, Journal Year: 2020, Volume and Issue: 22(10), P. 4323 - 4341

Published: May 4, 2020

Summary In the marine environment, bivalve mollusks constitute habitats for bacteria of Vibrionaceae family. Vibrios belong to microbiota healthy oysters and mussels, which have ability concentrate in their tissues body fluids, including hemolymph. Remarkably, these important aquaculture species respond differently infectious diseases. While are subject recurrent mass mortalities at different life stages, mussels appear rather resistant infections. Thus, Vibrio associated with main diseases affecting worldwide oyster production. Here, we review current knowledge on –bivalve interaction ( Crassostrea sp.) Mytilus sp.). We discuss transient versus stable associations vibrios hosts as well technical issues limiting monitoring health disease. Based oyster/mussel immunity interactions pathogenic oyster, how differences immune effectors could contribute higher resistance Finally, multiple strategies evolved by circumvent potent defences bivalves key virulence mechanisms been positively or negatively selected environment through predators.

Language: Английский

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Environmental parameters associated with incidence and transmission of pathogenic Vibrio spp .

Environmental Microbiology, Journal Year: 2021, Volume and Issue: 23(12), P. 7314 - 7340

Published: Aug. 14, 2021

Vibrio spp. thrive in warm water and moderate salinity, they are associated with aquatic invertebrates, notably crustaceans zooplankton. At least 12 known to cause infection humans, cholerae is well documented as the etiological agent of pandemic cholera. Pathogenic non-cholera spp., e.g., parahaemolyticus vulnificus, gastroenteritis, septicemia, other extra-intestinal infections. Incidence vibriosis rising globally, evidence that anthropogenic factors, primarily emissions carbon dioxide atmospheric warming more frequent intense heatwaves, significantly influence environmental parameters, temperature, nutrients, all which can enhance growth ecosystems. It not possible eliminate autochthonous environment many play a critical role nitrogen cycling. Risk prediction models provide an early warning essential for safeguarding public health. This especially important regions world vulnerable infrastructure instability, including lack 'water, sanitation, hygiene' (WASH), less resilient natural calamity, hurricanes, floods, earthquakes, and/or social disruption civil unrest, arising from war, coups, political crisis, economic recession. Incorporating environmental, social, behavioural parameters into such allows improved prediction, particularly cholera epidemics. We have reported damage WASH infrastructure, coupled elevated air temperatures followed by above average rainfall, promotes exposure population contaminated increases risk outbreak Interestingly, global predictive successful potential, modification, predict diseases caused clinically relevant In research here, focus was on incidence distribution their disease transmission. addition, molecular methods designed detection enumeration proved useful modelling described, namely context conditions favourable hence human health risk.

Language: Английский

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GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(5)

Published: May 24, 2022

Gasdermin (GSDM) is a family of pore-forming proteins that, after cleavage by caspase (CASP), induce type programmed necrotic cell death called pyroptosis. E (GSDME) the only pyroptosis-inducing member GSDM existing in teleost. To date, regulation and function teleost GSDME response to bacterial infection remain elusive. In this study, we observed activation GSDME, as well multiple CASPs, turbot Scophthalmus maximus during pathogen Vibrio harveyi. Turbot has two orthologs named SmGSDMEa SmGSDMEb. We found that was specifically cleaved CASP (SmCASP) 3/7 SmCASP6, which produced different N-terminal (NT) fragments. Only NT fragment SmCASP3/7 able Ectopically expressed activated SmGSDMEa, resulting pyroptotic death. contrast, SmCASP6 inactivated destructive domain, thus nullifying effect SmCASP3/7. Unlike SmGSDMEb SmCASP8 unable V. harveyi dramatically promoted production but not SmGSDMEb, caused pyroptosis turbot. Interference with activity significantly enhanced invasiveness lethality model. Together, these results revealed previously unrecognized bi-directional mode GSDME-mediated pyroptosis, functional difference between GSDMEa GSDMEb immune defense against infection.

Language: Английский

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Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 14, 2022

Abstract Economic losses and market constraints caused by bacterial diseases such as colibacillosis due to avian pathogenic Escherichia coli necrotic enteritis Clostridium perfringens remain major problems for poultry producers, despite substantial efforts in prevention control. Antibiotics have been used not only the treatment of diseases, but also growth promotion. Consequently, these practices linked selection spread antimicrobial resistant bacteria which constitute a significant global threat humans, animals, environment. To break down resistance (AMR), producers are restricting use (AMU) while adopting antibiotic-free (ABF) organic production satisfy consumers’ demands. However, it is well understood how ABF influence AMR profiles gut microbiome. Various Gram-negative ( Salmonella enterica serovars, Campylobacter jejuni/coli, E. ) Gram-positive Enterococcus spp. , Staphylococcus C. harboring multiple determinants reported including organically- ABF-raised chickens. In this review, we discussed systems (conventional, organic) their impacts on some potential could allow identifying issues opportunities develop efficient safe controlling pathogens.

Language: Английский

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Species-specific mechanisms of cytotoxicity toward immune cells determine the successful outcome of Vibrio infections

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(28), P. 14238 - 14247

Published: June 20, 2019

Vibrio species cause infectious diseases in humans and animals, but they can also live as commensals within their host tissues. How subverts the defenses to mount a successful infection remains poorly understood, this knowledge is critical for predicting managing disease. Here, we have investigated cellular molecular mechanisms underpinning colonization of 2 virulent an ecologically relevant model, oyster, study interactions with marine species. All strains were recognized by immune system, only nonvirulent controlled. We showed that cytotoxic hemocytes, oyster cells. By analyzing bacterial transcriptional responses infection, together gene knock-outs, discovered crassostreae tasmaniensis use distinct hemocyte lysis. Whereas V. cytotoxicity dependent on direct contact hemocytes requires ancestral encoding protein unknown function, r5.7 , phagocytosis intracellular secretion T6SS effectors. conclude proliferation commensal vibrios controlled preventing systemic infections oysters, whereas relies species-specific determinants converge compromise cell allowing evasion system.

Language: Английский

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Swine manure facilitates the spread of antibiotic resistome including tigecycline-resistant tet(X) variants to farm workers and receiving environment

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 808, P. 152157 - 152157

Published: Dec. 4, 2021

Language: Английский

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Persistent versus transient, and conventional plastic versus biodegradable plastic? —Two key questions about microplastic-water exchange of antibiotic resistance genes

Water Research, Journal Year: 2022, Volume and Issue: 222, P. 118899 - 118899

Published: July 26, 2022

Language: Английский

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