Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 25, 2025
Diagnosis
of
celiac
disease
(CeD),
an
immune-mediated
disorder,
is
based
on
clinical
presentation,
a
panel
serological
markers,
and
the
histopathological
findings
in
duodenal
biopsies.
Commonly,
pediatric
CeD
patients
fulfill
these
criteria
for
diagnosis.
However,
lack
correlation
between
serology
tests
histology,
or
no
accessible
biopsies
because
conditions
during
COVID
pandemic,
are
that
led
to
inconclusive
diagnoses.
Since
majority
carry
HLA-DQ2
and/or
DQ8
alleles,
HLA
testing
used
as
complementary
tool
diagnosis
though
costly
not
broadly
available
gastroenterology
centers.
We
performed
retrospective
study
assess
performance
when
applied
selected
groups
who
could
be
definitely
diagnosed
following
common
algorithm.
Eighty
underwent
CeD-related
alleles.
typing
contributed
34
with
positive
but
normal
mucosa
those
presented
negative
slightly
(less
than
3
times
ULN)
changes.
In
histology
serology,
did
undergo
intestinal
biopsy
(39
total),
23
cases,
only
16
were
admitted
follow-up
program.
HLA-DQ
supported
57
80
children
(71.2%)
previously
results,
providing
beneficial
approach
diagnosing
(CeD)
cases.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 234 - 234
Published: Jan. 10, 2025
Celiac
disease
(CeD)
is
a
chronic,
lifelong,
multifactorial,
polygenic,
and
autoimmune
disorder,
characteristically
triggered
by
exposure
to
the
exogenous
factor
"gluten"
in
genetically
predisposed
individuals,
with
resulting
duodenal
inflammation
enteropathy,
as
well
heterogeneous
multisystemic
extraintestinal
manifestations.
The
immunopathogenesis
of
CeD
complex,
favored
peculiar
human
leukocyte
antigen
(HLA)
genetic
predisposition,
leading
gluten
presentation
antigen-presenting
cells
CD4+
T
helper
(Th)
cells,
cell-B
cell
interactions,
production
specific
antibodies,
immune-mediated
killing
enterocytes
and,
macroscopically,
inflammation.
Here,
most
relevant
correlations
between
cellular
molecular
aspects
clinical
manifestations
this
complex
are
reviewed,
final
considerations
on
nutritional
for
management.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 377 - 377
Published: Jan. 24, 2025
Celiac
disease
is
attributable
to
a
combination
of
genetic
predisposition
and
exposure
dietary
gluten,
with
immune
system
involvement.
The
incidence
increasing
globally,
the
societal
economic
burden
celiac
stretches
beyond
cost
gluten-free
food.
This
enteropathy
that
affects
small
intestine
has
been
related
different
disorders
comorbidities.
Thus,
implications
suffering
from
this
are
multidimensional
need
further
consideration.
serious
condition
remains
under-recognized,
resulting
in
an
increased
for
programs
better
management.
review
aims
summarize
current
evidence
regarding
diseases,
special
emphasis
on
clinical
implications,
diagnosis,
management,
socioeconomical
aspects,
future
perspectives.
The Journal of Immunology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Abstract
Therapeutic
B
cell
depletion
with
monoclonal
antibodies
targeting
CD20
forced
a
rethink
about
the
pathogenic
role
of
cells
and
plasma
in
autoimmune
diseases;
however,
it
was
tempered
by
frequent
clinical
relapses
or
nonresponse
to
CD20-directed
therapy.
Here,
we
re-evaluate
strategies
autoimmunity
prompted
4
recent
advances.
The
first
is
analysis
clonal
accumulations
CD20−
CD19+
making
autoantibodies
patients
anti-CD20
refractory
disease.
second
remarkable
remissions
induced
anti-CD19
chimeric
antigen
receptor
T
cases
autoimmunity.
third
evidence
that
comprise
majority
humans,
are
not
terminally
differentiated,
long-lived,
if
self-reactive
have
potent
capacity
capture
autoantigens
via
their
surface
immunoglobulin
present
major
histocompatibility
complex
class
II–bound
peptides.
fourth
autoantigen-binding
as
key
antigen-presenting
“T
cell–mediated”
disorders,
type
1
diabetes
celiac
Viewing
human
memory
from
this
alternative
perspective
offers
an
explanation
for
why
deep
CD19
compartmental
may
be
effective
at
achieving
complete
durable
autoantibody-positive
diseases
group,
irrespective
whether
autoantibody
pathogenic.
