NADPH Oxidases: Redox Regulators of Stem Cell Fate and Function DOI Creative Commons
Tullia Maraldi, Cristina Angeloni, Cecilia Prata

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(6), P. 973 - 973

Published: June 17, 2021

One of the major sources reactive oxygen species (ROS) generated within stem cells is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family enzymes (NOXs), which are critical determinants redox state beside antioxidant defense mechanisms. This balance involved in another one that regulates cell fate: indeed, self-renewal, proliferation, and differentiation decisive steps for during embryo development, adult tissue renovation, therapy application. Ex vivo culture-expanded being investigated repair immune modulation, but events such as aging, senescence, oxidative stress reduce their ex crucial clinical applications. Here, we review role NOX-derived ROS biology functions, focusing on positive negative effects triggered by activity different NOX isoforms. We report recent findings downstream molecular targets NOX-ROS signaling can modulate homeostasis lineage commitment discuss implications expansion engraftment, function, longevity. highlights a pivotal regulator several populations, conclude these aspects have important utility cells, further studies pharmacological modulation human imperative.

Language: Английский

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut DOI Creative Commons
Alexandra Vaccaro,

Yosef Kaplan Dor,

Keishi Nambara

et al.

Cell, Journal Year: 2020, Volume and Issue: 181(6), P. 1307 - 1328.e15

Published: June 1, 2020

Language: Английский

Citations

378
The landscape of aging DOI Open Access
Yusheng Cai, Wei Song, Jiaming Li

et al.

Science China Life Sciences, Journal Year: 2022, Volume and Issue: 65(12), P. 2354 - 2454

Published: Sept. 2, 2022

Language: Английский

Citations

243
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

197
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice DOI

Kristen Browder,

Pradeep Reddy,

Mako Yamamoto

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 2(3), P. 243 - 253

Published: March 7, 2022

Language: Английский

Citations

161
Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution DOI
Tzu‐Chiao Lu, Maria Brbić, Ye-Jin Park

et al.

Science, Journal Year: 2023, Volume and Issue: 380(6650)

Published: June 15, 2023

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across organism remain unclear. Here, we present Fly Cell Atlas, single-nucleus transcriptomic map of whole aging

Language: Английский

Citations

67
Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan DOI Creative Commons
Qihang Hou,

Jingxi Huang,

Lihua Zhao

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 188, P. 106676 - 106676

Published: Jan. 21, 2023

Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Genistein is known have beneficial effects on age-related diseases, but its precise role in homeostasis of the aging gut remains be elucidated. Here, wild-type mice Zmpste24-/- progeroid were used investigate genistein lifespan mammals. A series longitudinal, clinically relevant measurements performed evaluate effect healthspan. It was found that dietary promoted a healthier longer life associated with decrease levels systemic inflammatory cytokines mice. Furthermore, ameliorated dysfunctions, such as intestinal inflammation, leaky gut, impaired epithelial regeneration. distinct genistein-mediated alteration microbiota observed by increasing Lachnospira abundance short-chain fatty acid (SCFA) production. Further fecal transplantation dirty cage sharing experiments indicated from genistein-fed rejuvenated extended demonstrated genistein-associated SCFAs alleviated tumor necrosis factor alpha-induced organoid damage. Moreover, propionate regulatory T cell-derived interleukin 10 production, which macrophage-derived inflammation. This study provided first data, authors' knowledge, indicating modulates extends healthspan existence link between provides rationale for interventions against age-associated frailty.

Language: Английский

Citations

51
Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges DOI Creative Commons
Jiahn Choi, Leonard H. Augenlicht

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(3), P. 495 - 500

Published: March 1, 2024

Abstract The intestinal epithelium is the first line of defense and acts as an interface between vast microbial world within gastrointestinal tract body’s internal milieu. not only facilitates nutrient absorption but also plays a key role in defending against pathogens regulating immune system. Central to maintaining healthy are stem cells (ISCs), which essential for replenishing throughout individual’s lifespan. Recent research has unveiled intricate interplay ISCs their niche, includes various cell types, extracellular components, signaling molecules. In this review, we delve into most recent advances ISC research, with focus on roles mucosal homeostasis how functionality influenced by niche environment. explored regulatory mechanisms that govern behavior, emphasizing dynamic adaptability face challenges. Understanding regulation impact aging environmental factors crucial advancing our knowledge developing translational approaches. Future studies should investigate interactive effects different risk function develop strategies improving regenerative capacity gut.

Language: Английский

Citations

25
Adult stem cell niches for tissue homeostasis DOI Creative Commons
Giuliana Mannino, Cristina Russo, Grazia Maugeri

et al.

Journal of Cellular Physiology, Journal Year: 2021, Volume and Issue: 237(1), P. 239 - 257

Published: Aug. 25, 2021

Abstract Adult stem cells are fundamental to maintain tissue homeostasis, growth, and regeneration. They reside in specialized environments called niches. Following activating signals, they proliferate differentiate into functional that able preserve physiology, either guarantee normal turnover or counteract damage caused by injury disease. Multiple interactions occur within the niche between cell‐intrinsic factors, supporting cells, extracellular matrix, signaling pathways. Altogether, these govern cell fate, preserving pool, regulating proliferation differentiation. Based on their response body needs, tissues can be largely classified three main categories: even conditions characterized an impressive replace rapidly exhausting (blood, epidermis, intestinal epithelium); normally require only a basal replacement, though efficiently respond increased injury, disease (skeletal muscle); equipped with less powerful niches, whose repairing ability is not overcome severe (heart nervous tissue). The purpose of this review describe characteristics niches different tissues, highlighting various components influencing activity. Although much has been done, more work needed further increase our knowledge interactions. This would important shed light chapter human physiology but also help development cell‐based strategies for clinical therapeutic applications, especially when other approaches fail.

Language: Английский

Citations

85
A stem cell aging framework, from mechanisms to interventions DOI Creative Commons
Beibei Liu, Jing Qu, Weiqi Zhang

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 41(3), P. 111451 - 111451

Published: Oct. 1, 2022

Stem cells play central roles in tissue development, homeostasis, and regeneration. Decades of scientific research have uncovered processes stem cell decline organismal aging, more recently, pioneering technologies permit the dissection its underlying mechanisms inform therapeutic development for aging aging-associated disorders. In this review, we elucidate aging-related features across different somatic types, with a specific focus on epigenetic changes, loss protein systemic influencing factors, including chronic inflammation, circadian rhythm dysregulation, metabolic disorder. Our survey summarizes biological implications, points to potential biomarkers discusses cell-based strategies promoting healthy combating age-related diseases.

Language: Английский

Citations

62
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling DOI Creative Commons
Jina Yun, Simon Hansen, Otto Morris

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 11, 2023

Abstract Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging age-related disease, SASP-related inflammation is thought to contribute tissue dysfunction diseased animals. However, whether how SASP factors influence regenerative capacity of tissues remains unclear. Here, using intestinal organoids as a model regeneration, we show that released by senescent fibroblasts deregulate stem cell activity differentiation ultimately impair crypt formation. We identify secreted N-terminal domain Ptk7 key component activates non-canonical Wnt / Ca 2+ signaling through FZD7 cells (ISCs). Changes cytosolic [Ca ] elicited promote nuclear translocation YAP induce expression YAP/TEAD target genes, impairing symmetry breaking differentiation. Our study discovers factor provides insight into mechanism which cellular contributes disease.

Language: Английский

Citations

29