Dahuang zhechong pill ameliorates hepatic fibrosis by regulating gut microbiota and metabolites

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 321, P. 117402 - 117402

Published: Nov. 13, 2023

Language: Английский

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Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids

Redox Biology, Journal Year: 2023, Volume and Issue: 64, P. 102803 - 102803

Published: June 26, 2023

Inflammatory bowel disease (IBD) is an immune-mediated gut dysfunction, which might also be associated with inflammatory phenotype in the liver. It known that nutritional intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) inversely correlated to severity and occurrence IBD. In order investigate whether n-3 PUFA can reduce liver inflammation oxidative damage due colon inflammation, we explored dextran sulfate sodium (DSS)-induced colitis model wild-type fat-1 mice endogenously increased tissue content. Besides confirming previous data alleviated DSS-induced mouse model, increase resulted a significant reduction colitis-affected as compared littermates. This was accompanied by remarkable established inflammation-dampening oxylipins, namely docosahexaenoic acid-derived 19,20-epoxydocosapentaenic acid eicosapentaenoic 15-hydroxyeicosapentaenic 17,18-epoxyeicosatetraenoic acid. Taken together, these observations demonstrate strong inverse correlation between anti-inflammatory lipidome derived from colitis-triggered changes reducing stress.

Language: Английский

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The involvement of the gut microbiota in postoperative cognitive dysfunction based on integrated metagenomic and metabolomics analysis

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(6)

Published: Nov. 21, 2023

As the population ages and medical technology advances, anesthesia procedures for elderly patients are becoming more common, leading to an increased prevalence of postoperative cognitive dysfunction. However, etiology correlation between gut microbiota dysfunction poorly understood, research in this area is limited. In study, mice with were found have reduced levels fatty acid production anti-inflammatory flora gut, Bacteroides was associated depression, depression. Furthermore, specific microbial species identified disease model, suggesting that modulation host metabolism through microbes may be a potential avenue preventing

Language: Английский

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Rhodiola rosea: a review in the context of PPPM approach

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 233 - 259

Published: May 27, 2024

Language: Английский

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Hepatic macrophage accumulation with aging: cause for concern?

AJP Gastrointestinal and Liver Physiology, Journal Year: 2021, Volume and Issue: 320(4), P. G496 - G505

Published: Jan. 20, 2021

Aging is associated with chronic, low-grade inflammation that adversely affects physiological function. The liver regulates systemic inflammation; it a source of cytokine production and also scavenges bacteria from the portal circulation to prevent infection other organs. cells primary roles in these functions, hepatic macrophages, become more numerous "normal" aging (i.e., absence disease). Here, we demonstrate evidence potential mechanisms for this phenomenon, which include augmented tumor necrosis factor-α (TNF-α) intercellular adhesion molecule-1 (ICAM-1) expression liver. Also, discuss how an age-related impairment autophagy within macrophages leads pro-oxidative state ensuing proinflammatory cytokines, particularly interleukin 6 (IL-6). Given rich posit represents major elevated IL-6 observed aging, dysfunction. Testing causal role macrophage during remains challenge, yet interventions have targeted and/or demonstrated promise treating diseases. These studies age-related, deleterious reprogramming function, worsens pathology. Therefore, accrual indeed cause concern, therapies attenuate aged phenotype will likely prove useful promoting healthy aging.

Language: Английский

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Ageing-associated phenotypes in mice

Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 214, P. 111852 - 111852

Published: July 14, 2023

Language: Английский

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Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study

Biology, Journal Year: 2023, Volume and Issue: 12(8), P. 1088 - 1088

Published: Aug. 4, 2023

Profound heat stress can damage the gastrointestinal barrier, leading to microbial translocation from gut and subsequent systemic inflammation. Despite greater vulnerability of older people wave-related morbidity mortality, it is unknown if age modulates barrier inflammation during stress. Therefore, aim this study was determine aging impacted enterocyte inflammatory responses a 3-h exposure very hot dry (47 °C, 15% humidity) with accompanying activities daily living (intermittent activity at 3 METS). Data 16 young (age 21 39 years) 65 76 humans were used address aim. In each group, log-transformed plasma concentrations intestinal fatty acid binding protein (I-FABPlog), interleukin-8 (IL-8log), tissue factor (TFlog) assessed as indices damage, inflammation, blood coagulation, respectively, before after exposure. younger cohort, I-FABPlog concentration did not increase pre post (p = 0.264, d 0.20), although elevated in group 0.014, 0.67). The magnitude participants 0.084, 0.55). Across all participants, there no correlation between change core temperature IFABPlog. There IL-8log 0.193, 0.23) following exposure, but we observed decrease 0.047, 0.48). TFlog decreased 0.071, 0.41), 0.15). Our data indicate that (an index damage) increased extreme Future studies should whether marker reflects permeability individuals

Language: Английский

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Microbiota profiling in aging-associated inflammation and liver degeneration

International Journal of Medical Microbiology, Journal Year: 2021, Volume and Issue: 311(4), P. 151500 - 151500

Published: March 29, 2021

The number of people above the age 60 years is raising world-wide being associated with an increase in prevalence aging-associated impairments and even diseases. Recent studies suggest that aging alterations bacterial endotoxin levels these changes may add to low-grade inflammation, so-called 'inflammaging', liver degeneration. However, mechanisms involved, especially, interaction intestinal microbiota barrier development inflammation degeneration have not been fully understood. aim present study was determine if composition are markers function Blood, liver, small large tissue male 2-, 15-, 24- 30-months old C57BL/6 mice fed standard chow were obtained. Intestinal composition, expression antimicrobial peptides intestine measured. Furthermore, indices damage, lipopolysaccharide binding protein (Lbp) as well toll-like receptors (Tlr) 1-9 assessed. Pairwise comparisons microbial community showed differences between 2- 24-, 15- animals while Shannon's diversity, species richness evenness indexes did differ both intestine, respectively, groups. Concentrations nitric oxide significantly lower compared 2-months mRNA defensin alpha 1 lysozyme unchanged. In contrast, tissue, older increasing fibrosis mice. Numbers inflammatory foci neutrophils livers higher These also plasma increased Lbp Tlr1, Tlr2, Tlr4, Tlr6 Tlr9 Despite no consistent robust and/or different observed, our data induction several Tlrs beginning hepatic age.

Language: Английский

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TNAP: A New Multitask Enzyme in Energy Metabolism

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10470 - 10470

Published: Sept. 28, 2021

Tissue-nonspecific alkaline phosphatase (TNAP) is mainly known for its necessary role in skeletal and dental mineralization, which relies on the hydrolysis of mineralization inhibitor inorganic pyrophosphate (PPi). Mutations gene encoding TNAP leading to severe hypophosphatasia result strongly reduced perinatal death. Fortunately, relatively recent development a recombinant with bone anchor has allowed correct defects prolong life affected babies children. Researches must however not be slowed down, because accumulating evidence indicates that activation individuals metabolic syndrome (MetS) associated enhanced cardiovascular mortality, presumably relation calcification. On other hand, appears prevent steatohepatitis mice, suggesting plays protective roles. The aim present review highlight or suspected functions energy metabolism may MetS. location liver function bile excretion, lipopolysaccharide (LPS) detoxification fatty acid transport will presented. expression adipocyte differentiation thermogenesis also discussed. Given tissue- substrate-nonspecific phosphatase, we believe it exerts several crucial pathophysiological are just beginning discovered.

Language: Английский

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Impact of age on liver damage, inflammation, and molecular signaling pathways in response to femoral fracture and hemorrhage

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Trauma causes disability and mortality globally, leading to fractures hemorrhagic shock. This can trigger an irregular inflammatory response that damages remote organs, including liver. Aging increases the susceptibility dysregulated immune responses following trauma, raising risk of organ damage, infections, higher morbidity in elderly patients. study investigates how aging affects liver inflammation damage post-trauma.24 male C57BL/6J mice were randomly divided into four groups. Twelve young (17-26 weeks) 12 aged (64-72 included. Mice further underwent either shock (trauma/hemorrhage, TH), femoral fracture (osteotomy) with external fixation (Fx) (THFx, n=6) or sham procedures (n=6). After 24 hours, sacrificed. Liver injury apoptosis evaluated using hematoxylin-eosin staining activated caspase-3 immunostaining. CXCL1 infiltrating polymorphonuclear leukocytes (PMNL) assessed by immunostaining, concentrations CXCL1, TNF, IL-1β, IL-10 tissue determined ELISA. Gene expression Tnf, Cxcl1, Il-1β, Cxcl2 was qRT-PCR. Finally, western blot used determine protein levels IκBα, Akt, their phosphorylated forms.THFx caused increased presence active caspase-3-positive cells compared corresponding group. THFx group had more severe than PMNL significantly both groups, a greater increase CXCL Pro-inflammatory TNF IL-1β elevated intensified THFx. Anti-inflammatory lower Tnf Cxcl1 gene enhanced Phosphorylation ratio IκBα versus THFx-induced phosphorylation reduced Akt group.The findings indicate may lead vulnerability trauma due responses.

Language: Английский

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